Primary tumor location in stage III colon cancer has prognostic impact on subsequent liver metastasis
Background and Objectives We aim to investigate whether a difference exists between right‐sided and left‐sided colon cancer at the same disease stage and subsequent liver metastasis and identify whether tumor location can independently influence survival. Methods Right‐sided colon cancer was defined...
Gespeichert in:
| Veröffentlicht in: | Journal of surgical oncology 2018-12, Vol.118 (8), p.1301-1310 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1310 |
|---|---|
| container_issue | 8 |
| container_start_page | 1301 |
| container_title | Journal of surgical oncology |
| container_volume | 118 |
| creator | Liao, Chun‐Kai Chiang, Jy‐Ming Tsai, Wen‐Sy You, Jeng‐Fu Hsieh, Pao‐Shiu Hung, Hsin‐Yuan Chen, Hong‐Hwa Tang, Rei‐Ping Chen, Jinn‐Shiun Yeh, Chien‐Yuh |
| description | Background and Objectives
We aim to investigate whether a difference exists between right‐sided and left‐sided colon cancer at the same disease stage and subsequent liver metastasis and identify whether tumor location can independently influence survival.
Methods
Right‐sided colon cancer was defined as malignancy arising from the cecum to the transverse colon; left‐sided colon cancer was defined as malignancy arising from the splenic flexure to the sigmoid colon. Clinicopathological features and survival data were collected for analysis.
Results
Overall, 1442 patients were included for analysis. The median follow‐up time was 58.2 months. Patients with left‐sided colon cancer had better 5‐year overall survival (75.2% vs 61.7%, P = 0.005), 5‐year cancer‐specific survival (81.6% vs 73.4%,
P = 0.001), and 5‐year recurrence‐free survival (70.9% vs 66.5%,
P = 0.033) compared with patients having right‐sided colon cancer. After the presentation of subsequent liver metastasis, patients with primary left‐sided colon cancer had better 3‐year cancer‐specific survival (
P |
| doi_str_mv | 10.1002/jso.25270 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2132234059</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2132234059</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3530-eefb6bbabe59a246d0f5ff1c9e5227e0365f670aaf13e83f2a3c719e7f1acfd63</originalsourceid><addsrcrecordid>eNp1kEtLxDAURoMozvhY-Ack4EYXHW-Spp0sZfAxIiio65JmbsYMbTM2reK_N9rRheAqkHs4fBxCjhhMGAA_XwU_4ZLnsEXGDFSWKFDTbTKON56kuYIR2QthBQBKZekuGQlIYcqmYkzwoXW1bj9o19e-pZU3unO-oa6hodNLpPP5nBpfxS-jG4MtfdGBrlu_bHzonKGuXmvT0XgPfRnwtcemo5V7i2SNnY6S4MIB2bG6Cni4effJ89Xl0-wmubu_ns8u7hIjpIAE0ZZZWeoSpdI8zRZgpbXMKJSc5wgikzbLQWvLBE6F5VqYnCnMLdPGLjKxT04HbxwYl4SuqF0wWFW6Qd-HgjPBuUhBqoie_EFXvm-buO6LymQuWC4jdTZQpvUhtGiL9dCrYFB8tS9i--K7fWSPN8a-rHHxS_7EjsD5ALy7Cj_-NxW3j_eD8hOVSY8a</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2136573175</pqid></control><display><type>article</type><title>Primary tumor location in stage III colon cancer has prognostic impact on subsequent liver metastasis</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Liao, Chun‐Kai ; Chiang, Jy‐Ming ; Tsai, Wen‐Sy ; You, Jeng‐Fu ; Hsieh, Pao‐Shiu ; Hung, Hsin‐Yuan ; Chen, Hong‐Hwa ; Tang, Rei‐Ping ; Chen, Jinn‐Shiun ; Yeh, Chien‐Yuh</creator><creatorcontrib>Liao, Chun‐Kai ; Chiang, Jy‐Ming ; Tsai, Wen‐Sy ; You, Jeng‐Fu ; Hsieh, Pao‐Shiu ; Hung, Hsin‐Yuan ; Chen, Hong‐Hwa ; Tang, Rei‐Ping ; Chen, Jinn‐Shiun ; Yeh, Chien‐Yuh</creatorcontrib><description>Background and Objectives
We aim to investigate whether a difference exists between right‐sided and left‐sided colon cancer at the same disease stage and subsequent liver metastasis and identify whether tumor location can independently influence survival.
