HSD17B13 and Chronic Liver Disease in Blacks and Hispanics

The established association between variant HSD17B13 and protection against chronic liver disease has been replicated. A newly discovered, probably damaging variant (with an allele frequency of 18.7% in blacks and 2.4% in Hispanics) is associated with protection against the disease.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2018-11, Vol.379 (19), p.1876-1877
Hauptverfasser:	Kozlitina, Julia, Stender, Stefan, Hobbs, Helen H, Cohen, Jonathan C
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases - genetics Adult African Americans Child Chronic Disease Frameshift Mutation Gene frequency Genetic Predisposition to Disease Hispanic Americans Hispanic people Humans Liver - chemistry Liver diseases Liver Diseases - ethnology Liver Diseases - genetics Loss of Function Mutation Triglycerides - analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	1877
container_issue	19
container_start_page	1876
container_title	The New England journal of medicine
container_volume	379
creator	Kozlitina, Julia Stender, Stefan Hobbs, Helen H Cohen, Jonathan C
description	The established association between variant HSD17B13 and protection against chronic liver disease has been replicated. A newly discovered, probably damaging variant (with an allele frequency of 18.7% in blacks and 2.4% in Hispanics) is associated with protection against the disease.
doi_str_mv	10.1056/NEJMc1804027
format	Article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2131241894</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2130857810</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-444da88f3e28e79f523706191aea7df6422f0a73f9acd2fb4d08c9883d6278df3</originalsourceid><addsrcrecordid>eNpt0DtPwzAUBWALgaAUNmYUCQYGAr62E9ts9AEFFRiAOXL9EClNUuwGiX-PSwtCiLvc5dPR0UHoAPAZ4Cw_vx_e3mkQmGHCN1AHMkpTxnC-iToYE5EyLukO2g1hiuMBk9toh0ZNJYMOuhg9DoD3gCaqNkn_xTd1qZNx-W59MiiDVcEmZZ30Zkq_hi8zKsNcRRT20JZTs2D317-Lnq-GT_1ROn64vulfjlNNRb6IXZhRQjhqibBcuoxQjnOQoKzixuWMEIcVp04qbYibMIOFlkJQkxMujKNddLLKnfvmrbVhUVRl0HY2U7Vt2lAQoEAYCMkiPfpDp03r69huqbDIuAAc1elKad-E4K0r5r6slP8oABfLTYvfm0Z-uA5tJ5U1P_h7xAiOV6CqQlHbafV_zichKXga</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2130857810</pqid></control><display><type>article</type><title>HSD17B13 and Chronic Liver Disease in Blacks and Hispanics</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>New England Journal of Medicine</source><creator>Kozlitina, Julia ; Stender, Stefan ; Hobbs, Helen H ; Cohen, Jonathan C</creator><creatorcontrib>Kozlitina, Julia ; Stender, Stefan ; Hobbs, Helen H ; Cohen, Jonathan C</creatorcontrib><description>The established association between variant HSD17B13 and protection against chronic liver disease has been replicated. A newly discovered, probably damaging variant (with an allele frequency of 18.7% in blacks and 2.4% in Hispanics) is associated with protection against the disease.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMc1804027</identifier><identifier>PMID: 30403941</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>17-Hydroxysteroid Dehydrogenases - genetics ; Adult ; African Americans ; Child ; Chronic Disease ; Frameshift Mutation ; Gene frequency ; Genetic Predisposition to Disease ; Hispanic Americans ; Hispanic people ; Humans ; Liver - chemistry ; Liver diseases ; Liver Diseases - ethnology ; Liver Diseases - genetics ; Loss of Function Mutation ; Triglycerides - analysis</subject><ispartof>The New England journal of medicine, 2018-11, Vol.379 (19), p.1876-1877</ispartof><rights>Copyright © 2018 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-444da88f3e28e79f523706191aea7df6422f0a73f9acd2fb4d08c9883d6278df3</citedby><cites>FETCH-LOGICAL-c386t-444da88f3e28e79f523706191aea7df6422f0a73f9acd2fb4d08c9883d6278df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMc1804027$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMc1804027$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30403941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kozlitina, Julia</creatorcontrib><creatorcontrib>Stender, Stefan</creatorcontrib><creatorcontrib>Hobbs, Helen H</creatorcontrib><creatorcontrib>Cohen, Jonathan C</creatorcontrib><title>HSD17B13 and Chronic Liver Disease in Blacks and Hispanics</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>The established association between variant HSD17B13 and protection against chronic liver disease has been replicated. A newly discovered, probably damaging variant (with an allele frequency of 18.7% in blacks and 2.4% in Hispanics) is associated with protection against the disease.