A secondary structure within a human piRNA modulates its functionality

The piwi-interacting RNAs (piRNAs) are small non-coding RNAs, mostly 24–32 nucleotides in length. The piRNAs are not known to have any conserved secondary structure or sequence motifs. Using bioinformatics analysis, we discovered the presence of putative G-quadruplex (GQ) forming sequences in human...

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Veröffentlicht in:	Biochimie 2019-02, Vol.157, p.72-80
Hauptverfasser:	Balaratnam, Sumirtha, Hettiarachchilage, Madara, West, Nicole, Piontkivska, Helen, Basu, Soumitra
Format:	Artikel
Sprache:	eng
Schlagworte:	G-quadruplex Gene silencing HIWI binding Piwi-interacting RNAs Secondary structure
Online-Zugang:	Volltext
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