Development of a Highly Selective Two-Photon Probe for Methylglyoxal and its Applications in Living Cells, Tissues, and Zebrafish
Methylglyoxal (MGO) is one of the most important active carbonyl compounds in living organisms. It is a metabolic by product of glycolysis. MGO participates in glycosylation of proteins and nucleic acids to trigger carbonyl stress, inducing pathological status and even exacerbateing the development...
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| Veröffentlicht in: | Journal of fluorescence 2019-01, Vol.29 (1), p.155-163 |
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| creator | Gao, Shiying Tang, Yonghe Lin, Weiying |
| description | Methylglyoxal (MGO) is one of the most important active carbonyl compounds in living organisms. It is a metabolic by product of glycolysis. MGO participates in glycosylation of proteins and nucleic acids to trigger carbonyl stress, inducing pathological status and even exacerbateing the development of chronic degenerative diseases. In order to study the diseases caused by MGO, it is meaningful for us to develop methods that could efficiently detect MGO. In our work, a new two-photon fluorescent turn-on probe which named
NP
has been designed which was made up of naphthalimides dye as the two-photon fluorescent platform and the
o
-phenylenediamine as recognition site. When reacted with MGO,
NP
showed excellent sensitivity and selectivity. Based on the two-photon fluorescence imaging technology,
NP
has firstly successful application in living cells, tissues and zebrafish to detecting MGO. |
| doi_str_mv | 10.1007/s10895-018-2323-3 |
| format | Article |
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NP
has been designed which was made up of naphthalimides dye as the two-photon fluorescent platform and the
o
-phenylenediamine as recognition site. When reacted with MGO,
NP
showed excellent sensitivity and selectivity. Based on the two-photon fluorescence imaging technology,
NP
has firstly successful application in living cells, tissues and zebrafish to detecting MGO.</description><identifier>ISSN: 1053-0509</identifier><identifier>EISSN: 1573-4994</identifier><identifier>DOI: 10.1007/s10895-018-2323-3</identifier><identifier>PMID: 30417249</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analytical Chemistry ; Animals ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biomedicine ; Biophysics ; Biotechnology ; Carbonyl compounds ; Carbonyls ; Cells (biology) ; Density Functional Theory ; Fluorescence ; Fluorescent Dyes - chemical synthesis ; Fluorescent Dyes - chemistry ; Glycolysis ; HeLa Cells ; Humans ; Molecular Structure ; Nucleic acids ; Optical Imaging ; Original Article ; Phenylenediamine ; Photons ; Proteins ; Pyruvaldehyde - chemical synthesis ; Pyruvaldehyde - chemistry ; Selectivity ; Zebrafish</subject><ispartof>Journal of fluorescence, 2019-01, Vol.29 (1), p.155-163</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Copyright Springer Nature B.V. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-d7935d213a85e3d71baf5ef8e2d2a7d9c223423b1fe9d8c7bbaa970a48b5d9163</citedby><cites>FETCH-LOGICAL-c372t-d7935d213a85e3d71baf5ef8e2d2a7d9c223423b1fe9d8c7bbaa970a48b5d9163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10895-018-2323-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10895-018-2323-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30417249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Shiying</creatorcontrib><creatorcontrib>Tang, Yonghe</creatorcontrib><creatorcontrib>Lin, Weiying</creatorcontrib><title>Development of a Highly Selective Two-Photon Probe for Methylglyoxal and its Applications in Living Cells, Tissues, and Zebrafish</title><title>Journal of fluorescence</title><addtitle>J Fluoresc</addtitle><addtitle>J Fluoresc</addtitle><description>Methylglyoxal (MGO) is one of the most important active carbonyl compounds in living organisms. It is a metabolic by product of glycolysis. MGO participates in glycosylation of proteins and nucleic acids to trigger carbonyl stress, inducing pathological status and even exacerbateing the development of chronic degenerative diseases. In order to study the diseases caused by MGO, it is meaningful for us to develop methods that could efficiently detect MGO. In our work, a new two-photon fluorescent turn-on probe which named
NP
has been designed which was made up of naphthalimides dye as the two-photon fluorescent platform and the
o
-phenylenediamine as recognition site. When reacted with MGO,
NP
showed excellent sensitivity and selectivity. Based on the two-photon fluorescence imaging technology,
NP
