Assisted reproductive outcomes in women with different polycystic ovary syndrome phenotypes
Objective To explore assisted reproductive outcomes among women with different polycystic ovary syndrome (PCOS) phenotypes. Methods A retrospective cohort study included women with PCOS who were treated at Yazd Research and Clinical Center for Infertility, Yazd, Iran, using the GnRH antagonist proto...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 2019-02, Vol.144 (2), p.147-152 |
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| container_title | International journal of gynecology and obstetrics |
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| creator | Eftekhar, Maryam Mirhashemi, Elham S. Tabibnejad, Nasim |
| description | Objective
To explore assisted reproductive outcomes among women with different polycystic ovary syndrome (PCOS) phenotypes.
Methods
A retrospective cohort study included women with PCOS who were treated at Yazd Research and Clinical Center for Infertility, Yazd, Iran, using the GnRH antagonist protocol between April 1, 2015, and August 31, 2017. Clinical pregnancy was the primary outcome, and chemical pregnancy, implantation rate, fertilization rate, and spontaneous abortion rate, were the secondary outcomes that were evaluated among four defined phenotypes of women with PCOS.
Results
Significant differences were observed between the phenotypes for the levels of luteinizing hormone, anti‐Müllerian hormone, fasting blood sugar, and total testosterone concentration; similarly, the percentage of women with luteinizing hormone/follicle stimulating hormone ratio of at least 2.5 differed between PCOS phenotypes (all P |
| doi_str_mv | 10.1002/ijgo.12707 |
| format | Article |
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To explore assisted reproductive outcomes among women with different polycystic ovary syndrome (PCOS) phenotypes.
Methods
A retrospective cohort study included women with PCOS who were treated at Yazd Research and Clinical Center for Infertility, Yazd, Iran, using the GnRH antagonist protocol between April 1, 2015, and August 31, 2017. Clinical pregnancy was the primary outcome, and chemical pregnancy, implantation rate, fertilization rate, and spontaneous abortion rate, were the secondary outcomes that were evaluated among four defined phenotypes of women with PCOS.
Results
Significant differences were observed between the phenotypes for the levels of luteinizing hormone, anti‐Müllerian hormone, fasting blood sugar, and total testosterone concentration; similarly, the percentage of women with luteinizing hormone/follicle stimulating hormone ratio of at least 2.5 differed between PCOS phenotypes (all P<0.001). There were also significant differences in estradiol level (P<0.001) and the number of matured follicles (P=0.002) between different phenotypes. No significant differences were observed in the fertilization and implantation rates, as well as chemical and clinical pregnancy rates (all P>0.05).
Conclusion
No significant differences were observed in assisted reproductive technique outcome among women with different phenotypes of PCOS undergoing frozen‐thawed embryo transfer.
There were no significant differences in the outcome of assisted reproductive techniques among women with different phenotypes of polycystic ovary syndrome.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1002/ijgo.12707</identifier><identifier>PMID: 30411351</identifier><language>eng</language><publisher>United States</publisher><subject>Assisted reproductive technology ; Fertilization rate ; Implantation rate ; Ovarian hyperstimulation ; PCOS ; PCOS phenotypes ; Pregnancy rate ; Spontaneous abortion rate</subject><ispartof>International journal of gynecology and obstetrics, 2019-02, Vol.144 (2), p.147-152</ispartof><rights>2018 International Federation of Gynecology and Obstetrics</rights><rights>2018 International Federation of Gynecology and Obstetrics.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3297-b91312d95f2904e872c809cab765265bc0d441ace465548a1f1f0606f79fb9303</citedby><cites>FETCH-LOGICAL-c3297-b91312d95f2904e872c809cab765265bc0d441ace465548a1f1f0606f79fb9303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijgo.12707$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijgo.12707$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30411351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eftekhar, Maryam</creatorcontrib><creatorcontrib>Mirhashemi, Elham S.</creatorcontrib><creatorcontrib>Tabibnejad, Nasim</creatorcontrib><title>Assisted reproductive outcomes in women with different polycystic ovary syndrome phenotypes</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Objective
To explore assisted reproductive outcomes among women with different polycystic ovary syndrome (PCOS) phenotypes.
Methods
A retrospective cohort study included women with PCOS who were treated at Yazd Research and Clinical Center for Infertility, Yazd, Iran, using the GnRH antagonist protocol between April 1, 2015, and August 31, 2017. Clinical pregnancy was the primary outcome, and chemical pregnancy, implantation rate, fertilization rate, and spontaneous abortion rate, were the secondary outcomes that were evaluated among four defined phenotypes of women with PCOS.
Results
Significant differences were observed between the phenotypes for the levels of luteinizing hormone, anti‐Müllerian hormone, fasting blood sugar, and total testosterone concentration; similarly, the percentage of women with luteinizing hormone/follicle stimulating hormone ratio of at least 2.5 differed between PCOS phenotypes (all P<0.001). There were also significant differences in estradiol level (P<0.001) and the number of matured follicles (P=0.002) between different phenotypes. No significant differences were observed in the fertilization and implantation rates, as well as chemical and clinical pregnancy rates (all P>0.05).
