Advances in behavioral animal models of alcohol use disorder
Alcohol use disorder (AUD) is a multifaceted neuropsychiatric disease that combines behavioral, psychosocial, and neurobiological aspects. Over the previous decade, animal models have advanced in modeling the major psychological constructs that characterize AUD. These advances pave the road for more...
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| Veröffentlicht in: | Alcohol (Fayetteville, N.Y.) N.Y.), 2019-02, Vol.74, p.73-82 |
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| creator | Goltseker, Koral Hopf, Frederic W. Barak, Segev |
| description | Alcohol use disorder (AUD) is a multifaceted neuropsychiatric disease that combines behavioral, psychosocial, and neurobiological aspects. Over the previous decade, animal models have advanced in modeling the major psychological constructs that characterize AUD. These advances pave the road for more sophisticated behavioral models that capture addiction-related aspects, such as alcohol craving, compulsive seeking and intake, dependence, and relapse. In this review, we survey the recent progress in behavioral animal modeling of five aspects of AUD: alcohol consumption, dependence, and seeking; compulsivity in alcohol intake despite adverse outcomes; vulnerability and resilience factors in alcohol addiction; relapse despite treatment; and relapse prevention by manipulating alcohol-associated memory reconsolidation. These advances represent a general attempt to grasp the complexity and multidimensional nature of AUD, and to focus on behavioral characteristics that better reflect and model this disorder.
•Modeling the complexity of alcohol use disorder requires compilation of different behavioral animal models.•New procedures of alcohol consumption and seeking model voluntary dependence and persistent craving and seeking.•Procedures of compulsive-like alcohol-related behaviors provide an important characteristic of alcohol addiction.•Individual differences in vulnerability and resilience to alcohol addiction should be better characterized.•Modeling alcohol relapse and its prevention opens a critical translational window for treatment development. |
| doi_str_mv | 10.1016/j.alcohol.2018.05.014 |
| format | Article |
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•Modeling the complexity of alcohol use disorder requires compilation of different behavioral animal models.•New procedures of alcohol consumption and seeking model voluntary dependence and persistent craving and seeking.•Procedures of compulsive-like alcohol-related behaviors provide an important characteristic of alcohol addiction.•Individual differences in vulnerability and resilience to alcohol addiction should be better characterized.•Modeling alcohol relapse and its prevention opens a critical translational window for treatment development.</description><subject>Addiction</subject><subject>Addictions</subject><subject>Addictive behaviors</subject><subject>Alcohol</subject><subject>Alcohol Drinking</subject><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Alcoholism</subject><subject>Alcoholism - psychology</subject><subject>Alcohols</subject><subject>Animal models</subject><subject>Animals</subject><subject>Behavior</subject><subject>Compulsive Behavior</subject><subject>Compulsivity</subject><subject>Dependence</subject><subject>Disease Models, Animal</subject><subject>Drug addiction</subject><subject>Humans</subject><subject>Individual differences</subject><subject>Learning</subject><subject>Memory</subject><subject>Mental disorders</subject><subject>Phenotype</subject><subject>Physiology</subject><subject>Recurrence</subject><subject>Relapse</subject><subject>Rodents</subject><issn>0741-8329</issn><issn>1873-6823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkMFq3DAQhkVoSTZpH6HF0EsvdkcaSbagUEJo00Kgl-QsZGlMtHitVFov9O2jsNseeulpLt8_M__H2DsOHQeuP207N_v0mOZOAB86UB1wecY2fOix1YPAV2wDveTtgMJcsMtStgDQ9705ZxcIUkjTmw37fB0ObvFUmrg0Iz26Q0zZzY1b4q6OXQo0lyZNzelasxZqQiwpB8pv2OvJzYXenuYVe_j29f7me3v38_bHzfVd69HgvlVSO4GESvVekhq0Md6FURrjNGqaegnOgxoNoJgcB4SgFU1mGAcAPiq8Yh-Pe59y-rVS2dtdLJ7m2S2U1mIFR5TIUUNFP_yDbtOal_pdpbQwg5YoKqWOlM-plEyTfcq1b_5tOdgXvXZrT4Xti14Lyla9Nff-tH0ddxT-pv74rMCXI1Ct0SFStsVHqn5DzOT3NqT4nxPPC9qL9g</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Goltseker, Koral</creator><creator>Hopf, Frederic W.