has firstly successful application in living cells, tissues and zebrafish to detecting MGO.</description><subject>Analytical Chemistry</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Biotechnology</subject><subject>Carbonyl compounds</subject><subject>Carbonyls</subject><subject>Cells (biology)</subject><subject>Density Functional Theory</subject><subject>Fluorescence</subject><subject>Fluorescent Dyes - chemical synthesis</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Glycolysis</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Molecular Structure</subject><subject>Nucleic acids</subject><subject>Optical Imaging</subject><subject>Original Article</subject><subject>Phenylenediamine</subject><subject>Photons</subject><subject>Proteins</subject><subject>Pyruvaldehyde - chemical synthesis</subject><subject>Pyruvaldehyde - chemistry</subject><subject>Selectivity</subject><subject>Zebrafish</subject><issn>1053-0509</issn><issn>1573-4994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU2LUzEUhoMozjj6A9xIwI0Lo_m4Mcly6KgjVBywbtyE3Jtz2wxpck1uq136z03pqCC4yoE8581LHoSeMvqKUapeV0a1kYQyTbjggoh76JxJJUhnTHe_zVQKQiU1Z-hRrbeUUqM7_RCdCdoxxTtzjn5ewR5inraQZpxH7PB1WG_iAX-GCMMc9oBX3zO52eQ5J3xTcg94zAV_hHlziOt4yD9cxC55HOaKL6cphsHNIaeKQ8LLsA9pjRcQY32JV6HWHbThiH-Fvrgx1M1j9GB0scKTu_MCfXn3drW4JstP7z8sLpdkEIrPxCsjpOdMOC1BeMV6N0oYNXDPnfJm4Fx0XPRsBOP1oPreOaOo63QvvWFvxAV6ccqdSv7Wasx2G-rQmrkEeVdti-btSxRjDX3-D3qbdyW1do0yUijWGd0odqKGkmstMNqphK0rB8uoPfqxJz-2-bFHP1a0nWd3ybt-C_7Pxm8hDeAnoLartIby9-n_p_4CIQCbiw</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Gao, Shiying</creator><creator>Tang, Yonghe</creator><creator>Lin, Weiying</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190101</creationdate><title>Development of a Highly Selective Two-Photon Probe for Methylglyoxal and its Applications in Living Cells, Tissues, and Zebrafish</title><author>Gao, Shiying ; Tang, Yonghe ; Lin, Weiying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-d7935d213a85e3d71baf5ef8e2d2a7d9c223423b1fe9d8c7bbaa970a48b5d9163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Analytical Chemistry</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biological and Medical Physics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biophysics</topic><topic>Biotechnology</topic><topic>Carbonyl compounds</topic><topic>Carbonyls</topic><topic>Cells (biology)</topic><topic>Density Functional Theory</topic><topic>Fluorescence</topic><topic>Fluorescent Dyes - chemical synthesis</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Glycolysis</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Molecular Structure</topic><topic>Nucleic acids</topic><topic>Optical Imaging</topic><topic>Original Article</topic><topic>Phenylenediamine</topic><topic>Photons</topic><topic>Proteins</topic><topic>Pyruvaldehyde - chemical synthesis</topic><topic>Pyruvaldehyde - chemistry</topic><topic>Selectivity</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Shiying</creatorcontrib><creatorcontrib>Tang, Yonghe</creatorcontrib><creatorcontrib>Lin, Weiying</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of fluorescence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Shiying</au><au>Tang, Yonghe</au><au>Lin, Weiying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of a Highly Selective Two-Photon Probe for Methylglyoxal and its Applications in Living Cells, Tissues, and Zebrafish</atitle><jtitle>Journal of fluorescence</jtitle><stitle>J Fluoresc</stitle><addtitle>J Fluoresc</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>29</volume><issue>1</issue><spage>155</spage><epage>163</epage><pages>155-163</pages><issn>1053-0509</issn><eissn>1573-4994</eissn><abstract>Methylglyoxal (MGO) is one of the most important active carbonyl compounds in living organisms. It is a metabolic by product of glycolysis. MGO participates in glycosylation of proteins and nucleic acids to trigger carbonyl stress, inducing pathological status and even exacerbateing the development of chronic degenerative diseases. In order to study the diseases caused by MGO, it is meaningful for us to develop methods that could efficiently detect MGO. In our work, a new two-photon fluorescent turn-on probe which named
NP
has been designed which was made up of naphthalimides dye as the two-photon fluorescent platform and the
o
-phenylenediamine as recognition site. When reacted with MGO,
NP
showed excellent sensitivity and selectivity. Based on the two-photon fluorescence imaging technology,
NP
has firstly successful application in living cells, tissues and zebrafish to detecting MGO.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30417249</pmid><doi>10.1007/s10895-018-2323-3</doi><tpages>9</tpages></addata></record> |
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| subjects | Analytical Chemistry Animals Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedicine Biophysics Biotechnology Carbonyl compounds Carbonyls Cells (biology) Density Functional Theory Fluorescence Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Glycolysis HeLa Cells Humans Molecular Structure Nucleic acids Optical Imaging Original Article Phenylenediamine Photons Proteins Pyruvaldehyde - chemical synthesis Pyruvaldehyde - chemistry Selectivity Zebrafish |
| title | Development of a Highly Selective Two-Photon Probe for Methylglyoxal and its Applications in Living Cells, Tissues, and Zebrafish |
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