Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth

Two related Rho GTPase-activating proteins, DLC-1 (deleted in liver cancer 1) and DLC-2, are emerging as bona fide tumor suppressor genes that inhibit cancer cell growth. In this report, we characterized a gene on chromosome Xq13 that encodes DLC-3 (also known as KIAA0189 and STARD8 ), a third membe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2007-07, Vol.26 (31), p.4580-4589
Hauptverfasser:	Durkin, M E, Ullmannova, V, Guan, M, Popescu, N C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Apoptosis Biological and medical sciences Breast - metabolism Breast cancer Breast Neoplasms - metabolism Cancer Carcinogenesis Causes of Cell Biology Cell growth Cell physiology Cell Proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosomes Down-Regulation Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene expression Genes, Tumor Suppressor Genetic aspects Genetics GTPase-activating protein GTPase-Activating Proteins - metabolism Health aspects Hepatocytes Human Genetics Humans Internal Medicine Liver cancer Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Medicine Medicine & Public Health Molecular and cellular biology Molecular Sequence Data Neoplasms - metabolism Nephrology. Urinary tract diseases Oncology original-article Ovarian cancer Ovaries Polymerase chain reaction Prostate - metabolism Prostate cancer Prostate carcinoma Prostatic Neoplasms - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA-directed DNA polymerase Transfection Tumor cell lines Tumor suppressor genes Tumor Suppressor Proteins - genetics Tumorigenesis Tumors Tumors of the urinary system Urinary tract. Prostate gland Uterine cancer Uterus
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!