</description><subject>17-Hydroxysteroid Dehydrogenases - genetics</subject><subject>Adult</subject><subject>African Americans</subject><subject>Child</subject><subject>Chronic Disease</subject><subject>Frameshift Mutation</subject><subject>Gene frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Hispanic Americans</subject><subject>Hispanic people</subject><subject>Humans</subject><subject>Liver - chemistry</subject><subject>Liver diseases</subject><subject>Liver Diseases - ethnology</subject><subject>Liver Diseases - genetics</subject><subject>Loss of Function Mutation</subject><subject>Triglycerides - analysis</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0DtPwzAUBWALgaAUNmYUCQYGAr62E9ts9AEFFRiAOXL9EClNUuwGiX-PSwtCiLvc5dPR0UHoAPAZ4Cw_vx_e3mkQmGHCN1AHMkpTxnC-iToYE5EyLukO2g1hiuMBk9toh0ZNJYMOuhg9DoD3gCaqNkn_xTd1qZNx-W59MiiDVcEmZZ30Zkq_hi8zKsNcRRT20JZTs2D317-Lnq-GT_1ROn64vulfjlNNRb6IXZhRQjhqibBcuoxQjnOQoKzixuWMEIcVp04qbYibMIOFlkJQkxMujKNddLLKnfvmrbVhUVRl0HY2U7Vt2lAQoEAYCMkiPfpDp03r69huqbDIuAAc1elKad-E4K0r5r6slP8oABfLTYvfm0Z-uA5tJ5U1P_h7xAiOV6CqQlHbafV_zichKXga</recordid><startdate>20181108</startdate><enddate>20181108</enddate><creator>Kozlitina, Julia</creator><creator>Stender, Stefan</creator><creator>Hobbs, Helen H</creator><creator>Cohen, Jonathan C</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20181108</creationdate><title>HSD17B13 and Chronic Liver Disease in Blacks and Hispanics</title><author>Kozlitina, Julia ; Stender, Stefan ; Hobbs, Helen H ; Cohen, Jonathan C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-444da88f3e28e79f523706191aea7df6422f0a73f9acd2fb4d08c9883d6278df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>17-Hydroxysteroid Dehydrogenases - genetics</topic><topic>Adult</topic><topic>African Americans</topic><topic>Child</topic><topic>Chronic Disease</topic><topic>Frameshift Mutation</topic><topic>Gene frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Hispanic Americans</topic><topic>Hispanic people</topic><topic>Humans</topic><topic>Liver - chemistry</topic><topic>Liver diseases</topic><topic>Liver Diseases - ethnology</topic><topic>Liver Diseases - genetics</topic><topic>Loss of Function Mutation</topic><topic>Triglycerides - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kozlitina, Julia</creatorcontrib><creatorcontrib>Stender, Stefan</creatorcontrib><creatorcontrib>Hobbs, Helen H</creatorcontrib><creatorcontrib>Cohen, Jonathan C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kozlitina, Julia</au><au>Stender, Stefan</au><au>Hobbs, Helen H</au><au>Cohen, Jonathan C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HSD17B13 and Chronic Liver Disease in Blacks and Hispanics</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2018-11-08</date><risdate>2018</risdate><volume>379</volume><issue>19</issue><spage>1876</spage><epage>1877</epage><pages>1876-1877</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>The established association between variant HSD17B13 and protection against chronic liver disease has been replicated. A newly discovered, probably damaging variant (with an allele frequency of 18.7% in blacks and 2.4% in Hispanics) is associated with protection against the disease.</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>30403941</pmid><doi>10.1056/NEJMc1804027</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 0028-4793
ispartof	The New England journal of medicine, 2018-11, Vol.379 (19), p.1876-1877
issn	0028-4793 1533-4406
language	eng
recordid	cdi_proquest_miscellaneous_2131241894
source	MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine
subjects	17-Hydroxysteroid Dehydrogenases - genetics Adult African Americans Child Chronic Disease Frameshift Mutation Gene frequency Genetic Predisposition to Disease Hispanic Americans Hispanic people Humans Liver - chemistry Liver diseases Liver Diseases - ethnology Liver Diseases - genetics Loss of Function Mutation Triglycerides - analysis
title	HSD17B13 and Chronic Liver Disease in Blacks and Hispanics
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T11%3A28%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HSD17B13%20and%20Chronic%20Liver%20Disease%20in%20Blacks%20and%20Hispanics&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Kozlitina,%20Julia&rft.date=2018-11-08&rft.volume=379&rft.issue=19&rft.spage=1876&rft.epage=1877&rft.pages=1876-1877&rft.issn=0028-4793&rft.eissn=1533-4406&rft_id=info:doi/10.1056/NEJMc1804027&rft_dat=%3Cproquest_cross%3E2130857810%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2130857810&rft_id=info:pmid/30403941&rfr_iscdi=true