Mapping the MHC Class I-Spliced Immunopeptidome of Cancer Cells

Anticancer immunotherapies demand optimal epitope targets, which could include proteasome-generated spliced peptides if tumor cells were to present them. Here, we show that spliced peptides are widely presented by MHC class I molecules of colon and breast carcinoma cell lines. The peptides derive fr...

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Veröffentlicht in:	Cancer immunology research 2019-01, Vol.7 (1), p.62-76
Hauptverfasser:	Liepe, Juliane, Sidney, John, Lorenz, Felix K M, Sette, Alessandro, Mishto, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - immunology Base Sequence Breast Neoplasms - genetics Breast Neoplasms - immunology Cell Line, Tumor Colonic Neoplasms - genetics Colonic Neoplasms - immunology Genes, MHC Class I Humans Peptides - genetics Peptides - immunology Protein Splicing
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