Methods
Right‐sided colon cancer was defined as malignancy arising from the cecum to the transverse colon; left‐sided colon cancer was defined as malignancy arising from the splenic flexure to the sigmoid colon. Clinicopathological features and survival data were collected for analysis.
Results
Overall, 1442 patients were included for analysis. The median follow‐up time was 58.2 months. Patients with left‐sided colon cancer had better 5‐year overall survival (75.2% vs 61.7%, P = 0.005), 5‐year cancer‐specific survival (81.6% vs 73.4%,
P = 0.001), and 5‐year recurrence‐free survival (70.9% vs 66.5%,
P = 0.033) compared with patients having right‐sided colon cancer. After the presentation of subsequent liver metastasis, patients with primary left‐sided colon cancer had better 3‐year cancer‐specific survival (
P < 0.001). In the multivariate analysis, cancer location was an independent prognostic factor for cancer‐specific survival (right vs left, HR: 1.276, 95% CI: 1.002‐1.625).
Conclusions
The primary tumor location can serve as a prognostic factor for treatment outcomes either in primary stage III colon cancer or subsequent liver metastasis.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.25270</identifier><identifier>PMID: 30408183</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Aged ; Cancer surgery ; colon cancer ; Colonic Neoplasms - mortality ; Colonic Neoplasms - pathology ; Colonic Neoplasms - surgery ; Colorectal cancer ; Disease-Free Survival ; Female ; Humans ; left ; Liver ; liver metastasis ; Liver Neoplasms - mortality ; Liver Neoplasms - secondary ; location ; Male ; Metastasis ; Middle Aged ; Neoplasm Staging ; outcome ; Prognosis ; Registries ; right ; Taiwan - epidemiology</subject><ispartof>Journal of surgical oncology, 2018-12, Vol.118 (8), p.1301-1310</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3530-eefb6bbabe59a246d0f5ff1c9e5227e0365f670aaf13e83f2a3c719e7f1acfd63</citedby><cites>FETCH-LOGICAL-c3530-eefb6bbabe59a246d0f5ff1c9e5227e0365f670aaf13e83f2a3c719e7f1acfd63</cites><orcidid>0000-0002-7497-4444</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.25270$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.25270$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30408183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liao, Chun‐Kai</creatorcontrib><creatorcontrib>Chiang, Jy‐Ming</creatorcontrib><creatorcontrib>Tsai, Wen‐Sy</creatorcontrib><creatorcontrib>You, Jeng‐Fu</creatorcontrib><creatorcontrib>Hsieh, Pao‐Shiu</creatorcontrib><creatorcontrib>Hung, Hsin‐Yuan</creatorcontrib><creatorcontrib>Chen, Hong‐Hwa</creatorcontrib><creatorcontrib>Tang, Rei‐Ping</creatorcontrib><creatorcontrib>Chen, Jinn‐Shiun</creatorcontrib><creatorcontrib>Yeh, Chien‐Yuh</creatorcontrib><title>Primary tumor location in stage III colon cancer has prognostic impact on subsequent liver metastasis</title><title>Journal of surgical oncology</title><addtitle>J Surg Oncol</addtitle><description>Background and Objectives
We aim to investigate whether a difference exists between right‐sided and left‐sided colon cancer at the same disease stage and subsequent liver metastasis and identify whether tumor location can independently influence survival.
Methods
Right‐sided colon cancer was defined as malignancy arising from the cecum to the transverse colon; left‐sided colon cancer was defined as malignancy arising from the splenic flexure to the sigmoid colon. Clinicopathological features and survival data were collected for analysis.
