Sensing α‐Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration

Parkinson's disease and other synucleinopathies are characterized by the accumulation of aggregated α‐synuclein in intracellular proteinaceous inclusions. The progressive nature of synucleinopathies seems to be related to the cell‐to‐cell spreading of α‐synuclein pathology, and several possible...

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Veröffentlicht in:	Movement disorders 2018-11, Vol.33 (11), p.1675-1684
Hauptverfasser:	Brás, Inês Caldeira, Lopes, Luísa V., Outeiro, Tiago Fleming
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cell spreading Cofilin Cognitive ability Fyn protein Glutamatergic transmission Membrane proteins Movement disorders Neurodegeneration Neurodegenerative diseases Parkinson's disease Phosphorylation Potentiation prion Prion protein Proteins receptor Rods spreading Synapses Synuclein synucleinopathy α‐synuclein
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