Antimicrobial Susceptibility and Clonal Relationship of Tetracycline Resistance Genes in netF-Positive Clostridium perfringens
NetF-producing type A Clostridium perfringens , a pathotype of C. perfringens , causes necrotizing enteritis in neonatal foals and necrotizing and hemorrhagic enteritis in dogs. Recent core genome multilocus sequence typing study revealed that netF + C. perfringens strains belong to two distinct clo...
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| Veröffentlicht in: | Microbial drug resistance (Larchmont, N.Y.) N.Y.), 2019-05, Vol.25 (4), p.627-630 |
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| creator | Mehdizadeh Gohari, Iman Boerlin, Patrick Prescott, John F. |
| description | NetF-producing type A
Clostridium perfringens
, a pathotype of
C. perfringens
, causes necrotizing enteritis in neonatal foals and necrotizing and hemorrhagic enteritis in dogs. Recent core genome multilocus sequence typing study revealed that
netF
+
C. perfringens
strains belong to two distinct clonal populations (clonal complexes I and II). There are no reports on susceptibility to antimicrobial drugs of isolates from this pathotype. The susceptibility to 13 different antimicrobial drugs of 49
netF
+
strains recovered from foals or dogs with necrotizing enteritis in Canada, the United States, and Switzerland was assessed using a commercial microdilution panel designed for anaerobic human pathogens. All isolates were highly susceptible to 12 antimicrobial agents, including all beta-lactams tested, such as penicillin G and ampicillin, as well as clindamycin, chloramphenicol, and metronidazole. The isolates consistently presented a reduced susceptibility or resistance to tetracycline, which was associated with previously described tetracycline resistance genes. Clonal complex I isolates (
n
= 41) possessed the
tetA408
(P) gene, whereas clonal complex II isolates (
n
= 8) possessed the
tetA
(P)-
tetB
(P) genes and were more likely to be fully resistant. |
| doi_str_mv | 10.1089/mdr.2018.0341 |
| format | Article |
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Clostridium perfringens
, a pathotype of
C. perfringens
, causes necrotizing enteritis in neonatal foals and necrotizing and hemorrhagic enteritis in dogs. Recent core genome multilocus sequence typing study revealed that
netF
+
C. perfringens
strains belong to two distinct clonal populations (clonal complexes I and II). There are no reports on susceptibility to antimicrobial drugs of isolates from this pathotype. The susceptibility to 13 different antimicrobial drugs of 49
netF
+
strains recovered from foals or dogs with necrotizing enteritis in Canada, the United States, and Switzerland was assessed using a commercial microdilution panel designed for anaerobic human pathogens. All isolates were highly susceptible to 12 antimicrobial agents, including all beta-lactams tested, such as penicillin G and ampicillin, as well as clindamycin, chloramphenicol, and metronidazole. The isolates consistently presented a reduced susceptibility or resistance to tetracycline, which was associated with previously described tetracycline resistance genes. Clonal complex I isolates (
n
= 41) possessed the
tetA408
(P) gene, whereas clonal complex II isolates (
n
= 8) possessed the
tetA
(P)-
tetB
(P) genes and were more likely to be fully resistant.</description><identifier>ISSN: 1076-6294</identifier><identifier>EISSN: 1931-8448</identifier><identifier>DOI: 10.1089/mdr.2018.0341</identifier><identifier>PMID: 30431389</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc., publishers</publisher><subject>Ampicillin ; Antibiotics ; Antiinfectives and antibacterials ; Antimicrobial agents ; Bacteria ; Chloramphenicol ; Chloromycetin ; Clindamycin ; Clostridium perfringens ; Dogs ; Genes ; Genomes ; Hemorrhage ; Hemorrhagic enteritis ; Metronidazole ; Multilocus sequence typing ; Necrotizing enterocolitis ; Neonates ; Nucleotide sequence ; Penicillin ; Veterinary Medicine ; β-Lactam antibiotics</subject><ispartof>Microbial drug resistance (Larchmont, N.Y.), 2019-05, Vol.25 (4), p.627-630</ispartof><rights>2019, Mary Ann Liebert, Inc., publishers</rights><rights>Copyright Mary Ann Liebert, Inc. May 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-4043f6e5dd335e3b33229ea1a94eb42fe3fb59c02b4fa8098ad6f96629d0546c3</citedby><cites>FETCH-LOGICAL-c365t-4043f6e5dd335e3b33229ea1a94eb42fe3fb59c02b4fa8098ad6f96629d0546c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30431389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mehdizadeh Gohari, Iman</creatorcontrib><creatorcontrib>Boerlin, Patrick</creatorcontrib><creatorcontrib>Prescott, John F.</creatorcontrib><title>Antimicrobial Susceptibility and Clonal Relationship of Tetracycline Resistance Genes in netF-Positive Clostridium perfringens</title><title>Microbial drug resistance (Larchmont, N.Y.)</title><addtitle>Microb Drug Resist</addtitle><description>NetF-producing type A
Clostridium perfringens
, a pathotype of
C. perfringens
, causes necrotizing enteritis in neonatal foals and necrotizing and hemorrhagic enteritis in dogs. Recent core genome multilocus sequence typing study revealed that
netF
+
C. perfringens
strains belong to two distinct clonal populations (clonal complexes I and II). There are no reports on susceptibility to antimicrobial drugs of isolates from this pathotype. The susceptibility to 13 different antimicrobial drugs of 49
netF
+
strains recovered from foals or dogs with necrotizing enteritis in Canada, the United States, and Switzerland was assessed using a commercial microdilution panel designed for anaerobic human pathogens. All isolates were highly susceptible to 12 antimicrobial agents, including all beta-lactams tested, such as penicillin G and ampicillin, as well as clindamycin, chloramphenicol, and metronidazole. The isolates consistently presented a reduced susceptibility or resistance to tetracycline, which was associated with previously described tetracycline resistance genes. Clonal complex I isolates (
n
= 41) possessed the
tetA408
(P) gene, whereas clonal complex II isolates (
n
= 8) possessed the
tetA
(P)-
tetB
(P) genes and were more likely to be fully resistant.</description><subject>Ampicillin</subject><subject>Antibiotics</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial agents</subject><subject>Bacteria</subject><subject>Chloramphenicol</subject><subject>Chloromycetin</subject><subject>Clindamycin</subject><subject>Clostridium perfringens</subject><subject>Dogs</subject><subject>Genes</subject><subject>Genomes</subject><subject>Hemorrhage</subject><subject>Hemorrhagic enteritis</subject><subject>Metronidazole</subject><subject>Multilocus sequence typing</subject><subject>Necrotizing enterocolitis</subject><subject>Neonates</subject><subject>Nucleotide sequence</subject><subject>Penicillin</subject><subject>Veterinary Medicine</subject><subject>β-Lactam antibiotics</subject><issn>1076-6294</issn><issn>1931-8448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkTFv1TAURi1ERUthZEWRWFjyavs6xh6rp7YgVaIqZY6c5BpulTjBdpDewm_H0SsMLEy2fI8--X6HsTeC7wQ39mIa4k5yYXYclHjGzoQFURulzPNy5x90raVVp-xlSo-c80ZoeMFOgSsQYOwZ-3UZMk3Ux7kjN1Zf1tTjkqmjkfKhcmGo9uMcyuQeR5dpDuk7LdXsqwfM0fWHfqSAZZgoZRd6rG4wYKooVAHzdX03J8r0E7eUlCMNtE7VgtFHCt8wpFfsxLsx4eun85x9vb562H-sbz_ffNpf3tY96CbXqvzXa2yGAaBB6ACktOiEswo7JT2C7xrbc9kp7wy3xg3aW11WH3ijdA_n7P0xd4nzjxVTbicqm46jCzivqZUCwEhteVPQd_-gj_MaSwWFkiAMyFJuoeojVZpLKaJvl0iTi4dW8HYT0xYx7Sam3cQU_u1T6tpNOPyl_5goAByB7dmFMBJ2GPN_Yn8D63CcPw</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Mehdizadeh Gohari, Iman</creator><creator>Boerlin, Patrick</creator><creator>Prescott, John F.