Changing clinical profiles and in-hospital outcomes of octogenarians undergoing cardiac surgery over 18 years: a single-centre experience

Changing clinical profiles and in-hospital outcomes of octogenarians undergoing cardiac surgery over 18 years: a single-centre experience

Abstract OBJECTIVES With an ageing population, increasing numbers of octogenarians are undergoing high-risk cardiac surgery. We examine the changing characteristics and in-hospital outcomes for octogenarians over an 18-year period. METHODS Clinical data from our prospective database for all octogena...

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Veröffentlicht in:Interactive cardiovascular and thoracic surgery 2019-04, Vol.28 (4), p.602-606
Hauptverfasser: Habib, Ahmed M, Hussain, Azhar, Jarvis, Martin, Cowen, Michael E, Chaudhry, Mubarak A, Loubani, Mahmoud, Cale, Alex, Ngaage, Dumbor L
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container_end_page 606
container_issue 4
container_start_page 602
container_title Interactive cardiovascular and thoracic surgery
container_volume 28
creator Habib, Ahmed M
Hussain, Azhar
Jarvis, Martin
Cowen, Michael E
Chaudhry, Mubarak A
Loubani, Mahmoud
Cale, Alex
Ngaage, Dumbor L
description Abstract OBJECTIVES With an ageing population, increasing numbers of octogenarians are undergoing high-risk cardiac surgery. We examine the changing characteristics and in-hospital outcomes for octogenarians over an 18-year period. METHODS Clinical data from our prospective database for all octogenarians who had cardiac surgery from March 1999 through May 2016 were reviewed. We examined trends, risk profiles and in-hospital outcomes over 3 eras, namely early (1999–2004), middle (2005–2010) and late (2011–2016). A multivariable analysis was performed to identify independent predictors for adverse outcomes. RESULTS There were 1022 patients aged 80–94 years in our study cohort. The octogenarian population increased progressively from early to late eras (4.5%, n = 255 vs 7.1%, n = 321 vs 9.3%, n = 446), as the average logistic EuroSCORE predicted mortality (9% vs 9.7% vs 10.1%, P 
doi_str_mv 10.1093/icvts/ivy293
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We examine the changing characteristics and in-hospital outcomes for octogenarians over an 18-year period. METHODS Clinical data from our prospective database for all octogenarians who had cardiac surgery from March 1999 through May 2016 were reviewed. We examined trends, risk profiles and in-hospital outcomes over 3 eras, namely early (1999–2004), middle (2005–2010) and late (2011–2016). A multivariable analysis was performed to identify independent predictors for adverse outcomes. RESULTS There were 1022 patients aged 80–94 years in our study cohort. The octogenarian population increased progressively from early to late eras (4.5%, n = 255 vs 7.1%, n = 321 vs 9.3%, n = 446), as the average logistic EuroSCORE predicted mortality (9% vs 9.7% vs 10.1%, P &lt; 0.01). On the contrary, observed mortality declined substantially (9.4% vs 7.8% vs 4.7%, P = 0.04) over this period. While cardiac morbidity and respiratory comorbidities were more prevalent in the late era, chronic renal failure was more frequent in the early era. Over time, more procedures were performed electively (P = 0.05). Common operations across all eras were coronary artery bypass grafting (CABG), aortic valve replacement and CABG + aortic valve replacement. Emergency operation [odds ratio (OR) 4.96, 95% confidence interval (CI) 1.51–16.35; P &lt; 0.01], poor ejection fraction (OR 3.38, 95% CI 1.80–6.32; P &lt; 0.01) and bypass time (OR 1.01, 95% CI 1.00–1.02; P &lt; 0.01) were predictors of in-hospital mortality. The late era of surgery (OR 0.41, 95% CI 0.23–0.73; P &lt; 0.01) was associated with reduced mortality risk. CONCLUSIONS The operative outcome in this growing surgical population is steadily improving despite the increasing prevalence of comorbidities, and surgery should be performed electively as much as possible.</description><identifier>ISSN: 1569-9285</identifier><identifier>EISSN: 1569-9285</identifier><identifier>DOI: 10.1093/icvts/ivy293</identifier><identifier>PMID: 30412242</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><ispartof>Interactive cardiovascular and thoracic surgery, 2019-04, Vol.28 (4), p.602-606</ispartof><rights>The Author(s) 2018. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. 2018</rights><rights>The Author(s) 2018. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. 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We examine the changing characteristics and in-hospital outcomes for octogenarians over an 18-year period. METHODS Clinical data from our prospective database for all octogenarians who had cardiac surgery from March 1999 through May 2016 were reviewed. We examined trends, risk profiles and in-hospital outcomes over 3 eras, namely early (1999–2004), middle (2005–2010) and late (2011–2016). A multivariable analysis was performed to identify independent predictors for adverse outcomes. RESULTS There were 1022 patients aged 80–94 years in our study cohort. The octogenarian population increased progressively from early to late eras (4.5%, n = 255 vs 7.1%, n = 321 vs 9.3%, n = 446), as the average logistic EuroSCORE predicted mortality (9% vs 9.7% vs 10.1%, P &lt; 0.01). On the contrary, observed mortality declined substantially (9.4% vs 7.8% vs 4.7%, P = 0.04) over this period. While cardiac morbidity and respiratory comorbidities were more prevalent in the late era, chronic renal failure was more frequent in the early era. Over time, more procedures were performed electively (P = 0.05). Common operations across all eras were coronary artery bypass grafting (CABG), aortic valve replacement and CABG + aortic valve replacement. Emergency operation [odds ratio (OR) 4.96, 95% confidence interval (CI) 1.51–16.35; P &lt; 0.01], poor ejection fraction (OR 3.38, 95% CI 1.80–6.32; P &lt; 0.01) and bypass time (OR 1.01, 95% CI 1.00–1.02; P &lt; 0.01) were predictors of in-hospital mortality. The late era of surgery (OR 0.41, 95% CI 0.23–0.73; P &lt; 0.01) was associated with reduced mortality risk. CONCLUSIONS The operative outcome in this growing surgical population is steadily improving despite the increasing prevalence of comorbidities, and surgery should be performed electively as much as possible.