Impact of water exposure on skin barrier permeability and ultrastructure
Background Skin occlusion caused by the use of diapers or sanitary napkins often results in irritant contact dermatitis. Furthermore, prolonged occlusion and exposure to body fluids are known to increase skin hydration and permeability, thus leading to irritant contact dermatitis. Objective To inves...
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| Veröffentlicht in: | Contact dermatitis 2019-04, Vol.80 (4), p.228-233 |
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| container_title | Contact dermatitis |
| container_volume | 80 |
| creator | Ogawa‐Fuse, Chie Morisaki, Naoko Shima, Kyoko Hotta, Mitsuyuki Sugata, Keiichi Ichihashi, Toshiki Oguri, Masashi Yoshida, Osamu Fujimura, Tsutomu |
| description | Background
Skin occlusion caused by the use of diapers or sanitary napkins often results in irritant contact dermatitis. Furthermore, prolonged occlusion and exposure to body fluids are known to increase skin hydration and permeability, thus leading to irritant contact dermatitis.
Objective
To investigate the effects of water exposure on the skin and its barrier functions, in order to obtain more insights into the mechanisms of irritant contact dermatitis.
Methods
Water patches were applied to the volar forearm skin of 10 human subjects for 3 hours. Permeability of the stratum corneum (SC) was examined with methyl nicotinate (MN). Alterations in the hydration and ultrastructure of the SC were measured with Raman spectroscopy and multiphoton microscopy, respectively.
Results
Water profiles found with Raman spectroscopy showed notable increases in water content throughout the SC and skin surface. Multiphoton microscopy showed morphological changes in the intercellular space of the SC. Emerged pools seemed to contribute to increased MN absorption.
Conclusion
Excessive skin hydration leading to changes in the SC ultrastructure might result in increased skin permeability to skin irritants and allergens. |
| doi_str_mv | 10.1111/cod.13174 |
| format | Article |
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Skin occlusion caused by the use of diapers or sanitary napkins often results in irritant contact dermatitis. Furthermore, prolonged occlusion and exposure to body fluids are known to increase skin hydration and permeability, thus leading to irritant contact dermatitis.
Objective
To investigate the effects of water exposure on the skin and its barrier functions, in order to obtain more insights into the mechanisms of irritant contact dermatitis.
Methods
Water patches were applied to the volar forearm skin of 10 human subjects for 3 hours. Permeability of the stratum corneum (SC) was examined with methyl nicotinate (MN). Alterations in the hydration and ultrastructure of the SC were measured with Raman spectroscopy and multiphoton microscopy, respectively.
Results
Water profiles found with Raman spectroscopy showed notable increases in water content throughout the SC and skin surface. Multiphoton microscopy showed morphological changes in the intercellular space of the SC. Emerged pools seemed to contribute to increased MN absorption.
Conclusion
Excessive skin hydration leading to changes in the SC ultrastructure might result in increased skin permeability to skin irritants and allergens.</description><identifier>ISSN: 0105-1873</identifier><identifier>EISSN: 1600-0536</identifier><identifier>DOI: 10.1111/cod.13174</identifier><identifier>PMID: 30417381</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Allergens ; Body fluids ; Contact dermatitis ; Dermatitis ; Eczema ; Forearm ; Hydration ; irritant contact dermatitis ; Menstrual products ; Microscopy ; non‐invasive measurement ; Occlusion ; Permeability ; Raman spectroscopy ; Skin ; skin barrier ; Spectrum analysis ; Stratum corneum ; Ultrastructure ; Water content</subject><ispartof>Contact dermatitis, 2019-04, Vol.80 (4), p.228-233</ispartof><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-d2c59e5419249dafc8461be7ebaad07305ec6def9309ff7113b359b43505f2113</citedby><cites>FETCH-LOGICAL-c3534-d2c59e5419249dafc8461be7ebaad07305ec6def9309ff7113b359b43505f2113</cites><orcidid>0000-0002-8495-2580</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcod.13174$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcod.13174$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30417381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogawa‐Fuse, Chie</creatorcontrib><creatorcontrib>Morisaki, Naoko</creatorcontrib><creatorcontrib>Shima, Kyoko</creatorcontrib><creatorcontrib>Hotta, Mitsuyuki</creatorcontrib><creatorcontrib>Sugata, Keiichi</creatorcontrib><creatorcontrib>Ichihashi, Toshiki</creatorcontrib><creatorcontrib>Oguri, Masashi</creatorcontrib><creatorcontrib>Yoshida, Osamu</creatorcontrib><creatorcontrib>Fujimura, Tsutomu</creatorcontrib><title>Impact of water exposure on skin barrier permeability and ultrastructure</title><title>Contact dermatitis</title><addtitle>Contact Dermatitis</addtitle><description>Background
Skin occlusion caused by the use of diapers or sanitary napkins often results in irritant contact dermatitis. Furthermore, prolonged occlusion and exposure to body fluids are known to increase skin hydration and permeability, thus leading to irritant contact dermatitis.
