Nationwide survey of congenital cholesteatoma using staging and classification criteria for middle ear cholesteatoma proposed by the Japan Otological Society

This study was undertaken to determine the characteristics of congenital cholesteatoma (CC) in Japan, via a nationwide survey using staging and classification criteria for middle ear cholesteatoma, as proposed by the Japan Otological Society (JOS). A nationwide survey regarding middle ear cholesteat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Auris, nasus, larynx nasus, larynx, 2019-06, Vol.46 (3), p.346-352
Hauptverfasser: Morita, Yuka, Tono, Tetsuya, Sakagami, Masafumi, Yamamoto, Yutaka, Matsuda, Keiji, Komori, Manabu, Hato, Naohito, Hashimoto, Sho, Takahashi, Haruo, Kojima, Hiromi
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 352
container_issue 3
container_start_page 346
container_title Auris, nasus, larynx
container_volume 46
creator Morita, Yuka
Tono, Tetsuya
Sakagami, Masafumi
Yamamoto, Yutaka
Matsuda, Keiji
Komori, Manabu
Hato, Naohito
Hashimoto, Sho
Takahashi, Haruo
Kojima, Hiromi
description This study was undertaken to determine the characteristics of congenital cholesteatoma (CC) in Japan, via a nationwide survey using staging and classification criteria for middle ear cholesteatoma, as proposed by the Japan Otological Society (JOS). A nationwide survey regarding middle ear cholesteatoma treated in 2015 was performed. There were 1787 registrations from 74 facilities, among which, CC accounted for 12.9% (231 cases) of all middle ear cholesteatoma cases. The extent of the disease was classified according to the classification and staging of cholesteatoma proposed by JOS in 2015. The age of the patients ranged from 1 to 55 years (mean, 8.2 years; median, 6 years; 149 ears of males; 82 ears of females). Among these cases, 105 (45.5%) were classified as stage I, 121 (52.4%) as stage II, and 5 (2.1%) as stage III, with no cases in stage IV. In the sub classification of stage I, 35 (33%), 43 (41%) and 27 (26%) ears were classified as stages I-a, I-b and I-c, respectively. Stage I-b (cholesteatoma confined to the posterior half of the tympanic cavity) was more frequent than stage I-a (the anterior half of tympanic cavity). Pre-operative hearing level of air-conduction was 20.5dB for stage I-a, 34.5dB for stage I-b, 30.5dB for stage I-c, 38.6dB for stage II, and 59.0dB for stage III. The rate of missing stapes superstructure increased as the disease progressed. In the same way, the mastoid development lowered as the stage of the disease progressed. There were significant differences in the age at operation, pre-operative hearing level, status of stapes, and major ossiculoplasty, between stage l-a and l-b. The current condition of CC in Japan was been evaluated; in particular, it was observed that the cases limited to the posterior part of tympanic cavity were not rare. The JOS stage classification based on the progression of the disease seemed simple and efficient.
doi_str_mv 10.1016/j.anl.2018.10.015
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2132259201</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0385814618306412</els_id><sourcerecordid>2132259201</sourcerecordid><originalsourceid>FETCH-LOGICAL-c443t-f9b8c7484c274144ca71e516e471640e0e19471ecfbbfae3a3a30d87ec6c2f1b3</originalsourceid><addsrcrecordid>eNp9kU1vFDEMhiNERZfCD-CCcuQySzyTnQ9xQhWfquihcI48iWebVSZZkkzR_pj-V7Js4cCh8sF29PqRnZexVyDWIKB9u1ujd-taQF_6tYDNE7aCvhsqkF37lK1E02-qHmR7zp6ntBNCNF0zPGPnjZDQilqu2P03zDb4X9YQT0u8owMPE9fBb8nbjI7r2-AoZcIcZuRLsn7LU8btMaM3XDtMyU5W_-FwHW2maJFPIfLZGuOIE8b_MPsY9iGR4eOB51viX3GPnl_n4MK2kBy_CdpSPrxgZxO6RC8f8gX78fHD98vP1dX1py-X768qLWWTq2kYe93JXuq6kyClxg5oAy3JDlopSBAMpSQ9jeOE1GAJYfqOdKvrCcbmgr05cctiP5eyp5pt0uQcegpLUjU0db0Zyk8XKZykOoaUIk1qH-2M8aBAqKMraqeKK-royvGpuFJmXj_gl3Em82_irw1F8O4koHLknaWoUrnfazI2ks7KBPsI_jeDQKGG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2132259201</pqid></control><display><type>article</type><title>Nationwide