MicroRNA-323a-3p Promotes Pressure Overload-Induced Cardiac Fibrosis by Targeting TIMP3

Background/Aims: Cardiac fibrosis is a major cause of diverse cardiovascular diseases. MicroRNAs have recently been proven a novel class of regulators of cardiac fibrosis. In this study, we sought to investigate the role of miR-323a-3p and its mechanisms in regulating cardiac fibrosis. Methods: The...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cellular physiology and biochemistry 2018-01, Vol.50 (6), p.2176-2187
Hauptverfasser:	Zhang, JingChao , Lang, Yan, Guo, LongHui, Pei, Yu, Hao, Shuang, Liang, ZhenXing, Su, Gang, Shu, LiLiang, Liu, Hai, Huang, Chen, Xu, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Acute coronary syndromes Angiotensin II - pharmacology Animals Antagomirs - metabolism Ataxia Biochemistry Cardiac fibrosis Cardiac function Cardiology Cardiomyopathy Cells, Cultured Collagen Type I - genetics Collagen Type I - metabolism Coronary vessels Extracellular matrix Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Fibrosis Gene expression Heart attacks Heart failure Male Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Mice Mice, Inbred C57BL MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism miR-323-3p Myocardium - metabolism Myocardium - pathology Original Paper Physiology Rats Rats, Sprague-Dawley RNA Interference RNA, Small Interfering - metabolism TAC TGFβ TIMP3 Tissue Inhibitor of Metalloproteinase-3 - antagonists & inhibitors Tissue Inhibitor of Metalloproteinase-3 - genetics Tissue Inhibitor of Metalloproteinase-3 - metabolism Transforming Growth Factor beta1 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!