Objective
To investigate the effects of water exposure on the skin and its barrier functions, in order to obtain more insights into the mechanisms of irritant contact dermatitis.
Methods
Water patches were applied to the volar forearm skin of 10 human subjects for 3 hours. Permeability of the stratum corneum (SC) was examined with methyl nicotinate (MN). Alterations in the hydration and ultrastructure of the SC were measured with Raman spectroscopy and multiphoton microscopy, respectively.
Results
Water profiles found with Raman spectroscopy showed notable increases in water content throughout the SC and skin surface. Multiphoton microscopy showed morphological changes in the intercellular space of the SC. Emerged pools seemed to contribute to increased MN absorption.
Conclusion
Excessive skin hydration leading to changes in the SC ultrastructure might result in increased skin permeability to skin irritants and allergens.</description><subject>Allergens</subject><subject>Body fluids</subject><subject>Contact dermatitis</subject><subject>Dermatitis</subject><subject>Eczema</subject><subject>Forearm</subject><subject>Hydration</subject><subject>irritant contact dermatitis</subject><subject>Menstrual products</subject><subject>Microscopy</subject><subject>non‐invasive measurement</subject><subject>Occlusion</subject><subject>Permeability</subject><subject>Raman spectroscopy</subject><subject>Skin</subject><subject>skin barrier</subject><subject>Spectrum analysis</subject><subject>Stratum corneum</subject><subject>Ultrastructure</subject><subject>Water content</subject><issn>0105-1873</issn><issn>1600-0536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp10MtKw0AUBuBBFFurC19ABtzoIu2cueSylHppodCNrsNkcgKpuTmToH17R1NdCM7mMJyPn8NPyCWwOfi3MG0-BwGRPCJTCBkLmBLhMZkyYCqAOBITcubcjjEIJY9PyUQwCZGIYUpW67rTpqdtQd91j5biR9e6wSJtG-pey4Zm2trSLzq0NeqsrMp-T3WT06HqrXa9HUzv_Tk5KXTl8OIwZ-Tl8eF5uQo226f18m4TGKGEDHJuVIJKQsJlkuvCxDKEDCPMtM5ZJJhCE-ZYJIIlRREBiEyoJJNCMVVw_52RmzG3s-3bgK5P69IZrCrdYDu4lIPgXHEZh55e_6G7drCNv86rRHCmYuBe3Y7K2NY5i0Xa2bLWdp8CS7_qTX296Xe93l4dEoesxvxX_vTpwWIE72WF-_-T0uX2foz8BDX0guo</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Ogawa‐Fuse, Chie</creator><creator>Morisaki, Naoko</creator><creator>Shima, Kyoko</creator><creator>Hotta, Mitsuyuki</creator><creator>Sugata, Keiichi</creator><creator>Ichihashi, Toshiki</creator><creator>Oguri, Masashi</creator><creator>Yoshida, Osamu</creator><creator>Fujimura, Tsutomu</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8495-2580</orcidid></search><sort><creationdate>201904</creationdate><title>Impact of water exposure on skin barrier permeability and ultrastructure</title><author>Ogawa‐Fuse, Chie ; Morisaki, Naoko ; Shima, Kyoko ; Hotta, Mitsuyuki ; Sugata, Keiichi ; Ichihashi, Toshiki ; Oguri, Masashi ; Yoshida, Osamu ; Fujimura, Tsutomu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-d2c59e5419249dafc8461be7ebaad07305ec6def9309ff7113b359b43505f2113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Allergens</topic><topic>Body fluids</topic><topic>Contact dermatitis</topic><topic>Dermatitis</topic><topic>Eczema</topic><topic>Forearm</topic><topic>Hydration</topic><topic>irritant contact dermatitis</topic><topic>Menstrual products</topic><topic>Microscopy</topic><topic>non‐invasive