Systemic administration of lipopolysaccharide impairs glutathione redox state and object recognition in male mice. The effect of PARP-1 inhibitor

Our previous data demonstrated that systemic inflammation evoked by intraperitoneal injection of lipopolysaccharide (LPS; 1 mg/kg b.w.) induces morphological and biochemical changes in the brain, including alterations of poly(ADP-ribose) polymerase-1 (PARP-1) activity and expression of several genes...

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Veröffentlicht in:	Folia neuropathologica 2009, Vol.47 (4), p.321-328
Hauptverfasser:	Jacewicz, Maria, Czapski, Grzegorz A, Katkowska, Inna, Strosznajder, Robert P
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Benzamides - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cognition - drug effects Cognition - physiology Enzyme Inhibitors - pharmacology Exploratory Behavior - drug effects Exploratory Behavior - physiology Glutathione - metabolism Glutathione Disulfide - metabolism Inflammation - chemically induced Inflammation - physiopathology Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Lipopolysaccharides - toxicity Male Mice Mice, Inbred C57BL Motor Activity - drug effects Motor Activity - physiology Oxidation-Reduction Pattern Recognition, Visual - drug effects Pattern Recognition, Visual - physiology Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - metabolism Recognition (Psychology) - drug effects Recognition (Psychology) - physiology Space Perception - drug effects Space Perception - physiology Spatial Behavior - drug effects Spatial Behavior - physiology Time Factors
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