</creator><general>Mary Ann Liebert, Inc., publishers</general><general>Mary Ann Liebert, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20190501</creationdate><title>Antimicrobial Susceptibility and Clonal Relationship of Tetracycline Resistance Genes in netF-Positive Clostridium perfringens</title><author>Mehdizadeh Gohari, Iman ; Boerlin, Patrick ; Prescott, John F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-4043f6e5dd335e3b33229ea1a94eb42fe3fb59c02b4fa8098ad6f96629d0546c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Ampicillin</topic><topic>Antibiotics</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial agents</topic><topic>Bacteria</topic><topic>Chloramphenicol</topic><topic>Chloromycetin</topic><topic>Clindamycin</topic><topic>Clostridium perfringens</topic><topic>Dogs</topic><topic>Genes</topic><topic>Genomes</topic><topic>Hemorrhage</topic><topic>Hemorrhagic enteritis</topic><topic>Metronidazole</topic><topic>Multilocus sequence typing</topic><topic>Necrotizing enterocolitis</topic><topic>Neonates</topic><topic>Nucleotide sequence</topic><topic>Penicillin</topic><topic>Veterinary Medicine</topic><topic>β-Lactam antibiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mehdizadeh Gohari, Iman</creatorcontrib><creatorcontrib>Boerlin, Patrick</creatorcontrib><creatorcontrib>Prescott, John F.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Microbial drug resistance (Larchmont, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mehdizadeh Gohari, Iman</au><au>Boerlin, Patrick</au><au>Prescott, John F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial Susceptibility and Clonal Relationship of Tetracycline Resistance Genes in netF-Positive Clostridium perfringens</atitle><jtitle>Microbial drug resistance (Larchmont, N.Y.)</jtitle><addtitle>Microb Drug Resist</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>25</volume><issue>4</issue><spage>627</spage><epage>630</epage><pages>627-630</pages><issn>1076-6294</issn><eissn>1931-8448</eissn><abstract>NetF-producing type A
Clostridium perfringens
, a pathotype of
C. perfringens
, causes necrotizing enteritis in neonatal foals and necrotizing and hemorrhagic enteritis in dogs. Recent core genome multilocus sequence typing study revealed that
netF
+
C. perfringens
strains belong to two distinct clonal populations (clonal complexes I and II). There are no reports on susceptibility to antimicrobial drugs of isolates from this pathotype. The susceptibility to 13 different antimicrobial drugs of 49
netF
+
strains recovered from foals or dogs with necrotizing enteritis in Canada, the United States, and Switzerland was assessed using a commercial microdilution panel designed for anaerobic human pathogens. All isolates were highly susceptible to 12 antimicrobial agents, including all beta-lactams tested, such as penicillin G and ampicillin, as well as clindamycin, chloramphenicol, and metronidazole. The isolates consistently presented a reduced susceptibility or resistance to tetracycline, which was associated with previously described tetracycline resistance genes. Clonal complex I isolates (
n
= 41) possessed the
tetA408
(P) gene, whereas clonal complex II isolates (
n
= 8) possessed the
tetA
(P)-
tetB
(P) genes and were more likely to be fully resistant.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc., publishers</pub><pmid>30431389</pmid><doi>10.1089/mdr.2018.0341</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1076-6294 |
| ispartof | Microbial drug resistance (Larchmont, N.Y.), 2019-05, Vol.25 (4), p.627-630 |
| issn | 1076-6294 1931-8448 |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Ampicillin Antibiotics Antiinfectives and antibacterials Antimicrobial agents Bacteria Chloramphenicol Chloromycetin Clindamycin Clostridium perfringens Dogs Genes Genomes Hemorrhage Hemorrhagic enteritis Metronidazole Multilocus sequence typing Necrotizing enterocolitis Neonates Nucleotide sequence Penicillin Veterinary Medicine β-Lactam antibiotics |
| title | Antimicrobial Susceptibility and Clonal Relationship of Tetracycline Resistance Genes in netF-Positive Clostridium perfringens |
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