Novel sintering-free scaffolds obtained by additive manufacturing for concurrent bone regeneration and drug delivery: Proof of concept

Advances on the fabrication of sintering-free biphasic calcium phosphate (BCP)/natural polymer composite scaffolds using robocasting as additive manufacturing technique are presented in the present work. Inks with high amounts of BCP powders (45 vol%) containing different HA/β-TCP ratios, in presenc...

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Veröffentlicht in:	Materials Science & Engineering C 2019-01, Vol.94, p.426-436
Hauptverfasser:	Marques, Catarina F., Olhero, Susana M., Torres, Paula M.C., Abrantes, João C.C., Fateixa, Sara, Nogueira, Helena I.S., Ribeiro, Isabel A.C., Bettencourt, Ana, Sousa, Aureliana, Granja, Pedro L., Ferreira, José M.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Additive manufacturing Antibiotics Bacteria Biomedical materials Bone growth Bone regeneration Bone Regeneration - drug effects Bone Regeneration - physiology Calcium Calcium phosphates Cell Count Cell Death - drug effects Chitosan Composite materials Composite scaffolds Crosslinking Drug delivery Drug Delivery Systems Drug Liberation Elastic Modulus Extrudability Extrusion Fabrication Fibroblasts - cytology Fibroblasts - drug effects Humans Hydroxyapatite Imaging, Three-Dimensional Infant, Newborn Inks Levofloxacin Levofloxacin - pharmacology Local-drug-delivery Manufacturing Materials science Mechanical properties Microbial Sensitivity Tests Microstructure Polymer matrix composites Polymers Powders Regeneration Regeneration (physiology) Rheological properties Robocasting Scaffolds Sintering Sintering (powder metallurgy) Sintering-free biphasic CaP Spectrum Analysis, Raman Staphylococcus aureus - drug effects Strong interactions (field theory) Studies Substitute bone Surgical implants Temperature Tissue Scaffolds - chemistry Viscosity
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