Extrapulmonary translocation of intratracheally instilled fine and ultrafine particles via direct and alveolar macrophage-associated routes

Translocation of inhaled ultrafine particles from the lungs into the blood may impair cardiovascular function. We administered ultrafine (20-nm) and fine (200-nm) gold colloid or fluorescein-labeled polystyrene particles to mice intratracheally and examined their localization in the lung and extrapu...

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Veröffentlicht in:	Archives of toxicology 2009-05, Vol.83 (5), p.429-437
Hauptverfasser:	Furuyama, Akiko, Kanno, Sanae, Kobayashi, Takahiro, Hirano, Seishiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Bronchoalveolar Lavage Fluid - cytology Cardiovascular disease Chromosome aberrations Environmental Health Epidemiology Gold Colloid - analysis Gold Colloid - metabolism Inhalation Exposure Inorganic Compounds Kidney - metabolism Liver - metabolism Lung - metabolism Lung - ultrastructure Lungs Macrophages, Alveolar - metabolism Macrophages, Alveolar - ultrastructure Male Medical genetics Medical sciences Mice Mice, Inbred BALB C Myocardium - metabolism Occupational Medicine/Industrial Medicine Particle Size Particulate Matter - metabolism Pharmacology/Toxicology Respiratory diseases Rodents Spleen - metabolism Time Factors Tissue Distribution Toxicology
Online-Zugang:	Volltext
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