Characterization and comparison of whey N-glycoproteomes from human and bovine colostrum and mature milk
•Whey N-glycoproteins were identified in human and bovine milk using glycoproteomics.•The bioinformatics analysis of the identified N-glycoproteins was conducted.•Immune-related N-glycoproteins were different in human and bovine milks.•Whey N-glycoproteomes varied between human and bovine milks acro...
Gespeichert in:
| Veröffentlicht in: | Food chemistry 2019-03, Vol.276, p.266-273 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 273 |
|---|---|
| container_issue | |
| container_start_page | 266 |
| container_title | Food chemistry |
| container_volume | 276 |
| creator | Cao, Xueyan Yang, Mei Yang, Ning Liang, Xiaona Tao, Dongbing Liu, Biao Wu, Junrui Yue, Xiqing |
| description | •Whey N-glycoproteins were identified in human and bovine milk using glycoproteomics.•The bioinformatics analysis of the identified N-glycoproteins was conducted.•Immune-related N-glycoproteins were different in human and bovine milks.•Whey N-glycoproteomes varied between human and bovine milks across lactation stages.
Milk glycoproteins are crucial nutrients with a variety of functions. However, whey N-glycoproteomes in human and bovine milks have not been characterized during lactation. Herein, using lectin enrichment and liquid chromatography tandem mass spectrometry, 68, 58, 100, and 98 N-glycoproteins were identified in human colostrum and mature milk as well as bovine colostrum and mature milk whey. Gene Ontology and KEGG pathway analyses were used to elucidate the biological functions of whey N-glycoproteins in human and bovine colostrum and mature milks. Whey N-glycoproteomes differed dramatically between human and bovine milks and across lactation stages. The conserved and specific whey N-glycoproteins in all four sample types were also determined. Our results improve understanding of the properties and biological functions of whey N-glycoproteins in human and bovine milk and colostra, and provide insight into the potential application of some N-glycoproteins in infant formulae at different stages of development. |
| doi_str_mv | 10.1016/j.foodchem.2018.09.174 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2132275684</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S030881461831759X</els_id><sourcerecordid>2132275684</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-91f3e30ab00db0133b55f3d72d778eaefd481d8386ab16cdbf18b02a083606883</originalsourceid><addsrcrecordid>eNqFkMtu2zAQRYmiQe0m-QVDy26kDkWZonYtjOYBBMkmWRMUOazoiqJLSi6cr49cO912RQxx7jwOISsKBQXKv24LG4LRHfqiBCoKaApaVx_Ikoqa5TXU5UeyBAYiF7TiC_I5pS0AHNlPZMGggmbdVEvSbToVlR4xulc1ujBkajCZDn6noktzGWz2p8ND9pj_7A867GIYMXhMmY3BZ93k1SnShr0bcE72IY1x8n8_vRqniJl3_a8rcmFVn_D6_F6Sl5sfz5u7_OHp9n7z_SHXjIsxb6hlyEC1AKYFyli7Xltm6tLUtUCF1lSCGsEEVy3l2rSWihZKBYJx4EKwS_Ll1Hfe9PeEaZTeJY19rwYMU5IlZWVZr7moZpSfUB1DShGt3EXnVTxICvJoWW7lu2V5NCehkbPlObg6z5haj-Zf7F3rDHw7AThfuncYZdIOB43GRdSjNMH9b8YbRJCTNQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2132275684</pqid></control><display><type>article</type><title>Characterization and comparison of whey N-glycoproteomes from human and bovine colostrum and mature milk</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Cao, Xueyan ; Yang, Mei ; Yang, Ning ; Liang, Xiaona ; Tao, Dongbing ; Liu, Biao ; Wu, Junrui ; Yue, Xiqing</creator><creatorcontrib>Cao, Xueyan ; Yang, Mei ; Yang, Ning ; Liang, Xiaona ; Tao, Dongbing ; Liu, Biao ; Wu, Junrui ; Yue, Xiqing</creatorcontrib><description>•Whey N-glycoproteins were identified in human and bovine milk using glycoproteomics.•The bioinformatics analysis of the identified N-glycoproteins was conducted.•Immune-related N-glycoproteins were different in human and bovine milks.•Whey N-glycoproteomes varied between human and bovine milks across lactation stages.
