Systemic administration of lipopolysaccharide impairs glutathione redox state and object recognition in male mice. The effect of PARP-1 inhibitor
Our previous data demonstrated that systemic inflammation evoked by intraperitoneal injection of lipopolysaccharide (LPS; 1 mg/kg b.w.) induces morphological and biochemical changes in the brain, including alterations of poly(ADP-ribose) polymerase-1 (PARP-1) activity and expression of several genes...
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| Veröffentlicht in: | Folia neuropathologica 2009, Vol.47 (4), p.321-328 |
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| creator | Jacewicz, Maria Czapski, Grzegorz A Katkowska, Inna Strosznajder, Robert P |
| description | Our previous data demonstrated that systemic inflammation evoked by intraperitoneal injection of lipopolysaccharide (LPS; 1 mg/kg b.w.) induces morphological and biochemical changes in the brain, including alterations of poly(ADP-ribose) polymerase-1 (PARP-1) activity and expression of several genes. In this study, the effect of systemic inflammatory response (SIR) on glutathione redox state and on cognition, spatial memory and locomotor activity was evaluated by using spectrophotometric method, object recognition test, Morris water-maze and open-field tests, respectively. The effect of PARP-1 inhibitor was included in this study. Our data indicated that SIR significantly decreases reduced glutathione (GSH) level, enhances its disulfide form (GSSG) and decreases glutathione reductase activity. Moreover, SIR affects the object recognition and locomotor activity but has negligible effect on spatial memory. PARP-1 inhibitor protects against LPS-evoked recognition impairment and significantly improves spatial memory in LPS-treated mice. The effect of PARP-1 inhibitor could be in part connected with lowering of PARP-1 involvement in regulation of transcription of several pro-inflammatory genes. Moreover, PARP-1 inhibitors may modulate glutamatergic receptor signaling that plays an important role in learning and memory. |
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The effect of PARP-1 inhibitor was included in this study. Our data indicated that SIR significantly decreases reduced glutathione (GSH) level, enhances its disulfide form (GSSG) and decreases glutathione reductase activity. Moreover, SIR affects the object recognition and locomotor activity but has negligible effect on spatial memory. PARP-1 inhibitor protects against LPS-evoked recognition impairment and significantly improves spatial memory in LPS-treated mice. The effect of PARP-1 inhibitor could be in part connected with lowering of PARP-1 involvement in regulation of transcription of several pro-inflammatory genes. Moreover, PARP-1 inhibitors may modulate glutamatergic receptor signaling that plays an important role in learning and memory.</description><identifier>ISSN: 1641-4640</identifier><identifier>EISSN: 1509-572X</identifier><identifier>PMID: 20054784</identifier><language>eng</language><publisher>Poland</publisher><subject>Analysis of Variance ; Animals ; Benzamides - pharmacology ; Cerebral Cortex - drug effects ; Cerebral Cortex - metabolism ; Cognition - drug effects ; Cognition - physiology ; Enzyme Inhibitors - pharmacology ; Exploratory Behavior - drug effects ; Exploratory Behavior - physiology ; Glutathione - metabolism ; Glutathione Disulfide - metabolism ; Inflammation - chemically induced ; Inflammation - physiopathology ; Lipid Peroxidation - drug effects ; Lipid Peroxidation - physiology ; Lipopolysaccharides - toxicity ; Male ; Mice ; Mice, Inbred C57BL ; Motor Activity - drug effects ; Motor Activity - physiology ; Oxidation-Reduction ; Pattern Recognition, Visual - drug effects ; Pattern Recognition, Visual - physiology ; Poly (ADP-Ribose) Polymerase-1 ; Poly(ADP-ribose) Polymerase Inhibitors ; Poly(ADP-ribose) Polymerases - metabolism ; Recognition (Psychology) - drug effects ; Recognition (Psychology) - physiology ; Space Perception - drug effects ; Space Perception - physiology ; Spatial Behavior - drug effects ; Spatial Behavior - physiology ; Time Factors</subject><ispartof>Folia neuropathologica, 2009, Vol.47 (4), p.321-328</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20054784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jacewicz, Maria</creatorcontrib><creatorcontrib>Czapski, Grzegorz A</creatorcontrib><creatorcontrib>Katkowska, Inna</creatorcontrib><creatorcontrib>Strosznajder, Robert