Phosphorescent cationic iridium(iii) complexes dynamically bound to cyclodextrin vesicles: applications in live cell imaging
We report cationic Ir(iii) complexes functionalized with adamantyl groups designed to bind to β-cyclodextrin vesicles (CDV) with high affinity ( = 1 × 10 M ). The emission of the complexes is tuned by changing the nature of the cyclometalating ligands. The host-guest adduct of CDV and Ir(iii) comple...
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| Veröffentlicht in: | Chemical science (Cambridge) 2018-10, Vol.9 (40), p.7822-7828 |
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| creator | Schibilla, Frauke Holthenrich, Anna Song, Boyi Linard Matos, Anna Lívia Grill, David Rota Martir, Diego Gerke, Volker Zysman-Colman, Eli Ravoo, Bart Jan |
| description | We report cationic Ir(iii) complexes functionalized with adamantyl groups designed to bind to β-cyclodextrin vesicles (CDV) with high affinity (
= 1 × 10
M
). The emission of the complexes is tuned by changing the nature of the cyclometalating ligands. The host-guest adduct of CDV and Ir(iii) complexes shows increased and significantly blue-shifted emission due to the lower mobility of the Ir(iii)-complexes residing in the less polar environment of the vesicle surface. Ir(iii)-decorated CDV are efficiently taken up by cells and can be used in live cell imaging. The CDV act as carriers to transport the phosphorescent complexes into cells where they selectively stain mitochondria. |
| doi_str_mv | 10.1039/c8sc02875c |
| format | Article |
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= 1 × 10
M
). The emission of the complexes is tuned by changing the nature of the cyclometalating ligands. The host-guest adduct of CDV and Ir(iii) complexes shows increased and significantly blue-shifted emission due to the lower mobility of the Ir(iii)-complexes residing in the less polar environment of the vesicle surface. Ir(iii)-decorated CDV are efficiently taken up by cells and can be used in live cell imaging. The CDV act as carriers to transport the phosphorescent complexes into cells where they selectively stain mitochondria.</description><identifier>ISSN: 2041-6520</identifier><identifier>EISSN: 2041-6539</identifier><identifier>DOI: 10.1039/c8sc02875c</identifier><identifier>PMID: 30429991</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Cations ; Cyclodextrins ; Emission spectra ; Iridium ; Iridium compounds ; Mitochondria ; Phosphorescence ; Polar environments ; Titration calorimetry ; Vesicles</subject><ispartof>Chemical science (Cambridge), 2018-10, Vol.9 (40), p.7822-7828</ispartof><rights>Copyright Royal Society of Chemistry 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-4e30243e712834d2f6c859408538c51694f393a11f26f0585b594ad58f586c923</citedby><cites>FETCH-LOGICAL-c417t-4e30243e712834d2f6c859408538c51694f393a11f26f0585b594ad58f586c923</cites><orcidid>0000-0003-2202-7485 ; 0000-0001-7183-6022</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30429991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schibilla, Frauke</creatorcontrib><creatorcontrib>Holthenrich, Anna</creatorcontrib><creatorcontrib>Song, Boyi</creatorcontrib><creatorcontrib>Linard Matos, Anna Lívia</creatorcontrib><creatorcontrib>Grill, David</creatorcontrib><creatorcontrib>Rota Martir, Diego</creatorcontrib><creatorcontrib>Gerke, Volker</creatorcontrib><creatorcontrib>Zysman-Colman, Eli</creatorcontrib><creatorcontrib>Ravoo, Bart Jan</creatorcontrib><title>Phosphorescent cationic iridium(iii) complexes dynamically bound to cyclodextrin vesicles: applications in live cell imaging</title><title>Chemical science (Cambridge)</title><addtitle>Chem Sci</addtitle><description>We report cationic Ir(iii) complexes functionalized with adamantyl groups designed to bind to β-cyclodextrin vesicles (CDV) with high affinity (
= 1 × 10
M
). The emission of the complexes is tuned by changing the nature of the cyclometalating ligands. The host-guest adduct of CDV and Ir(iii) complexes shows increased and significantly blue-shifted emission due to the lower mobility of the Ir(iii)-complexes residing in the less polar environment of the vesicle surface. Ir(iii)-decorated CDV are efficiently taken up by cells and can be used in live cell imaging. The CDV act as carriers to transport the phosphorescent complexes into cells where they selectively stain mitochondria.