TREK-2 Mediates the Neuroprotective Effect of Isoflurane Preconditioning Against Acute Cerebral Ischemia in the Rat

It is known that preconditional treatment with volatile anesthetics can induce tolerance of the brain to stroke. A previous study demonstrated that the involvement of TREK-1, a two-pore domain K+ channel, in sevoflurane preconditioning induced neuroprotection against focal cerebral ischemia in rats....

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Veröffentlicht in:	Rejuvenation research 2019-08, Vol.22 (4), p.325-334
Hauptverfasser:	Zhao, Guangchao, Yang, LuJia, Wang, Shiquan, Cai, Min, Sun, Sisi, Dong, Hailong, Xiong, Lize
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Brain Ischemia - metabolism Brain Ischemia - pathology Down-Regulation - drug effects Extracellular Signal-Regulated MAP Kinases - metabolism Infarction, Middle Cerebral Artery - complications Ischemic Preconditioning Isoflurane - pharmacology Neuroprotective Agents - pharmacology Original Articles Phosphorylation - drug effects Potassium Channels, Tandem Pore Domain - metabolism Rats, Sprague-Dawley Reperfusion Injury - metabolism Reperfusion Injury - pathology
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