Sulfonyl(thio)urea derivative induction of insulin secretion is mediated by potassium, calcium, and sodium channel signal transduction

Aim To investigate the mechanism of action of sulfonyl(thio)urea derivative (SD) on glycemia and on insulin secretion in pancreatic islets. Methods Wistar rats were divided into hyperglycemic control group, rats received 4 g/kg body weight glucose plus sitagliptin 10 mg/kg (p.o.); hyperglycemic plus...

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Veröffentlicht in:Journal of cellular physiology 2019-07, Vol.234 (7), p.10138-10147
Hauptverfasser: Sulis, Paola Miranda, Dambrós, Betina Fernanda, Mascarello, Alessandra, dos Santos, Adair Roberto Soares, Yunes, Rosendo Augusto, Nunes, Ricardo José, Frederico, Marisa Jádna Silva, Barreto Silva, Fátima Regina Mena
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container_end_page 10147
container_issue 7
container_start_page 10138
container_title Journal of cellular physiology
container_volume 234
creator Sulis, Paola Miranda
Dambrós, Betina Fernanda
Mascarello, Alessandra
dos Santos, Adair Roberto Soares
Yunes, Rosendo Augusto
Nunes, Ricardo José
Frederico, Marisa Jádna Silva
Barreto Silva, Fátima Regina Mena
description Aim To investigate the mechanism of action of sulfonyl(thio)urea derivative (SD) on glycemia and on insulin secretion in pancreatic islets. Methods Wistar rats were divided into hyperglycemic control group, rats received 4 g/kg body weight glucose plus sitagliptin 10 mg/kg (p.o.); hyperglycemic plus SD 10 mg/kg (p.o.); hyperglycemic plus SD plus sitagliptin. Blood was collected before glucose overloading (zero time), and at 15, 30, 60, and 180 min after glucose, from the afore mentioned groups for glycemia and glucagon‐like peptide 1 (GLP‐1) measurements and intestinal disaccharidases activity. Pancreatic islets were isolated for the calcium influx and insulin secretion in in vitro studies. Results SD reduced glycemia and increased GLP‐1 secretion, while inhibited sucrase and lactase activity. This SD (1.0 and 10.0 µM) stimulated calcium influx in a similar percentile to that of glibenclamide, and in a nonsynergic manner. In addition, the trigger effect of SD on calcium influx was through the K+‐ATP‐dependent channels, and partially by activating voltage‐dependent K + channels and voltage‐dependent calcium channels. Furthermore, SD‐stimulated Na + and Ca 2+ entry, induced by the transient receptor potential ankyrin 1 and by modulation of Na +/Ca 2+ exchange. The activation of these pathways by SD culminated in in vitro insulin secretion, reinforcing the critical role of K +‐ATP channels in the secretagogue effect of SD. Conclusions SD diminish glycemia by inducing GLP‐1 secretion and inhibiting disaccharidases. To our knowledge, this is the first report of an insulin secretagogue effect of SD that is mediated by potassium and calcium, as well as sodium, signal transduction. Sulfonyl(thio)urea derivative (SD) stimulates insulin secretion. Mechanism of action of SD on insulin secretion is mediated by potassium, calcium, and sodium.