</description><issn>1569-9285</issn><issn>1569-9285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kDtPwzAQgC0EolDYmJE3GAj1I82DDVW8pEosMEcX-5IapXawk4r-BP41oS2IielOuk-fdB8hZ5xdc5bLiVGrLkzMai1yuUeO-DTJo1xk0_0_-4gch_DGGM-ZZIdkJFnMhYjFEfmcLcDWxtZUNcYaBQ1tvatMg4GC1dTYaOFCa7rh4PpOueVwcBV1qnM1WvAGbKC91ehrt9GA1wYUDb2v0a-pW6GnPKNrBB9uKNAwUA1GCm3nkeJHi96gVXhCDipoAp7u5pi83t-9zB6j-fPD0-x2HikpZBelMuVJhTwuNc84TxiLc9BaQ5xyYLKKRZqBglJOy7KqsJzmGAuOChlmssy4HJPLrXf4873H0BVLExQ2DVh0fSgEl0KIJGfZgF5tUeVdCB6rovVmCX5dcFZ8xy828Ytt_AE_35n7con6F_6pPQAXW8D17f-qLxX0kq0</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Habib, Ahmed M</creator><creator>Hussain, Azhar</creator><creator>Jarvis, Martin</creator><creator>Cowen, Michael E</creator><creator>Chaudhry, Mubarak A</creator><creator>Loubani, Mahmoud</creator><creator>Cale, Alex</creator><creator>Ngaage, Dumbor L</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190401</creationdate><title>Changing clinical profiles and in-hospital outcomes of octogenarians undergoing cardiac surgery over 18 years: a single-centre experience</title><author>Habib, Ahmed M ; Hussain, Azhar ; Jarvis, Martin ; Cowen, Michael E ; Chaudhry, Mubarak A ; Loubani, Mahmoud ; Cale, Alex ; Ngaage, Dumbor L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-73716fe14bd181160049addda471a03f4278acab35bbffeb59e421ece0e83b813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Habib, Ahmed M</creatorcontrib><creatorcontrib>Hussain, Azhar</creatorcontrib><creatorcontrib>Jarvis, Martin</creatorcontrib><creatorcontrib>Cowen, Michael E</creatorcontrib><creatorcontrib>Chaudhry, Mubarak A</creatorcontrib><creatorcontrib>Loubani, Mahmoud</creatorcontrib><creatorcontrib>Cale, Alex</creatorcontrib><creatorcontrib>Ngaage, Dumbor L</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Interactive cardiovascular and thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Habib, Ahmed M</au><au>Hussain, Azhar</au><au>Jarvis, Martin</au><au>Cowen, Michael E</au><au>Chaudhry, Mubarak A</au><au>Loubani, Mahmoud</au><au>Cale, Alex</au><au>Ngaage, Dumbor L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changing clinical profiles and in-hospital outcomes of octogenarians undergoing cardiac surgery over 18 years: a single-centre experience</atitle><jtitle>Interactive cardiovascular and thoracic surgery</jtitle><addtitle>Interact Cardiovasc Thorac Surg</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>28</volume><issue>4</issue><spage>602</spage><epage>606</epage><pages>602-606</pages><issn>1569-9285</issn><eissn>1569-9285</eissn><abstract>Abstract OBJECTIVES With an ageing population, increasing numbers of octogenarians are undergoing high-risk cardiac surgery. We examine the changing characteristics and in-hospital outcomes for octogenarians over an 18-year period. METHODS Clinical data from our prospective database for all octogenarians who had cardiac surgery from March 1999 through May 2016 were reviewed. We examined trends, risk profiles and in-hospital outcomes over 3 eras, namely early (1999–2004), middle (2005–2010) and late (2011–2016). A multivariable analysis was performed to identify independent predictors for adverse outcomes. RESULTS There were 1022 patients aged 80–94 years in our study cohort. The octogenarian population increased progressively from early to late eras (4.5%, n = 255 vs 7.1%, n = 321 vs 9.3%, n = 446), as the average logistic EuroSCORE predicted mortality (9% vs 9.7% vs 10.1%, P &lt; 0.01). On the contrary, observed mortality declined substantially (9.4% vs 7.8% vs 4.7%, P = 0.04) over this period. While cardiac morbidity and respiratory comorbidities were more prevalent in the late era, chronic renal failure was more frequent in the early era. Over time, more procedures were performed electively (P = 0.05). Common operations across all eras were coronary artery bypass grafting (CABG), aortic valve replacement and CABG + aortic valve replacement. Emergency operation [odds ratio (OR) 4.96, 95% confidence interval (CI) 1.51–16.35; P &lt; 0.01], poor ejection fraction (OR 3.38, 95% CI 1.80–6.32; P &lt; 0.01) and bypass time (OR 1.01, 95% CI 1.00–1.02; P &lt; 0.01) were predictors of in-hospital mortality. The late era of surgery (OR 0.41, 95% CI 0.23–0.73; P &lt; 0.01) was associated with reduced mortality risk. CONCLUSIONS The operative outcome in this growing surgical population is steadily improving despite the increasing prevalence of comorbidities, and surgery should be performed electively as much as possible.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>30412242</pmid><doi>10.1093/icvts/ivy293</doi><tpages>5</tpages></addata></record>
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title Changing clinical profiles and in-hospital outcomes of octogenarians undergoing cardiac surgery over 18 years: a single-centre experience
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