Clinicopathological and genomic comparisons between different histologic components in combined small cell lung cancer and non-small cell lung cancer

•Adenocarcinoma can transform into SCLC as a mechanism of resistance to TKIs.•We investigated genetic profiles of combined SCLC/NSCLC patients.•SCLC and NSCLC components showed a high consistency in EGFR/TP53/RB1 mutations.•TP53/RB1 inactivation may be an early event in the tumorigenesis of combined...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2018-11, Vol.125, p.282-290
Hauptverfasser:	Lin, Mong-Wei, Su, Kang-Yi, Su, Te-Jen, Chang, Chia-Ching, Lin, Jing-Wei, Lee, Yi-Hsuan, Yu, Sung-Liang, Chen, Jin-Shing, Hsieh, Min-Shu
Format:	Artikel
Sprache:	eng
Schlagworte:	Lung adenocarcinoma Mutation analysis Next-generation sequencing Small cell lung cancer Small cell transformation
Online-Zugang:	Volltext
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