doi_str_mv 10.1002/jcp.27680
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Methods Wistar rats were divided into hyperglycemic control group, rats received 4 g/kg body weight glucose plus sitagliptin 10 mg/kg (p.o.); hyperglycemic plus SD 10 mg/kg (p.o.); hyperglycemic plus SD plus sitagliptin. Blood was collected before glucose overloading (zero time), and at 15, 30, 60, and 180 min after glucose, from the afore mentioned groups for glycemia and glucagon‐like peptide 1 (GLP‐1) measurements and intestinal disaccharidases activity. Pancreatic islets were isolated for the calcium influx and insulin secretion in in vitro studies. Results SD reduced glycemia and increased GLP‐1 secretion, while inhibited sucrase and lactase activity. This SD (1.0 and 10.0 µM) stimulated calcium influx in a similar percentile to that of glibenclamide, and in a nonsynergic manner. In addition, the trigger effect of SD on calcium influx was through the K+‐ATP‐dependent channels, and partially by activating voltage‐dependent K + channels and voltage‐dependent calcium channels. Furthermore, SD‐stimulated Na + and Ca 2+ entry, induced by the transient receptor potential ankyrin 1 and by modulation of Na +/Ca 2+ exchange. The activation of these pathways by SD culminated in in vitro insulin secretion, reinforcing the critical role of K +‐ATP channels in the secretagogue effect of SD. Conclusions SD diminish glycemia by inducing GLP‐1 secretion and inhibiting disaccharidases. To our knowledge, this is the first report of an insulin secretagogue effect of SD that is mediated by potassium and calcium, as well as sodium, signal transduction. Sulfonyl(thio)urea derivative (SD) stimulates insulin secretion. Mechanism of action of SD on insulin secretion is mediated by potassium, calcium, and sodium.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.27680</identifier><identifier>PMID: 30417369</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; Ankyrins ; ATP ; Blood glucose ; Body weight ; Calcium channels ; Calcium channels (voltage-gated) ; Calcium Channels - drug effects ; Calcium Channels - metabolism ; Calcium influx ; Calcium ions ; Calcium signalling ; Channels ; Electric potential ; Glibenclamide ; Glucagon ; Glucagon-Like Peptide 1 - metabolism ; Glucose ; Hyperglycemia - metabolism ; Hypoglycemic Agents - pharmacology ; Insulin ; insulin secretagogue ; Insulin secretion ; Insulin Secretion - drug effects ; Intestine ; Islets of Langerhans - drug effects ; Islets of Langerhans - metabolism ; Lactase ; Male ; Overloading ; Pancreas ; Potassium ; potassium channels ; Potassium channels (voltage-gated) ; Potassium Channels, Voltage-Gated - drug effects ; Potassium Channels, Voltage-Gated - metabolism ; Rats ; Rats, Wistar ; Rodents ; Secretion ; Signal transduction ; Signal Transduction - drug effects ; Sitagliptin Phosphate - pharmacology ; Sodium ; sodium channels ; sulfonyl(thio)urea ; Sulfonylurea Compounds - pharmacology ; Transient receptor potential proteins ; Urea ; VDCC ; Voltage-Gated Sodium Channels - drug effects ; Voltage-Gated Sodium Channels - metabolism</subject><ispartof>Journal of cellular physiology, 2019-07, Vol.234 (7), p.10138-10147</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3530-dd9c4f86a828bd641e15e4f33d96107d1597963b8d7d4efbdb2819fa7b1f28e43</citedby><cites>FETCH-LOGICAL-c3530-dd9c4f86a828bd641e15e4f33d96107d1597963b8d7d4efbdb2819fa7b1f28e43</cites><orcidid>0000-0002-1391-2354</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.27680$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.27680$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30417369$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sulis, Paola Miranda</creatorcontrib><creatorcontrib>Dambrós, Betina Fernanda</creatorcontrib><creatorcontrib>Mascarello, Alessandra</creatorcontrib><creatorcontrib>dos Santos, Adair Roberto Soares</creatorcontrib><creatorcontrib>Yunes, Rosendo Augusto</creatorcontrib><creatorcontrib>Nunes, Ricardo