HSPB8 over‐expression prevents disruption of blood–brain barrier by promoting autophagic flux after cerebral ischemia/reperfusion injury

Heat‐shock protein B8 (HSPB8) has been recently reported to confer neuroprotection against ischemia/reperfusion (I/R)‐induced cerebral injury in vivo and in vitro. However, the molecular mechanism is still elusive. This study focused on the effect of intracerebroventricular (i.c.v) delivery of lenti...

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Veröffentlicht in:	Journal of neurochemistry 2019-01, Vol.148 (1), p.97-113
Hauptverfasser:	Li, Fazhao, Yang, Binbin, Li, Ting, Gong, Xiyu, Zhou, Fangfang, Hu, Zhiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Autophagy - physiology Blood Blood-brain barrier Blood-Brain Barrier - metabolism Brain Brain Edema - etiology Brain Edema - metabolism Brain Ischemia - etiology Brain Ischemia - metabolism Cerebral blood flow cerebral ischemia/reperfusion Chemical compounds Degradation Disruption Edema Extravasation heat shock protein B8 Heat shock proteins Heat-Shock Proteins - metabolism Immunoblotting Immunofluorescence Immunoglobulin G Infarction, Middle Cerebral Artery - complications Injection Injury prevention Ischemia Neuroprotection Occlusion Phagocytosis Pharmacology Proteins Rats Rats, Sprague-Dawley Reperfusion Reperfusion Injury - etiology Reperfusion Injury - metabolism Viruses Western blotting
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