survey of congenital cholesteatoma using staging and classification criteria for middle ear cholesteatoma proposed by the Japan Otological Society</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Morita, Yuka ; Tono, Tetsuya ; Sakagami, Masafumi ; Yamamoto, Yutaka ; Matsuda, Keiji ; Komori, Manabu ; Hato, Naohito ; Hashimoto, Sho ; Takahashi, Haruo ; Kojima, Hiromi</creator><creatorcontrib>Morita, Yuka ; Tono, Tetsuya ; Sakagami, Masafumi ; Yamamoto, Yutaka ; Matsuda, Keiji ; Komori, Manabu ; Hato, Naohito ; Hashimoto, Sho ; Takahashi, Haruo ; Kojima, Hiromi</creatorcontrib><description>This study was undertaken to determine the characteristics of congenital cholesteatoma (CC) in Japan, via a nationwide survey using staging and classification criteria for middle ear cholesteatoma, as proposed by the Japan Otological Society (JOS). A nationwide survey regarding middle ear cholesteatoma treated in 2015 was performed. There were 1787 registrations from 74 facilities, among which, CC accounted for 12.9% (231 cases) of all middle ear cholesteatoma cases. The extent of the disease was classified according to the classification and staging of cholesteatoma proposed by JOS in 2015. The age of the patients ranged from 1 to 55 years (mean, 8.2 years; median, 6 years; 149 ears of males; 82 ears of females). Among these cases, 105 (45.5%) were classified as stage I, 121 (52.4%) as stage II, and 5 (2.1%) as stage III, with no cases in stage IV. In the sub classification of stage I, 35 (33%), 43 (41%) and 27 (26%) ears were classified as stages I-a, I-b and I-c, respectively. Stage I-b (cholesteatoma confined to the posterior half of the tympanic cavity) was more frequent than stage I-a (the anterior half of tympanic cavity). Pre-operative hearing level of air-conduction was 20.5dB for stage I-a, 34.5dB for stage I-b, 30.5dB for stage I-c, 38.6dB for stage II, and 59.0dB for stage III. The rate of missing stapes superstructure increased as the disease progressed. In the same way, the mastoid development lowered as the stage of the disease progressed. There were significant differences in the age at operation, pre-operative hearing level, status of stapes, and major ossiculoplasty, between stage l-a and l-b. The current condition of CC in Japan was been evaluated; in particular, it was observed that the cases limited to the posterior part of tympanic cavity were not rare. The JOS stage classification based on the progression of the disease seemed simple and efficient.</description><identifier>ISSN: 0385-8146</identifier><identifier>EISSN: 1879-1476</identifier><identifier>DOI: 10.1016/j.anl.2018.10.015</identifier><identifier>PMID: 30416024</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Audiometry, Pure-Tone ; Child ; Child, Preschool ; Cholesteatoma - complications ; Cholesteatoma - congenital ; Cholesteatoma - pathology ; Cholesteatoma - physiopathology ; Cholesteatoma - surgery ; Cholesteatoma, Middle Ear - complications ; Cholesteatoma, Middle Ear - pathology ; Cholesteatoma, Middle Ear - physiopathology ; Cholesteatoma, Middle Ear - surgery ; Congenital cholesteatoma ; Ear, Middle ; Female ; Hearing Loss - etiology ; Hearing Loss - physiopathology ; Humans ; Infant ; Japan ; Male ; Mastoid development ; Mastoidectomy ; Middle Aged ; Nationwide survey ; Ossicular Replacement ; Severity of Illness Index ; Stage classification ; Surgical treatment ; Tympanoplasty ; Young Adult</subject><ispartof>Auris, nasus, larynx, 2019-06, Vol.46 (3), p.346-352</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-f9b8c7484c274144ca71e516e471640e0e19471ecfbbfae3a3a30d87ec6c2f1b3</citedby><cites>FETCH-LOGICAL-c443t-f9b8c7484c274144ca71e516e471640e0e19471ecfbbfae3a3a30d87ec6c2f1b3</cites><orcidid>0000-0002-4577-1234 ; 