José</creatorcontrib><creatorcontrib>Frederico, Marisa Jádna Silva</creatorcontrib><creatorcontrib>Barreto Silva, Fátima Regina Mena</creatorcontrib><title>Sulfonyl(thio)urea derivative induction of insulin secretion is mediated by potassium, calcium, and sodium channel signal transduction</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Aim To investigate the mechanism of action of sulfonyl(thio)urea derivative (SD) on glycemia and on insulin secretion in pancreatic islets. Methods Wistar rats were divided into hyperglycemic control group, rats received 4 g/kg body weight glucose plus sitagliptin 10 mg/kg (p.o.); hyperglycemic plus SD 10 mg/kg (p.o.); hyperglycemic plus SD plus sitagliptin. Blood was collected before glucose overloading (zero time), and at 15, 30, 60, and 180 min after glucose, from the afore mentioned groups for glycemia and glucagon‐like peptide 1 (GLP‐1) measurements and intestinal disaccharidases activity. Pancreatic islets were isolated for the calcium influx and insulin secretion in in vitro studies. Results SD reduced glycemia and increased GLP‐1 secretion, while inhibited sucrase and lactase activity. This SD (1.0 and 10.0 µM) stimulated calcium influx in a similar percentile to that of glibenclamide, and in a nonsynergic manner. In addition, the trigger effect of SD on calcium influx was through the K+‐ATP‐dependent channels, and partially by activating voltage‐dependent K + channels and voltage‐dependent calcium channels. Furthermore, SD‐stimulated Na + and Ca 2+ entry, induced by the transient receptor potential ankyrin 1 and by modulation of Na +/Ca 2+ exchange. The activation of these pathways by SD culminated in in vitro insulin secretion, reinforcing the critical role of K +‐ATP channels in the secretagogue effect of SD. Conclusions SD diminish glycemia by inducing GLP‐1 secretion and inhibiting disaccharidases. To our knowledge, this is the first report of an insulin secretagogue effect of SD that is mediated by potassium and calcium, as well as sodium, signal transduction. Sulfonyl(thio)urea derivative (SD) stimulates insulin secretion. Mechanism of action of SD on insulin secretion is mediated by potassium, calcium, and sodium.</description><subject>Animals</subject><subject>Ankyrins</subject><subject>ATP</subject><subject>Blood glucose</subject><subject>Body weight</subject><subject>Calcium channels</subject><subject>Calcium channels (voltage-gated)</subject><subject>Calcium Channels - drug effects</subject><subject>Calcium Channels - metabolism</subject><subject>Calcium influx</subject><subject>Calcium ions</subject><subject>Calcium signalling</subject><subject>Channels</subject><subject>Electric potential</subject><subject>Glibenclamide</subject><subject>Glucagon</subject><subject>Glucagon-Like Peptide 1 - metabolism</subject><subject>Glucose</subject><subject>Hyperglycemia - metabolism</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Insulin</subject><subject>insulin secretagogue</subject><subject>Insulin secretion</subject><subject>Insulin Secretion - drug effects</subject><subject>Intestine</subject><subject>Islets of Langerhans - drug effects</subject><subject>Islets of Langerhans - metabolism</subject><subject>Lactase</subject><subject>Male</subject><subject>Overloading</subject><subject>Pancreas</subject><subject>Potassium</subject><subject>potassium channels</subject><subject>Potassium channels (voltage-gated)</subject><subject>Potassium Channels, Voltage-Gated - drug effects</subject><subject>Potassium Channels, Voltage-Gated - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Secretion</subject><subject>Signal transduction</subject><subject>Signal Transduction - drug effects</subject><subject>Sitagliptin Phosphate - pharmacology</subject><subject>Sodium</subject><subject>sodium channels</subject><subject>sulfonyl(thio)urea</subject><subject>Sulfonylurea Compounds - pharmacology</subject><subject>Transient receptor potential proteins</subject><subject>Urea</subject><subject>VDCC</subject><subject>Voltage-Gated