Milk glycoproteins are crucial nutrients with a variety of functions. However, whey N-glycoproteomes in human and bovine milks have not been characterized during lactation. Herein, using lectin enrichment and liquid chromatography tandem mass spectrometry, 68, 58, 100, and 98 N-glycoproteins were identified in human colostrum and mature milk as well as bovine colostrum and mature milk whey. Gene Ontology and KEGG pathway analyses were used to elucidate the biological functions of whey N-glycoproteins in human and bovine colostrum and mature milks. Whey N-glycoproteomes differed dramatically between human and bovine milks and across lactation stages. The conserved and specific whey N-glycoproteins in all four sample types were also determined. Our results improve understanding of the properties and biological functions of whey N-glycoproteins in human and bovine milk and colostra, and provide insight into the potential application of some N-glycoproteins in infant formulae at different stages of development.</description><identifier>ISSN: 0308-8146</identifier><identifier>EISSN: 1873-7072</identifier><identifier>DOI: 10.1016/j.foodchem.2018.09.174</identifier><identifier>PMID: 30409594</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Bovine ; Cattle ; Colostrum ; Colostrum - metabolism ; Female ; Glycoproteins - metabolism ; Glycoproteomics ; Human ; Humans ; Lactation ; Mature milk ; Milk, Human - metabolism ; Pregnancy ; Proteomics ; Whey N-glycoproteins ; Whey Proteins - metabolism</subject><ispartof>Food chemistry, 2019-03, Vol.276, p.266-273</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-91f3e30ab00db0133b55f3d72d778eaefd481d8386ab16cdbf18b02a083606883</citedby><cites>FETCH-LOGICAL-c368t-91f3e30ab00db0133b55f3d72d778eaefd481d8386ab16cdbf18b02a083606883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.foodchem.2018.09.174$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27913,27914,45984</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30409594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, Xueyan</creatorcontrib><creatorcontrib>Yang, Mei</creatorcontrib><creatorcontrib>Yang, Ning</creatorcontrib><creatorcontrib>Liang, Xiaona</creatorcontrib><creatorcontrib>Tao, Dongbing</creatorcontrib><creatorcontrib>Liu, Biao</creatorcontrib><creatorcontrib>Wu, Junrui</creatorcontrib><creatorcontrib>Yue, Xiqing</creatorcontrib><title>Characterization and comparison of whey N-glycoproteomes from human and bovine colostrum and mature milk</title><title>Food chemistry</title><addtitle>Food Chem</addtitle><description>•Whey N-glycoproteins were identified in human and bovine milk using glycoproteomics.•The bioinformatics analysis of the identified N-glycoproteins was conducted.•Immune-related N-glycoproteins were different in human and bovine milks.•Whey N-glycoproteomes varied between human and bovine milks across lactation stages.
Milk glycoproteins are crucial nutrients with a variety of functions. However, whey N-glycoproteomes in human and bovine milks have not been characterized during lactation. Herein, using lectin enrichment and liquid chromatography tandem mass spectrometry, 68, 58, 100, and 98 N-glycoproteins were identified in human colostrum and mature milk as well as bovine colostrum and mature milk whey. Gene Ontology and KEGG pathway analyses were used to elucidate the biological functions of whey N-glycoproteins in human and bovine colostrum and mature milks. Whey N-glycoproteomes differed dramatically between human and bovine milks and across lactation stages. The conserved and specific whey N-glycoproteins in all four sample types were also determined. Our results improve understanding of the properties and biological functions of whey N-glycoproteins in human and bovine milk and colostra, and provide insight into the potential application of some N-glycoproteins in infant formulae at different stages of development.</description><subject>Animals</subject><subject>Bovine</subject><subject>Cattle</subject><subject>Colostrum</subject><subject>Colostrum - metabolism</subject><subject>Female</subject><subject>Glycoproteins - metabolism</subject><subject>Glycoproteomics</subject><subject>Human</subject><subject>Humans</subject><subject>Lactation</subject><subject>Mature milk</subject><subject>Milk, Human - metabolism</subject><subject>Pregnancy</subject><subject>Proteomics</subject><subject>Whey N-glycoproteins</subject><subject>Whey Proteins - metabolism</subject><issn>0308-8146</issn><issn>1873-7072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtu2zAQRYmiQe0m-QVDy26kDkWZonYtjOYBBMkmWRMUOazoiqJLSi6cr49cO912RQxx7jwOISsKBQXKv24LG4LRHfqiBCoKaApaVx_Ikoqa5TXU5UeyBAYiF7TiC_I5pS0AHNlPZMGggmbdVEvSbToVlR4xulc1ujBkajCZDn6noktzGWz2p8ND9pj_7A867GIYMXhMmY3BZ93k1SnShr0bcE72IY1x8n8_vRqniJl3_a8rcmFVn_D6_F6Sl5sfz5u7_OHp9n7z_SHXjIsxb6hlyEC1AKYFyli7Xltm6tLUtUCF1lSCGsEEVy3l2rSWihZKBYJx4EKwS_Ll1Hfe9PeEaZTeJY19rwYMU5IlZWVZr7moZpSfUB1DShGt3EXnVTxICvJoWW7lu2V5NCehkbPlObg6z5haj-Zf7F3rDHw7AThfuncYZdIOB43GRdSjNMH9b8YbRJCTNQ</recordid><startdate>20190315</startdate><enddate>20190315</enddate><creator>Cao, Xueyan</creator><creator>Yang, Mei</creator><creator>Yang, Ning</creator><creator>Liang, Xiaona</creator><creator>Tao, Dongbing</creator><creator>Liu, Biao</creator><creator>Wu, Junrui</creator><creator>Yue, Xiqing</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190315</creationdate><title>Characterization and comparison of whey N-glycoproteomes from human and bovine colostrum and mature milk</title><author>Cao, Xueyan ; Yang, Mei ; Yang, Ning ; Liang, Xiaona ; Tao, Dongbing ; Liu, Biao ; Wu, Junrui ; Yue, Xiqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-91f3e30ab00db0133b55f3d72d778eaefd481d8386ab16cdbf18b02a083606883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Bovine</topic><topic>Cattle</topic><topic>Colostrum</topic><topic>Colostrum - metabolism</topic><topic>Female</topic><topic>Glycoproteins - metabolism</topic><topic>Glycoproteomics</topic><topic>Human</topic><topic>Humans</topic><topic>Lactation</topic><topic>Mature milk</topic><topic>Milk, Human - metabolism</topic><topic>Pregnancy</topic><topic>Proteomics</topic><topic>Whey N-glycoproteins</topic><topic>Whey Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao, Xueyan</creatorcontrib><creatorcontrib>Yang, Mei</creatorcontrib><creatorcontrib>Yang, Ning</creatorcontrib><creatorcontrib>Liang, Xiaona</creatorcontrib><creatorcontrib>Tao, Dongbing</creatorcontrib><creatorcontrib>Liu, Biao</creatorcontrib><creatorcontrib>Wu, Junrui</creatorcontrib><creatorcontrib>Yue, Xiqing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Xueyan</au><au>Yang, Mei</au><au>Yang, Ning</au><au>Liang, Xiaona</au><au>Tao, Dongbing</au><au>Liu, Biao</au><au>Wu, Junrui</au><au>Yue, Xiqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization and comparison of whey N-glycoproteomes from human and bovine colostrum and mature milk</atitle><jtitle>Food chemistry</jtitle><addtitle>Food Chem</addtitle><date>2019-03-15</date><risdate>2019</risdate><volume>276</volume><spage>266</spage><epage>273</epage><pages>266-273</pages><issn>0308-8146</issn><eissn>1873-7072</eissn><abstract>•Whey N-glycoproteins were identified in human and bovine milk using glycoproteomics.•The bioinformatics analysis of the identified N-glycoproteins was conducted.•Immune-related N-glycoproteins were different in human and bovine milks.•Whey N-glycoproteomes varied between human and bovine milks across lactation stages.
Milk glycoproteins are crucial nutrients with a variety of functions. However, whey N-glycoproteomes in human and bovine milks have not been characterized during lactation. Herein, using lectin enrichment and liquid chromatography tandem mass spectrometry, 68, 58, 100, and 98 N-glycoproteins were identified in human colostrum and mature milk as well as bovine colostrum and mature milk whey. Gene Ontology and KEGG pathway analyses were used to elucidate the biological functions of whey N-glycoproteins in human and bovine colostrum and mature milks. Whey N-glycoproteomes differed dramatically between human and bovine milks and across lactation stages. The conserved and specific whey N-glycoproteins in all four sample types were also determined. Our results improve understanding of the properties and biological functions of whey N-glycoproteins in human and bovine milk and colostra, and provide insight into the potential application of some N-glycoproteins in infant formulae at different stages of development.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30409594</pmid><doi>10.1016/j.foodchem.2018.09.174</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0308-8146 |
| ispartof | Food chemistry, 2019-03, Vol.276, p.266-273 |
| issn | 0308-8146 1873-7072 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2132275684 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Bovine Cattle Colostrum Colostrum - metabolism Female Glycoproteins - metabolism Glycoproteomics Human Humans Lactation Mature milk Milk, Human - metabolism Pregnancy Proteomics Whey N-glycoproteins Whey Proteins - metabolism |
| title | Characterization and comparison of whey N-glycoproteomes from human and bovine colostrum and mature milk |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T09%3A11%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characterization%20and%20comparison%20of%20whey%20N-glycoproteomes%20from%20human%20and%20bovine%20colostrum%20and%20mature%20milk&rft.jtitle=Food%20chemistry&rft.au=Cao,%20Xueyan&rft.date=2019-03-15&rft.volume=276&rft.spage=266&rft.epage=273&rft.pages=266-273&rft.issn=0308-8146&rft.eissn=1873-7072&rft_id=info:doi/10.1016/j.foodchem.2018.09.174&rft_dat=%3Cproquest_cross%3E2132275684%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2132275684&rft_id=info:pmid/30409594&rft_els_id=S030881461831759X&rfr_iscdi=true |