0000-0001-8223-9186</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0385814618306412$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30416024$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morita, Yuka</creatorcontrib><creatorcontrib>Tono, Tetsuya</creatorcontrib><creatorcontrib>Sakagami, Masafumi</creatorcontrib><creatorcontrib>Yamamoto, Yutaka</creatorcontrib><creatorcontrib>Matsuda, Keiji</creatorcontrib><creatorcontrib>Komori, Manabu</creatorcontrib><creatorcontrib>Hato, Naohito</creatorcontrib><creatorcontrib>Hashimoto, Sho</creatorcontrib><creatorcontrib>Takahashi, Haruo</creatorcontrib><creatorcontrib>Kojima, Hiromi</creatorcontrib><title>Nationwide survey of congenital cholesteatoma using staging and classification criteria for middle ear cholesteatoma proposed by the Japan Otological Society</title><title>Auris, nasus, larynx</title><addtitle>Auris Nasus Larynx</addtitle><description>This study was undertaken to determine the characteristics of congenital cholesteatoma (CC) in Japan, via a nationwide survey using staging and classification criteria for middle ear cholesteatoma, as proposed by the Japan Otological Society (JOS). A nationwide survey regarding middle ear cholesteatoma treated in 2015 was performed. There were 1787 registrations from 74 facilities, among which, CC accounted for 12.9% (231 cases) of all middle ear cholesteatoma cases. The extent of the disease was classified according to the classification and staging of cholesteatoma proposed by JOS in 2015. The age of the patients ranged from 1 to 55 years (mean, 8.2 years; median, 6 years; 149 ears of males; 82 ears of females). Among these cases, 105 (45.5%) were classified as stage I, 121 (52.4%) as stage II, and 5 (2.1%) as stage III, with no cases in stage IV. In the sub classification of stage I, 35 (33%), 43 (41%) and 27 (26%) ears were classified as stages I-a, I-b and I-c, respectively. Stage I-b (cholesteatoma confined to the posterior half of the tympanic cavity) was more frequent than stage I-a (the anterior half of tympanic cavity). Pre-operative hearing level of air-conduction was 20.5dB for stage I-a, 34.5dB for stage I-b, 30.5dB for stage I-c, 38.6dB for stage II, and 59.0dB for stage III. The rate of missing stapes superstructure increased as the disease progressed. In the same way, the mastoid development lowered as the stage of the disease progressed. There were significant differences in the age at operation, pre-operative hearing level, status of stapes, and major ossiculoplasty, between stage l-a and l-b. The current condition of CC in Japan was been evaluated; in particular, it was observed that the cases limited to the posterior part of tympanic cavity were not rare. The JOS stage classification based on the progression of the disease seemed simple and efficient.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Audiometry, Pure-Tone</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cholesteatoma - complications</subject><subject>Cholesteatoma - congenital</subject><subject>Cholesteatoma - pathology</subject><subject>Cholesteatoma - physiopathology</subject><subject>Cholesteatoma - surgery</subject><subject>Cholesteatoma, Middle Ear - complications</subject><subject>Cholesteatoma, Middle Ear - pathology</subject><subject>Cholesteatoma, Middle Ear - physiopathology</subject><subject>Cholesteatoma, Middle Ear - surgery</subject><subject>Congenital cholesteatoma</subject><subject>Ear, Middle</subject><subject>Female</subject><subject>Hearing Loss - etiology</subject><subject>Hearing Loss - physiopathology</subject><subject>Humans</subject><subject>Infant</subject><subject>Japan</subject><subject>Male</subject><subject>Mastoid development</subject><subject>Mastoidectomy</subject><subject>Middle Aged</subject><subject>Nationwide survey</subject><subject>Ossicular Replacement</subject><subject>Severity of Illness Index</subject><subject>Stage classification</subject><subject>Surgical treatment</subject><subject>Tympanoplasty</subject><subject>Young