Conclusion
No significant differences were observed in assisted reproductive technique outcome among women with different phenotypes of PCOS undergoing frozen‐thawed embryo transfer.
There were no significant differences in the outcome of assisted reproductive techniques among women with different phenotypes of polycystic ovary syndrome.</description><subject>Assisted reproductive technology</subject><subject>Fertilization rate</subject><subject>Implantation rate</subject><subject>Ovarian hyperstimulation</subject><subject>PCOS</subject><subject>PCOS phenotypes</subject><subject>Pregnancy rate</subject><subject>Spontaneous abortion rate</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQhi0EoqWw8AOQR4SU4nM-XI9VBaWoUheYGKLEOVNXaRzipFX-PS4tjCw-S_fcq7uHkFtgY2CMP5rNpx0DF0yckSFMhAzCSMhzMvRNFggu-YBcObdhjIEAuCSDkEUAYQxD8jF1zrgWC9pg3diiU63ZIbVdq-wWHTUV3fuPf027poXRGhusWlrbsle9a42idpc1PXV9VTSepPUaK9v2NbprcqGz0uHNqY7I-_PT2-wlWK7mi9l0GaiQSxHkEkLghYw1lyzCieBqwqTKcpHEPIlzxYoogkxhlMRxNMlAg2YJS7SQOpchC0fk_pjrD_jq0LXp1jiFZZlVaDuXcgg5T_yE9OjDEVWNda5BndaN2fr9U2DpQWZ6kJn-yPTw3Sm3y7dY_KG_9jwAR2BvSuz_iUoXr_PVMfQbTk6AUA</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Eftekhar, Maryam</creator><creator>Mirhashemi, Elham S.</creator><creator>Tabibnejad, Nasim</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201902</creationdate><title>Assisted reproductive outcomes in women with different polycystic ovary syndrome phenotypes</title><author>Eftekhar, Maryam ; Mirhashemi, Elham S. ; Tabibnejad, Nasim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3297-b91312d95f2904e872c809cab765265bc0d441ace465548a1f1f0606f79fb9303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Assisted reproductive technology</topic><topic>Fertilization rate</topic><topic>Implantation rate</topic><topic>Ovarian hyperstimulation</topic><topic>PCOS</topic><topic>PCOS phenotypes</topic><topic>Pregnancy rate</topic><topic>Spontaneous abortion rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eftekhar, Maryam</creatorcontrib><creatorcontrib>Mirhashemi, Elham S.</creatorcontrib><creatorcontrib>Tabibnejad, Nasim</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eftekhar, Maryam</au><au>Mirhashemi, Elham S.</au><au>Tabibnejad, Nasim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assisted reproductive outcomes in women with different polycystic ovary syndrome phenotypes</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2019-02</date><risdate>2019</risdate><volume>144</volume><issue>2</issue><spage>147</spage><epage>152</epage><pages>147-152</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><abstract>Objective
To explore assisted reproductive outcomes among women with different polycystic ovary syndrome (PCOS) phenotypes.
Methods
A retrospective cohort study included women with PCOS who were treated at Yazd Research and Clinical Center for Infertility, Yazd, Iran, using the GnRH antagonist protocol between April 1, 2015, and August 31, 2017. Clinical pregnancy was the primary outcome, and chemical pregnancy, implantation rate, fertilization rate, and spontaneous abortion rate, were the secondary outcomes that were evaluated among four defined phenotypes of women with PCOS.
Results
Significant differences were observed between the phenotypes for the levels of luteinizing hormone, anti‐Müllerian hormone, fasting blood sugar, and total testosterone concentration; similarly, the percentage of women with luteinizing hormone/follicle stimulating hormone ratio of at least 2.5 differed between PCOS phenotypes (all P<0.001). There were also significant differences in estradiol level (P<0.001) and the number of matured follicles (P=0.002) between different phenotypes. No significant differences were observed in the fertilization and implantation rates, as well as chemical and clinical pregnancy rates (all P>0.05).
Conclusion
No significant differences were observed in assisted reproductive technique outcome among women with different phenotypes of PCOS undergoing frozen‐thawed embryo transfer.
There were no significant differences in the outcome of assisted reproductive techniques among women with different phenotypes of polycystic ovary syndrome.</abstract><cop>United States</cop><pmid>30411351</pmid><doi>10.1002/ijgo.12707</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0020-7292 |
| ispartof | International journal of gynecology and obstetrics, 2019-02, Vol.144 (2), p.147-152 |
| issn | 0020-7292 1879-3479 |
| language | eng |
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| source | Wiley Journals |
| subjects | Assisted reproductive technology Fertilization rate Implantation rate Ovarian hyperstimulation PCOS PCOS phenotypes Pregnancy rate Spontaneous abortion rate |
| title | Assisted reproductive outcomes in women with different polycystic ovary syndrome phenotypes |
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