</description><subject>Cations</subject><subject>Cyclodextrins</subject><subject>Emission spectra</subject><subject>Iridium</subject><subject>Iridium compounds</subject><subject>Mitochondria</subject><subject>Phosphorescence</subject><subject>Polar environments</subject><subject>Titration calorimetry</subject><subject>Vesicles</subject><issn>2041-6520</issn><issn>2041-6539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkV9LHTEQxUOpVFFf-gEk0BcVrk0yyW7SN1nqHxBaaPu85M5mNZLdbJNd8YIfvrFXfXBeZuD8OJzhEPKZszPOwHxFnZEJXSv8QPYEk3xVKTAf327BdslhzvesDABXov5EdoFJYYzhe-Tp513M011MLqMbZ4p29nH0SH3ynV-GY-_9CcU4TME9uky7zWgHjzaEDV3HZezoHCluMMTOPc7Jj_TBZY_B5W_UTlPwW8NMixL8g6PoQqB-sLd-vD0gO70N2R2-7H3y5-L77-ZqdfPj8ro5v1mh5PW8kg6YkOBqLjTITvQVamUk0wo0Kl4Z2YMBy3kvqp4prdZFtZ3SvdIVGgH75HjrO6X4d3F5bgefn4PY0cUlt4IDaAE1yIJ-eYfexyWNJV2hBGdSsloV6nRLYYo5J9e3Uyo_pU3LWftcS9voX83_WpoCH71YLuvBdW_oawnwDwy3h8E</recordid><startdate>20181028</startdate><enddate>20181028</enddate><creator>Schibilla, Frauke</creator><creator>Holthenrich, Anna</creator><creator>Song, Boyi</creator><creator>Linard Matos, Anna Lívia</creator><creator>Grill, David</creator><creator>Rota Martir, Diego</creator><creator>Gerke, Volker</creator><creator>Zysman-Colman, Eli</creator><creator>Ravoo, Bart Jan</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2202-7485</orcidid><orcidid>https://orcid.org/0000-0001-7183-6022</orcidid></search><sort><creationdate>20181028</creationdate><title>Phosphorescent cationic iridium(iii) complexes dynamically bound to cyclodextrin vesicles: applications in live cell imaging</title><author>Schibilla, Frauke ; Holthenrich, Anna ; Song, Boyi ; Linard Matos, Anna Lívia ; Grill, David ; Rota Martir, Diego ; Gerke, Volker ; Zysman-Colman, Eli ; Ravoo, Bart Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-4e30243e712834d2f6c859408538c51694f393a11f26f0585b594ad58f586c923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cations</topic><topic>Cyclodextrins</topic><topic>Emission spectra</topic><topic>Iridium</topic><topic>Iridium compounds</topic><topic>Mitochondria</topic><topic>Phosphorescence</topic><topic>Polar environments</topic><topic>Titration calorimetry</topic><topic>Vesicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schibilla, Frauke</creatorcontrib><creatorcontrib>Holthenrich, Anna</creatorcontrib><creatorcontrib>Song, Boyi</creatorcontrib><creatorcontrib>Linard Matos, Anna Lívia</creatorcontrib><creatorcontrib>Grill, David</creatorcontrib><creatorcontrib>Rota Martir, Diego</creatorcontrib><creatorcontrib>Gerke, Volker</creatorcontrib><creatorcontrib>Zysman-Colman, Eli</creatorcontrib><creatorcontrib>Ravoo, Bart Jan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical science (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schibilla, Frauke</au><au>Holthenrich, Anna</au><au>Song, Boyi</au><au>Linard Matos, Anna Lívia</au><au>Grill, David</au><au>Rota Martir, Diego</au><au>Gerke, Volker</au><au>Zysman-Colman, Eli</au><au>Ravoo, Bart Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phosphorescent cationic iridium(iii) complexes dynamically bound to cyclodextrin vesicles: applications in live cell imaging</atitle><jtitle>Chemical science (Cambridge)</jtitle><addtitle>Chem Sci</addtitle><date>2018-10-28</date><risdate>2018</risdate><volume>9</volume><issue>40</issue><spage>7822</spage><epage>7828</epage><pages>7822-7828</pages><issn>2041-6520</issn><eissn>2041-6539</eissn><abstract>We report cationic Ir(iii) complexes functionalized with adamantyl groups designed to bind to β-cyclodextrin vesicles (CDV) with high affinity (
= 1 × 10
M
). The emission of the complexes is tuned by changing the nature of the cyclometalating ligands. The host-guest adduct of CDV and Ir(iii) complexes shows increased and significantly blue-shifted emission due to the lower mobility of the Ir(iii)-complexes residing in the less polar environment of the vesicle surface. Ir(iii)-decorated CDV are efficiently taken up by cells and can be used in live cell imaging. The CDV act as carriers to transport the phosphorescent complexes into cells where they selectively stain mitochondria.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>30429991</pmid><doi>10.1039/c8sc02875c</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2202-7485</orcidid><orcidid>https://orcid.org/0000-0001-7183-6022</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical science (Cambridge), 2018-10, Vol.9 (40), p.7822-7828 |
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| language | eng |
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| source | DOAJ; PubMed Central Open Access; Free E-Journal (出版社公開部分のみ）; PubMed Central |
| subjects | Cations Cyclodextrins Emission spectra Iridium Iridium compounds Mitochondria Phosphorescence Polar environments Titration calorimetry Vesicles |
| title | Phosphorescent cationic iridium(iii) complexes dynamically bound to cyclodextrin vesicles: applications in live cell imaging |
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