Adult</subject><issn>0385-8146</issn><issn>1879-1476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1vFDEMhiNERZfCD-CCcuQySzyTnQ9xQhWfquihcI48iWebVSZZkkzR_pj-V7Js4cCh8sF29PqRnZexVyDWIKB9u1ujd-taQF_6tYDNE7aCvhsqkF37lK1E02-qHmR7zp6ntBNCNF0zPGPnjZDQilqu2P03zDb4X9YQT0u8owMPE9fBb8nbjI7r2-AoZcIcZuRLsn7LU8btMaM3XDtMyU5W_-FwHW2maJFPIfLZGuOIE8b_MPsY9iGR4eOB51viX3GPnl_n4MK2kBy_CdpSPrxgZxO6RC8f8gX78fHD98vP1dX1py-X768qLWWTq2kYe93JXuq6kyClxg5oAy3JDlopSBAMpSQ9jeOE1GAJYfqOdKvrCcbmgr05cctiP5eyp5pt0uQcegpLUjU0db0Zyk8XKZykOoaUIk1qH-2M8aBAqKMraqeKK-royvGpuFJmXj_gl3Em82_irw1F8O4koHLknaWoUrnfazI2ks7KBPsI_jeDQKGG</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Morita, Yuka</creator><creator>Tono, Tetsuya</creator><creator>Sakagami, Masafumi</creator><creator>Yamamoto, Yutaka</creator><creator>Matsuda, Keiji</creator><creator>Komori, Manabu</creator><creator>Hato, Naohito</creator><creator>Hashimoto, Sho</creator><creator>Takahashi, Haruo</creator><creator>Kojima, Hiromi</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4577-1234</orcidid><orcidid>https://orcid.org/0000-0001-8223-9186</orcidid></search><sort><creationdate>201906</creationdate><title>Nationwide survey of congenital cholesteatoma using staging and classification criteria for middle ear cholesteatoma proposed by the Japan Otological Society</title><author>Morita, Yuka ; Tono, Tetsuya ; Sakagami, Masafumi ; Yamamoto, Yutaka ; Matsuda, Keiji ; Komori, Manabu ; Hato, Naohito ; Hashimoto, Sho ; Takahashi, Haruo ; Kojima, Hiromi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-f9b8c7484c274144ca71e516e471640e0e19471ecfbbfae3a3a30d87ec6c2f1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Audiometry, Pure-Tone</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cholesteatoma - complications</topic><topic>Cholesteatoma - congenital</topic><topic>Cholesteatoma - pathology</topic><topic>Cholesteatoma - physiopathology</topic><topic>Cholesteatoma - surgery</topic><topic>Cholesteatoma, Middle Ear - complications</topic><topic>Cholesteatoma, Middle Ear - pathology</topic><topic>Cholesteatoma, Middle Ear - physiopathology</topic><topic>Cholesteatoma, Middle Ear - surgery</topic><topic>Congenital cholesteatoma</topic><topic>Ear, Middle</topic><topic>Female</topic><topic>Hearing Loss - etiology</topic><topic>Hearing Loss - physiopathology</topic><topic>Humans</topic><topic>Infant</topic><topic>Japan</topic><topic>Male</topic><topic>Mastoid development</topic><topic>Mastoidectomy</topic><topic>Middle Aged</topic><topic>Nationwide survey</topic><topic>Ossicular Replacement</topic><topic>Severity of Illness Index</topic><topic>Stage classification</topic><topic>Surgical treatment</topic><topic>Tympanoplasty</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morita, Yuka</creatorcontrib><creatorcontrib>Tono, Tetsuya</creatorcontrib><creatorcontrib>Sakagami, Masafumi</creatorcontrib><creatorcontrib>Yamamoto, Yutaka</creatorcontrib><creatorcontrib>Matsuda, Keiji</creatorcontrib><creatorcontrib>Komori, Manabu</creatorcontrib><creatorcontrib>Hato, Naohito</creatorcontrib><creatorcontrib>Hashimoto, Sho</creatorcontrib><creatorcontrib>Takahashi, Haruo</creatorcontrib><creatorcontrib>Kojima, Hiromi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Auris, nasus, larynx</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morita, Yuka</au><au>Tono, Tetsuya</au><au>Sakagami, Masafumi</au><au>Yamamoto, Yutaka</au><au>Matsuda, Keiji</au><au>Komori, Manabu</au><au>Hato, Naohito</au><au>Hashimoto, Sho</au><au>Takahashi, Haruo</au><au>Kojima, Hiromi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nationwide survey of congenital cholesteatoma using staging and classification criteria for middle ear cholesteatoma proposed by the Japan Otological Society</atitle><jtitle>Auris, nasus, larynx</jtitle><addtitle>Auris Nasus Larynx</addtitle><date>2019-06</date><risdate>2019</risdate><volume>46</volume><issue>3</issue><spage>346</spage><epage>352</epage><pages>346-352</pages><issn>0385-8146</issn><eissn>1879-1476</eissn><abstract>This