Protective effects of ginsenoside Rg3 on TNF-α-induced human nucleus pulposus cells through inhibiting NF-κB signaling pathway

This work aims to evaluate the effect of ginsenoside Rg3 on the apoptosis, proliferation, extracellular matrix (ECM) metabolism and oxidative stress-induced damage of human nucleus pulposus cells (NPCs) induced by TNF-α. The human NPCs were divided into Control, TNF-α, TNF-α + low Rg3, TNF-α + mediu...

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Veröffentlicht in:	Life sciences (1973) 2019-01, Vol.216, p.1-9
Hauptverfasser:	Chen, Jiang, Liu, Gen-Zhe, Sun, Qi, Zhang, Fan, Liu, Chu-yin, Yuan, Lin, Zhao, Xue-Qian, Wang, Yong-Jun, Jia, Yu-Song
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggrecan Annexin V Apoptosis BAX protein Bcl-2 protein Caspase Caspase-3 Cell cycle Cholecystokinin Control Enzyme-linked immunosorbent assay Extracellular matrix Flow cytometry Gene expression Genes Ginsenosides Glutathione Glutathione peroxidase Intervertebral discs Malondialdehyde Metabolism NF-κB NF-κB protein Nuclei (cytology) Nucleus pulposus Nucleus pulposus cells Oxidative metabolism Oxidative stress Peroxidase Proteins Reactive oxygen species Rg3 Signal transduction Signaling Superoxide dismutase TNF-α Western blotting
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