P</creatorcontrib><title>Systemic administration of lipopolysaccharide impairs glutathione redox state and object recognition in male mice. The effect of PARP-1 inhibitor</title><title>Folia neuropathologica</title><addtitle>Folia Neuropathol</addtitle><description>Our previous data demonstrated that systemic inflammation evoked by intraperitoneal injection of lipopolysaccharide (LPS; 1 mg/kg b.w.) induces morphological and biochemical changes in the brain, including alterations of poly(ADP-ribose) polymerase-1 (PARP-1) activity and expression of several genes. In this study, the effect of systemic inflammatory response (SIR) on glutathione redox state and on cognition, spatial memory and locomotor activity was evaluated by using spectrophotometric method, object recognition test, Morris water-maze and open-field tests, respectively. The effect of PARP-1 inhibitor was included in this study. Our data indicated that SIR significantly decreases reduced glutathione (GSH) level, enhances its disulfide form (GSSG) and decreases glutathione reductase activity. Moreover, SIR affects the object recognition and locomotor activity but has negligible effect on spatial memory. PARP-1 inhibitor protects against LPS-evoked recognition impairment and significantly improves spatial memory in LPS-treated mice. The effect of PARP-1 inhibitor could be in part connected with lowering of PARP-1 involvement in regulation of transcription of several pro-inflammatory genes. Moreover, PARP-1 inhibitors may modulate glutamatergic receptor signaling that plays an important role in learning and memory.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Benzamides - pharmacology</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cognition - drug effects</subject><subject>Cognition - physiology</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Exploratory Behavior - drug effects</subject><subject>Exploratory Behavior - physiology</subject><subject>Glutathione - metabolism</subject><subject>Glutathione Disulfide - metabolism</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - physiopathology</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipid Peroxidation - physiology</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Motor Activity - drug effects</subject><subject>Motor Activity - physiology</subject><subject>Oxidation-Reduction</subject><subject>Pattern Recognition, Visual - drug effects</subject><subject>Pattern Recognition, Visual - physiology</subject><subject>Poly (ADP-Ribose) Polymerase-1</subject><subject>Poly(ADP-ribose) Polymerase Inhibitors</subject><subject>Poly(ADP-ribose) Polymerases - metabolism</subject><subject>Recognition (Psychology) - drug effects</subject><subject>Recognition (Psychology) - physiology</subject><subject>Space Perception - drug effects</subject><subject>Space Perception - physiology</subject><subject>Spatial Behavior - drug effects</subject><subject>Spatial Behavior - physiology</subject><subject>Time Factors</subject><issn>1641-4640</issn><issn>1509-572X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kF9LwzAUxYsobk6_guTJt0qSJun6OIb_YODQCb6VNLlZM9qmJhm4j-E3Nup8OvcefpwD5ySbEo6rnJf0_TTdgpGcCYYn2UUIO4wZZxU9zyYUY87KOZtmX6-HEKG3Cknd28GG6GW0bkDOoM6ObnTdIUilWumtBmT7UVof0LbbRxnbBALyoN0nCukHJAeNXLMDFZOt3Hawv2F2QL3sAKUeuEWbFhAY8wOllvXiZZ2ThLS2sdH5y-zMyC7A1VFn2dv93Wb5mK-eH56Wi1U-UlzFvKHScGEwMxgrVfE5lKoSyhhCNCNSQyUoF0QRLYpSa8YUBiWFYHNmSkF1Mctu_nJH7z72EGLd26Cg6-QAbh9qSgpScUwSeH0E900Puh697aU_1P8jFt-2q3IK</recordid><startdate>2009</startdate><enddate>2009</enddate><creator>Jacewicz, Maria</creator><creator>Czapski, Grzegorz A</creator><creator>Katkowska, Inna</creator><creator>Strosznajder, Robert P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope></search><sort><creationdate>2009</creationdate><title>Systemic administration of lipopolysaccharide impairs glutathione redox state and object recognition in male mice. The effect of PARP-1 inhibitor</title><author>Jacewicz, Maria ; Czapski, Grzegorz A ; Katkowska, Inna ; Strosznajder, Robert P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-b2af56f04f00cc958e7c96cff11d41ade962561c1d637dd44c0eca66484f762d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Benzamides - pharmacology</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cognition - drug effects</topic><topic>Cognition - physiology</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Exploratory Behavior - drug