study was undertaken to determine the characteristics of congenital cholesteatoma (CC) in Japan, via a nationwide survey using staging and classification criteria for middle ear cholesteatoma, as proposed by the Japan Otological Society (JOS). A nationwide survey regarding middle ear cholesteatoma treated in 2015 was performed. There were 1787 registrations from 74 facilities, among which, CC accounted for 12.9% (231 cases) of all middle ear cholesteatoma cases. The extent of the disease was classified according to the classification and staging of cholesteatoma proposed by JOS in 2015. The age of the patients ranged from 1 to 55 years (mean, 8.2 years; median, 6 years; 149 ears of males; 82 ears of females). Among these cases, 105 (45.5%) were classified as stage I, 121 (52.4%) as stage II, and 5 (2.1%) as stage III, with no cases in stage IV. In the sub classification of stage I, 35 (33%), 43 (41%) and 27 (26%) ears were classified as stages I-a, I-b and I-c, respectively. Stage I-b (cholesteatoma confined to the posterior half of the tympanic cavity) was more frequent than stage I-a (the anterior half of tympanic cavity). Pre-operative hearing level of air-conduction was 20.5dB for stage I-a, 34.5dB for stage I-b, 30.5dB for stage I-c, 38.6dB for stage II, and 59.0dB for stage III. The rate of missing stapes superstructure increased as the disease progressed. In the same way, the mastoid development lowered as the stage of the disease progressed. There were significant differences in the age at operation, pre-operative hearing level, status of stapes, and major ossiculoplasty, between stage l-a and l-b. The current condition of CC in Japan was been evaluated; in particular, it was observed that the cases limited to the posterior part of tympanic cavity were not rare. The JOS stage classification based on the progression of the disease seemed simple and efficient.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30416024</pmid><doi>10.1016/j.anl.2018.10.015</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4577-1234</orcidid><orcidid>https://orcid.org/0000-0001-8223-9186</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0385-8146
ispartof Auris, nasus, larynx, 2019-06, Vol.46 (3), p.346-352
issn 0385-8146
1879-1476
language eng
recordid cdi_proquest_miscellaneous_2132259201
source MEDLINE; Elsevier ScienceDirect Journals
subjects Adolescent
Adult
Audiometry, Pure-Tone
Child
Child, Preschool
Cholesteatoma - complications
Cholesteatoma - congenital
Cholesteatoma - pathology
Cholesteatoma - physiopathology
Cholesteatoma - surgery
Cholesteatoma, Middle Ear - complications
Cholesteatoma, Middle Ear - pathology
Cholesteatoma, Middle Ear - physiopathology
Cholesteatoma, Middle Ear - surgery
Congenital cholesteatoma
Ear, Middle
Female
Hearing Loss - etiology
Hearing Loss - physiopathology
Humans
Infant
Japan
Male
Mastoid development
Mastoidectomy
Middle Aged
Nationwide survey
Ossicular Replacement
Severity of Illness Index
Stage classification
Surgical treatment
Tympanoplasty
Young Adult
title Nationwide survey of congenital cholesteatoma using staging and classification criteria for middle ear cholesteatoma proposed by the Japan Otological Society
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T17%3A32%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nationwide%20survey%20of%20congenital%20cholesteatoma%20using%20staging%20and%20classification%20criteria%20for%20middle%20ear%20cholesteatoma%20proposed%20by%20the%20Japan%20Otological%20Society&rft.jtitle=Auris,%20nasus,%20larynx&rft.au=Morita,%20Yuka&rft.date=2019-06&rft.volume=46&rft.issue=3&rft.spage=346&rft.epage=352&rft.pages=346-352&rft.issn=0385-8146&rft.eissn=1879-1476&rft_id=info:doi/10.1016/j.anl.2018.10.015&rft_dat=%3Cproquest_cross%3E2132259201%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2132259201&rft_id=info:pmid/30416024&rft_els_id=S0385814618306412&rfr_iscdi=true