GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages

The solute carrier family is an important protein class governing compound transport across membranes. However, some of its members remain functionally unidentified. We analyzed ChIP‐seq data for the NF‐κB family transcription factor RelA and identified GLUT6 as a functionally uncharacterized transp...

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Veröffentlicht in:	FEBS letters 2019-01, Vol.593 (2), p.195-208
Hauptverfasser:	Maedera, Shotaro, Mizuno, Tadahaya, Ishiguro, Hiromu, Ito, Takuya, Soga, Tomoyoshi, Kusuhara, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Cells, Cultured Chromatin Immunoprecipitation Glucose Transport Proteins, Facilitative - genetics Glucose Transport Proteins, Facilitative - metabolism GLUT6 Glycolysis - drug effects inflammation Lipopolysaccharides - pharmacology Lysosomes - metabolism macrophages Macrophages - metabolism Macrophages, Peritoneal - cytology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Mice Mice, Knockout NF-kappa B - metabolism Signal Transduction - drug effects Transcription Factor RelA - metabolism Up-Regulation
Online-Zugang:	Volltext
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