measurement</topic><topic>Occlusion</topic><topic>Permeability</topic><topic>Raman spectroscopy</topic><topic>Skin</topic><topic>skin barrier</topic><topic>Spectrum analysis</topic><topic>Stratum corneum</topic><topic>Ultrastructure</topic><topic>Water content</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogawa‐Fuse, Chie</creatorcontrib><creatorcontrib>Morisaki, Naoko</creatorcontrib><creatorcontrib>Shima, Kyoko</creatorcontrib><creatorcontrib>Hotta, Mitsuyuki</creatorcontrib><creatorcontrib>Sugata, Keiichi</creatorcontrib><creatorcontrib>Ichihashi, Toshiki</creatorcontrib><creatorcontrib>Oguri, Masashi</creatorcontrib><creatorcontrib>Yoshida, Osamu</creatorcontrib><creatorcontrib>Fujimura, Tsutomu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Contact dermatitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogawa‐Fuse, Chie</au><au>Morisaki, Naoko</au><au>Shima, Kyoko</au><au>Hotta, Mitsuyuki</au><au>Sugata, Keiichi</au><au>Ichihashi, Toshiki</au><au>Oguri, Masashi</au><au>Yoshida, Osamu</au><au>Fujimura, Tsutomu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of water exposure on skin barrier permeability and ultrastructure</atitle><jtitle>Contact dermatitis</jtitle><addtitle>Contact Dermatitis</addtitle><date>2019-04</date><risdate>2019</risdate><volume>80</volume><issue>4</issue><spage>228</spage><epage>233</epage><pages>228-233</pages><issn>0105-1873</issn><eissn>1600-0536</eissn><abstract>Background
Skin occlusion caused by the use of diapers or sanitary napkins often results in irritant contact dermatitis. Furthermore, prolonged occlusion and exposure to body fluids are known to increase skin hydration and permeability, thus leading to irritant contact dermatitis.
Objective
To investigate the effects of water exposure on the skin and its barrier functions, in order to obtain more insights into the mechanisms of irritant contact dermatitis.
Methods
Water patches were applied to the volar forearm skin of 10 human subjects for 3 hours. Permeability of the stratum corneum (SC) was examined with methyl nicotinate (MN). Alterations in the hydration and ultrastructure of the SC were measured with Raman spectroscopy and multiphoton microscopy, respectively.
Results
Water profiles found with Raman spectroscopy showed notable increases in water content throughout the SC and skin surface. Multiphoton microscopy showed morphological changes in the intercellular space of the SC. Emerged pools seemed to contribute to increased MN absorption.
Conclusion
Excessive skin hydration leading to changes in the SC ultrastructure might result in increased skin permeability to skin irritants and allergens.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>30417381</pmid><doi>10.1111/cod.13174</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8495-2580</orcidid></addata></record> |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Allergens Body fluids Contact dermatitis Dermatitis Eczema Forearm Hydration irritant contact dermatitis Menstrual products Microscopy non‐invasive measurement Occlusion Permeability Raman spectroscopy Skin skin barrier Spectrum analysis Stratum corneum Ultrastructure Water content |
| title | Impact of water exposure on skin barrier permeability and ultrastructure |
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