Sodium Channels - drug effects</subject><subject>Voltage-Gated Sodium Channels - metabolism</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kdtKXDEUhkOx1NH2oi9QAt4ouDWHfcqlDNYDgkLb6012slIzZJJpsqPMC_jcjTNTL4RerbWSj4_F-hH6SskZJYSdL9TqjHVtTz6gGSWiq-q2YXtoVv5oJZqa7qODlBaEECE4_4T2Oalpx1sxQy8_sjPBr93x9GjDSY4gsYZon-RknwBbr7OabPA4mDKk7KzHCVSEzaNNeAnaygk0Htd4FSaZks3LU6ykU5tGeo1T0KXH6lF6Dw4n-9tLh6cofdrpP6OPRroEX3b1EP36fvlzfl3d3V_dzC_uKsUbTiqthapN38qe9aNuawq0gdpwrkVLSadpIzrR8rHXna7BjHpkPRVGdiM1rIeaH6LjrXcVw58MaRqWNilwTnoIOQ2McsYaQRgv6NE7dBFyLIu_UuWMhPOWFOpkS6kYUopghlW0SxnXAyXDazhDCWfYhFPYbztjHsvZ3sh_aRTgfAs8Wwfr_5uG2_nDVvkX03Oa1w</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Sulis, Paola Miranda</creator><creator>Dambrós, Betina Fernanda</creator><creator>Mascarello, Alessandra</creator><creator>dos Santos, Adair Roberto Soares</creator><creator>Yunes, Rosendo Augusto</creator><creator>Nunes, Ricardo José</creator><creator>Frederico, Marisa Jádna Silva</creator><creator>Barreto Silva, Fátima Regina Mena</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1391-2354</orcidid></search><sort><creationdate>201907</creationdate><title>Sulfonyl(thio)urea derivative induction of insulin secretion is mediated by potassium, calcium, and sodium channel signal transduction</title><author>Sulis, Paola Miranda ; Dambrós, Betina Fernanda ; Mascarello, Alessandra ; dos Santos, Adair Roberto Soares ; Yunes, Rosendo Augusto ; Nunes, Ricardo José ; Frederico, Marisa Jádna Silva ; Barreto Silva, Fátima Regina Mena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3530-dd9c4f86a828bd641e15e4f33d96107d1597963b8d7d4efbdb2819fa7b1f28e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Ankyrins</topic><topic>ATP</topic><topic>Blood glucose</topic><topic>Body weight</topic><topic>Calcium channels</topic><topic>Calcium channels (voltage-gated)</topic><topic>Calcium Channels - drug effects</topic><topic>Calcium Channels - metabolism</topic><topic>Calcium influx</topic><topic>Calcium ions</topic><topic>Calcium signalling</topic><topic>Channels</topic><topic>Electric potential</topic><topic>Glibenclamide</topic><topic>Glucagon</topic><topic>Glucagon-Like Peptide 1 - metabolism</topic><topic>Glucose</topic><topic>Hyperglycemia - metabolism</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Insulin</topic><topic>insulin secretagogue</topic><topic>Insulin secretion</topic><topic>Insulin Secretion - drug effects</topic><topic>Intestine</topic><topic>Islets of Langerhans - drug effects</topic><topic>Islets of Langerhans - metabolism</topic><topic>Lactase</topic><topic>Male</topic><topic>Overloading</topic><topic>Pancreas</topic><topic>Potassium</topic><topic>potassium channels</topic><topic>Potassium channels (voltage-gated)</topic><topic>Potassium Channels, Voltage-Gated - drug effects</topic><topic>Potassium Channels, Voltage-Gated - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Secretion</topic><topic>Signal transduction</topic><topic>Signal Transduction - drug effects</topic><topic>Sitagliptin Phosphate - pharmacology</topic><topic>Sodium</topic><topic>sodium channels</topic><topic>sulfonyl(thio)urea</topic><topic>Sulfonylurea Compounds - pharmacology</topic><topic>Transient receptor potential proteins</topic><topic>Urea</topic><topic>VDCC</topic><topic>Voltage-Gated Sodium Channels - drug effects</topic><topic>Voltage-Gated Sodium Channels - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sulis, Paola Miranda</creatorcontrib><creatorcontrib>Dambrós, Betina Fernanda</creatorcontrib><creatorcontrib>Mascarello, Alessandra</creatorcontrib><creatorcontrib>dos Santos, Adair Roberto Soares</creatorcontrib><creatorcontrib>Yunes, Rosendo Augusto</creatorcontrib><creatorcontrib>Nunes, Ricardo José</creatorcontrib><creatorcontrib>Frederico, Marisa Jádna Silva</creatorcontrib><creatorcontrib>Barreto Silva, Fátima Regina Mena</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sulis, Paola Miranda</au><au>Dambrós, Betina