Breast cancer risk associated with BRCA1/2 variants in the Pakistani population

Background Majority of the BRCA1 and BRCA2 mutations are associated with the risk of sporadic and familial breast cancer. Since these genes are significant in DNA repair mechanisms, we focused homology-directed DNA repair (HDDR) and BRCA complex. Methods We selected BRCA1 variant (rs80356932, 4491C/...

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Veröffentlicht in:	Breast cancer (Tokyo, Japan) Japan), 2019-05, Vol.26 (3), p.365-372
Hauptverfasser:	Abbas, Saba, Siddique, Ayesha, Shahid, Naeem, Khan, Rabbia Tariq, Fatima, Warda
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged BRCA1 Protein - genetics BRCA2 Protein - genetics BRCA2 Protein - metabolism Breast cancer Breast Neoplasms - genetics Cancer Cancer Research DNA repair Fanconi Anemia Complementation Group N Protein - metabolism Female Gene mutations Genetic aspects Genetic Association Studies Genetic Predisposition to Disease - genetics Genotype Health aspects Humans Medicine Medicine & Public Health Middle Aged Molecular Docking Simulation Mutation Oncology Oncology, Experimental Original Article Pakistan Polymorphism, Single Nucleotide Risk factors Surgery Surgical Oncology Tryptophan
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