Results
Overall, 1442 patients were included for analysis. The median follow‐up time was 58.2 months. Patients with left‐sided colon cancer had better 5‐year overall survival (75.2% vs 61.7%, P = 0.005), 5‐year cancer‐specific survival (81.6% vs 73.4%,
P = 0.001), and 5‐year recurrence‐free survival (70.9% vs 66.5%,
P = 0.033) compared with patients having right‐sided colon cancer. After the presentation of subsequent liver metastasis, patients with primary left‐sided colon cancer had better 3‐year cancer‐specific survival (
P < 0.001). In the multivariate analysis, cancer location was an independent prognostic factor for cancer‐specific survival (right vs left, HR: 1.276, 95% CI: 1.002‐1.625).
Conclusions
The primary tumor location can serve as a prognostic factor for treatment outcomes either in primary stage III colon cancer or subsequent liver metastasis.</description><subject>Aged</subject><subject>Cancer surgery</subject><subject>colon cancer</subject><subject>Colonic Neoplasms - mortality</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colonic Neoplasms - surgery</subject><subject>Colorectal cancer</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>left</subject><subject>Liver</subject><subject>liver metastasis</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - secondary</subject><subject>location</subject><subject>Male</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>outcome</subject><subject>Prognosis</subject><subject>Registries</subject><subject>right</subject><subject>Taiwan - epidemiology</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLxDAURoMozvhY-Ack4EYXHW-Spp0sZfAxIiio65JmbsYMbTM2reK_N9rRheAqkHs4fBxCjhhMGAA_XwU_4ZLnsEXGDFSWKFDTbTKON56kuYIR2QthBQBKZekuGQlIYcqmYkzwoXW1bj9o19e-pZU3unO-oa6hodNLpPP5nBpfxS-jG4MtfdGBrlu_bHzonKGuXmvT0XgPfRnwtcemo5V7i2SNnY6S4MIB2bG6Cni4effJ89Xl0-wmubu_ns8u7hIjpIAE0ZZZWeoSpdI8zRZgpbXMKJSc5wgikzbLQWvLBE6F5VqYnCnMLdPGLjKxT04HbxwYl4SuqF0wWFW6Qd-HgjPBuUhBqoie_EFXvm-buO6LymQuWC4jdTZQpvUhtGiL9dCrYFB8tS9i--K7fWSPN8a-rHHxS_7EjsD5ALy7Cj_-NxW3j_eD8hOVSY8a</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Liao, Chun‐Kai</creator><creator>Chiang, Jy‐Ming</creator><creator>Tsai, Wen‐Sy</creator><creator>You, Jeng‐Fu</creator><creator>Hsieh, Pao‐Shiu</creator><creator>Hung, Hsin‐Yuan</creator><creator>Chen, Hong‐Hwa</creator><creator>Tang, Rei‐Ping</creator><creator>Chen, Jinn‐Shiun</creator><creator>Yeh, Chien‐Yuh</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7497-4444</orcidid></search><sort><creationdate>20181201</creationdate><title>Primary tumor location in stage III colon cancer has prognostic impact on subsequent liver metastasis</title><author>Liao, Chun‐Kai ; Chiang, Jy‐Ming ; Tsai, Wen‐Sy ; You, Jeng‐Fu ; Hsieh, Pao‐Shiu ; Hung, Hsin‐Yuan ; Chen, Hong‐Hwa ; Tang, Rei‐Ping ; Chen, Jinn‐Shiun ; Yeh, Chien‐Yuh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3530-eefb6bbabe59a246d0f5ff1c9e5227e0365f670aaf13e83f2a3c719e7f1acfd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Cancer surgery</topic><topic>colon cancer</topic><topic>Colonic Neoplasms - mortality</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colonic Neoplasms - surgery</topic><topic>Colorectal cancer</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>left</topic><topic>Liver</topic><topic>liver metastasis</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - secondary</topic><topic>location</topic><topic>Male</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>outcome</topic><topic>Prognosis</topic><topic>Registries</topic><topic>right</topic><topic>Taiwan - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liao, Chun‐Kai</creatorcontrib><creatorcontrib>Chiang, Jy‐Ming</creatorcontrib><creatorcontrib>Tsai, Wen‐Sy</creatorcontrib><creatorcontrib>You, Jeng‐Fu</creatorcontrib><creatorcontrib>Hsieh, Pao‐Shiu</creatorcontrib><creatorcontrib>Hung, Hsin‐Yuan</creatorcontrib><creatorcontrib>Chen, Hong‐Hwa</creatorcontrib><creatorcontrib>Tang, Rei‐Ping</creatorcontrib><creatorcontrib>Chen, Jinn‐Shiun</creatorcontrib><creatorcontrib>Yeh, Chien‐Yuh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liao, Chun‐Kai</au><au>Chiang, Jy‐Ming</au><au>Tsai, Wen‐Sy</au><au>You, Jeng‐Fu</au><au>Hsieh, Pao‐Shiu</au><au>Hung, Hsin‐Yuan</au><au>Chen, Hong‐Hwa</au><au>Tang, Rei‐Ping</au><au>Chen, Jinn‐Shiun</au><au>Yeh, Chien‐Yuh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary tumor location in stage III colon cancer has prognostic impact on subsequent liver metastasis</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J Surg Oncol</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>118</volume><issue>8</issue><spage>1301</spage><epage>1310</epage><pages>1301-1310</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background and Objectives
We aim to investigate whether a difference exists between right‐sided and left‐sided colon cancer at the same disease stage and subsequent liver metastasis and identify whether tumor location can independently influence survival.
Methods
Right‐sided colon cancer was defined as malignancy arising from the cecum to the transverse colon; left‐sided colon cancer was defined as malignancy arising from the splenic flexure to the sigmoid colon. Clinicopathological features and survival data were collected for analysis.
Results
Overall, 1442 patients were included for analysis. The median follow‐up time was 58.2 months. Patients with left‐sided colon cancer had better 5‐year overall survival (75.2% vs 61.7%, P = 0.005), 5‐year cancer‐specific survival (81.6% vs 73.4%,
P = 0.001), and 5‐year recurrence‐free survival (70.9% vs 66.5%,
P = 0.033) compared with patients having right‐sided colon cancer. After the presentation of subsequent liver metastasis, patients with primary left‐sided colon cancer had better 3‐year cancer‐specific survival (
P < 0.001). In the multivariate analysis, cancer location was an independent prognostic factor for cancer‐specific survival (right vs left, HR: 1.276, 95% CI: 1.002‐1.625).
Conclusions
The primary tumor location can serve as a prognostic factor for treatment outcomes either in primary stage III colon cancer or subsequent liver metastasis.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30408183</pmid><doi>10.1002/jso.25270</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7497-4444</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-4790 |
| ispartof | Journal of surgical oncology, 2018-12, Vol.118 (8), p.1301-1310 |
| issn | 0022-4790 1096-9098 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2132234059 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Aged Cancer surgery colon cancer Colonic Neoplasms - mortality Colonic Neoplasms - pathology Colonic Neoplasms - surgery Colorectal cancer Disease-Free Survival Female Humans left Liver liver metastasis Liver Neoplasms - mortality Liver Neoplasms - secondary location Male Metastasis Middle Aged Neoplasm Staging outcome Prognosis Registries right Taiwan - epidemiology |
| title | Primary tumor location in stage III colon cancer has prognostic impact on subsequent liver metastasis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T17%3A48%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Primary%20tumor%20location%20in%20stage%20III%20colon%20cancer%20has%20prognostic%20impact%20on%20subsequent%20liver%20metastasis&rft.jtitle=Journal%20of%20surgical%20oncology&rft.au=Liao,%20Chun%E2%80%90Kai&rft.date=2018-12-01&rft.volume=118&rft.issue=8&rft.spage=1301&rft.epage=1310&rft.pages=1301-1310&rft.issn=0022-4790&rft.eissn=1096-9098&rft_id=info:doi/10.1002/jso.25270&rft_dat=%3Cproquest_cross%3E2132234059%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2136573175&rft_id=info:pmid/30408183&rfr_iscdi=true |