Fernanda</au><au>Mascarello, Alessandra</au><au>dos Santos, Adair Roberto Soares</au><au>Yunes, Rosendo Augusto</au><au>Nunes, Ricardo José</au><au>Frederico, Marisa Jádna Silva</au><au>Barreto Silva, Fátima Regina Mena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sulfonyl(thio)urea derivative induction of insulin secretion is mediated by potassium, calcium, and sodium channel signal transduction</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2019-07</date><risdate>2019</risdate><volume>234</volume><issue>7</issue><spage>10138</spage><epage>10147</epage><pages>10138-10147</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Aim To investigate the mechanism of action of sulfonyl(thio)urea derivative (SD) on glycemia and on insulin secretion in pancreatic islets. Methods Wistar rats were divided into hyperglycemic control group, rats received 4 g/kg body weight glucose plus sitagliptin 10 mg/kg (p.o.); hyperglycemic plus SD 10 mg/kg (p.o.); hyperglycemic plus SD plus sitagliptin. Blood was collected before glucose overloading (zero time), and at 15, 30, 60, and 180 min after glucose, from the afore mentioned groups for glycemia and glucagon‐like peptide 1 (GLP‐1) measurements and intestinal disaccharidases activity. Pancreatic islets were isolated for the calcium influx and insulin secretion in in vitro studies. Results SD reduced glycemia and increased GLP‐1 secretion, while inhibited sucrase and lactase activity. This SD (1.0 and 10.0 µM) stimulated calcium influx in a similar percentile to that of glibenclamide, and in a nonsynergic manner. In addition, the trigger effect of SD on calcium influx was through the K+‐ATP‐dependent channels, and partially by activating voltage‐dependent K + channels and voltage‐dependent calcium channels. Furthermore, SD‐stimulated Na + and Ca 2+ entry, induced by the transient receptor potential ankyrin 1 and by modulation of Na +/Ca 2+ exchange. The activation of these pathways by SD culminated in in vitro insulin secretion, reinforcing the critical role of K +‐ATP channels in the secretagogue effect of SD. Conclusions SD diminish glycemia by inducing GLP‐1 secretion and inhibiting disaccharidases. To our knowledge, this is the first report of an insulin secretagogue effect of SD that is mediated by potassium and calcium, as well as sodium, signal transduction. Sulfonyl(thio)urea derivative (SD) stimulates insulin secretion. Mechanism of action of SD on insulin secretion is mediated by potassium, calcium, and sodium.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30417369</pmid><doi>10.1002/jcp.27680</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1391-2354</orcidid></addata></record>
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subjects Animals
Ankyrins
ATP
Blood glucose
Body weight
Calcium channels
Calcium channels (voltage-gated)
Calcium Channels - drug effects
Calcium Channels - metabolism
Calcium influx
Calcium ions
Calcium signalling
Channels
Electric potential
Glibenclamide
Glucagon
Glucagon-Like Peptide 1 - metabolism
Glucose
Hyperglycemia - metabolism
Hypoglycemic Agents - pharmacology
Insulin
insulin secretagogue
Insulin secretion
Insulin Secretion - drug effects
Intestine
Islets of Langerhans - drug effects
Islets of Langerhans - metabolism
Lactase
Male
Overloading
Pancreas
Potassium
potassium channels
Potassium channels (voltage-gated)
Potassium Channels, Voltage-Gated - drug effects
Potassium Channels, Voltage-Gated - metabolism
Rats
Rats, Wistar
Rodents
Secretion
Signal transduction
Signal Transduction - drug effects
Sitagliptin Phosphate - pharmacology
Sodium
sodium channels
sulfonyl(thio)urea
Sulfonylurea Compounds - pharmacology
Transient receptor potential proteins
Urea
VDCC
Voltage-Gated Sodium Channels - drug effects
Voltage-Gated Sodium Channels - metabolism
title Sulfonyl(thio)urea derivative induction of insulin secretion is mediated by potassium, calcium, and sodium channel signal transduction
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