</creator><creator>Barak, Segev</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QG</scope><scope>7RV</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AM</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGRYB</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K7.</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0O</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201902</creationdate><title>Advances in behavioral animal models of alcohol use disorder</title><author>Goltseker, Koral ; Hopf, Frederic W. ; Barak, Segev</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-546a23e3557c4e58699cadb499a636ef740ac05b9032fa1030d65ef98b8001b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Addiction</topic><topic>Addictions</topic><topic>Addictive behaviors</topic><topic>Alcohol</topic><topic>Alcohol Drinking</topic><topic>Alcohol use</topic><topic>Alcoholic beverages</topic><topic>Alcoholism</topic><topic>Alcoholism - psychology</topic><topic>Alcohols</topic><topic>Animal models</topic><topic>Animals</topic><topic>Behavior</topic><topic>Compulsive Behavior</topic><topic>Compulsivity</topic><topic>Dependence</topic><topic>Disease Models, Animal</topic><topic>Drug addiction</topic><topic>Humans</topic><topic>Individual differences</topic><topic>Learning</topic><topic>Memory</topic><topic>Mental disorders</topic><topic>Phenotype</topic><topic>Physiology</topic><topic>Recurrence</topic><topic>Relapse</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goltseker, Koral</creatorcontrib><creatorcontrib>Hopf, Frederic W.</creatorcontrib><creatorcontrib>Barak, Segev</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Criminal Justice Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Criminology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Criminal Justice Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goltseker, Koral</au><au>Hopf, Frederic W.</au><au>Barak, Segev</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advances in behavioral animal models of alcohol use disorder</atitle><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle><addtitle>Alcohol</addtitle><date>2019-02</date><risdate>2019</risdate><volume>74</volume><spage>73</spage><epage>82</epage><pages>73-82</pages><issn>0741-8329</issn><eissn>1873-6823</eissn><abstract>Alcohol use disorder (AUD) is a multifaceted neuropsychiatric disease that combines behavioral, psychosocial, and neurobiological aspects. Over the previous decade, animal models have advanced in modeling the major psychological constructs that characterize AUD. These advances pave the road for more sophisticated behavioral models that capture addiction-related aspects, such as alcohol craving, compulsive seeking and intake, dependence, and relapse. In this review, we survey the recent progress in behavioral animal modeling of five aspects of AUD: alcohol consumption, dependence, and seeking; compulsivity in alcohol intake despite adverse outcomes; vulnerability and resilience factors in alcohol addiction; relapse despite treatment; and relapse prevention by manipulating alcohol-associated memory reconsolidation. These advances represent a general attempt to grasp the complexity and multidimensional nature of AUD, and to focus on behavioral characteristics that better reflect and model this disorder.
•Modeling the complexity of alcohol use disorder requires compilation of different behavioral animal models.•New procedures of alcohol consumption and seeking model voluntary dependence and persistent craving and seeking.•Procedures of compulsive-like alcohol-related behaviors provide an important characteristic of alcohol addiction.•Individual differences in vulnerability and resilience to alcohol addiction should be better characterized.•Modeling alcohol relapse and its prevention opens a critical translational window for treatment development.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30424979</pmid><doi>10.1016/j.alcohol.2018.05.014</doi><tpages>10</tpages></addata></record> |
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| subjects | Addiction Addictions Addictive behaviors Alcohol Alcohol Drinking Alcohol use Alcoholic beverages Alcoholism Alcoholism - psychology Alcohols Animal models Animals Behavior Compulsive Behavior Compulsivity Dependence Disease Models, Animal Drug addiction Humans Individual differences Learning Memory Mental disorders Phenotype Physiology Recurrence Relapse Rodents |
| title | Advances in behavioral animal models of alcohol use disorder |
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