effects</topic><topic>Exploratory Behavior - physiology</topic><topic>Glutathione - metabolism</topic><topic>Glutathione Disulfide - metabolism</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - physiopathology</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipid Peroxidation - physiology</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Motor Activity - drug effects</topic><topic>Motor Activity - physiology</topic><topic>Oxidation-Reduction</topic><topic>Pattern Recognition, Visual - drug effects</topic><topic>Pattern Recognition, Visual - physiology</topic><topic>Poly (ADP-Ribose) Polymerase-1</topic><topic>Poly(ADP-ribose) Polymerase Inhibitors</topic><topic>Poly(ADP-ribose) Polymerases - metabolism</topic><topic>Recognition (Psychology) - drug effects</topic><topic>Recognition (Psychology) - physiology</topic><topic>Space Perception - drug effects</topic><topic>Space Perception - physiology</topic><topic>Spatial Behavior - drug effects</topic><topic>Spatial Behavior - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jacewicz, Maria</creatorcontrib><creatorcontrib>Czapski, Grzegorz A</creatorcontrib><creatorcontrib>Katkowska, Inna</creatorcontrib><creatorcontrib>Strosznajder, Robert P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><jtitle>Folia neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jacewicz, Maria</au><au>Czapski, Grzegorz A</au><au>Katkowska, Inna</au><au>Strosznajder, Robert P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic administration of lipopolysaccharide impairs glutathione redox state and object recognition in male mice. The effect of PARP-1 inhibitor</atitle><jtitle>Folia neuropathologica</jtitle><addtitle>Folia Neuropathol</addtitle><date>2009</date><risdate>2009</risdate><volume>47</volume><issue>4</issue><spage>321</spage><epage>328</epage><pages>321-328</pages><issn>1641-4640</issn><eissn>1509-572X</eissn><abstract>Our previous data demonstrated that systemic inflammation evoked by intraperitoneal injection of lipopolysaccharide (LPS; 1 mg/kg b.w.) induces morphological and biochemical changes in the brain, including alterations of poly(ADP-ribose) polymerase-1 (PARP-1) activity and expression of several genes. In this study, the effect of systemic inflammatory response (SIR) on glutathione redox state and on cognition, spatial memory and locomotor activity was evaluated by using spectrophotometric method, object recognition test, Morris water-maze and open-field tests, respectively. The effect of PARP-1 inhibitor was included in this study. Our data indicated that SIR significantly decreases reduced glutathione (GSH) level, enhances its disulfide form (GSSG) and decreases glutathione reductase activity. Moreover, SIR affects the object recognition and locomotor activity but has negligible effect on spatial memory. PARP-1 inhibitor protects against LPS-evoked recognition impairment and significantly improves spatial memory in LPS-treated mice. The effect of PARP-1 inhibitor could be in part connected with lowering of PARP-1 involvement in regulation of transcription of several pro-inflammatory genes. Moreover, PARP-1 inhibitors may modulate glutamatergic receptor signaling that plays an important role in learning and memory.</abstract><cop>Poland</cop><pmid>20054784</pmid><tpages>8</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Benzamides - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cognition - drug effects Cognition - physiology Enzyme Inhibitors - pharmacology Exploratory Behavior - drug effects Exploratory Behavior - physiology Glutathione - metabolism Glutathione Disulfide - metabolism Inflammation - chemically induced Inflammation - physiopathology Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Lipopolysaccharides - toxicity Male Mice Mice, Inbred C57BL Motor Activity - drug effects Motor Activity - physiology Oxidation-Reduction Pattern Recognition, Visual - drug effects Pattern Recognition, Visual - physiology Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - metabolism Recognition (Psychology) - drug effects Recognition (Psychology) - physiology Space Perception - drug effects Space Perception - physiology Spatial Behavior - drug effects Spatial Behavior - physiology Time Factors |
| title | Systemic administration of lipopolysaccharide impairs glutathione redox state and object recognition in male mice. The effect of PARP-1 inhibitor |
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