The effect of dietary ginseng polysaccharide supplementation on porcine milk‐derived esRNAs involved in the host immune responses
Ginseng polysaccharides (GPS) have been well known as an immune modulator. This study was conducted to investigate the effects of dietary supplemental GPS on the immune responses involved in sow’s milk‐derived exosomal shuttle RNAs (esRNAs) using RNA‐Seq and miRNA‐Seq. Of the 213 identified miRNA ty...
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| Veröffentlicht in: | Journal of animal physiology and animal nutrition 2019-01, Vol.103 (1), p.276-282 |
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| container_title | Journal of animal physiology and animal nutrition |
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| creator | Sun, Jiajie Xiong, Jiali Yao, Liyuan Chen, Ting Luo, Junyi Xi, Qianyun Zhang, Yongliang |
| description | Ginseng polysaccharides (GPS) have been well known as an immune modulator. This study was conducted to investigate the effects of dietary supplemental GPS on the immune responses involved in sow’s milk‐derived exosomal shuttle RNAs (esRNAs) using RNA‐Seq and miRNA‐Seq. Of the 213 identified miRNA types, a total of 26 conserved miRNAs were differently expressed in response to GPS supplementation, including 10 up‐regulated and 16 down‐regulated miRNAs in GPS feeding group. In addition, exosomal transcriptome analysis identified 14,696 protein‐coding genes in sow’s milk exosomes, and 283 genes with 204 and 79 candidates showing up and down‐regulation were significantly responded to GPS supplementation. Integrated analysis of each differently expressed miRNA with significantly expressed genes further revealed the presence of 51 highly conserved miRNA–gene interactions that were annotated to be related to immunoregulatory functions. This work provided an important advance in the functional identification of dietary GPS supplementation and more fundamental information about how GPS promoted the immune response and healthy growth of the infant from mothers at molecular levels. |
| doi_str_mv | 10.1111/jpn.12993 |
| format | Article |
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This study was conducted to investigate the effects of dietary supplemental GPS on the immune responses involved in sow’s milk‐derived exosomal shuttle RNAs (esRNAs) using RNA‐Seq and miRNA‐Seq. Of the 213 identified miRNA types, a total of 26 conserved miRNAs were differently expressed in response to GPS supplementation, including 10 up‐regulated and 16 down‐regulated miRNAs in GPS feeding group. In addition, exosomal transcriptome analysis identified 14,696 protein‐coding genes in sow’s milk exosomes, and 283 genes with 204 and 79 candidates showing up and down‐regulation were significantly responded to GPS supplementation. Integrated analysis of each differently expressed miRNA with significantly expressed genes further revealed the presence of 51 highly conserved miRNA–gene interactions that were annotated to be related to immunoregulatory functions. This work provided an important advance in the functional identification of dietary GPS supplementation and more fundamental information about how GPS promoted the immune response and healthy growth of the infant from mothers at molecular levels.</description><identifier>ISSN: 0931-2439</identifier><identifier>EISSN: 1439-0396</identifier><identifier>DOI: 10.1111/jpn.12993</identifier><identifier>PMID: 30407669</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Animal Feed ; Animal Nutritional Physiological Phenomena ; Animals ; Diet ; Diet - veterinary ; Dietary Supplements ; esRNAs ; exosome ; Exosomes ; Exosomes - chemistry ; Functionals ; Gene expression ; Gene Expression Profiling ; Genes ; Ginseng ; Ginseng polysaccharide ; Immune response ; Immune system ; Immunoregulation ; Milk ; Milk - chemistry ; Milk - metabolism ; miRNA ; Panax - chemistry ; Polysaccharides ; Polysaccharides - chemistry ; Polysaccharides - pharmacology ; Proteins ; Ribonucleic acid ; RNA ; RNA - chemistry ; RNA - metabolism ; Saccharides ; sow ; Swine - immunology ; Swine - metabolism ; Transcriptome</subject><ispartof>Journal of animal physiology and animal nutrition, 2019-01, Vol.103 (1), p.276-282</ispartof><rights>2018 Blackwell Verlag GmbH</rights><rights>2018 Blackwell Verlag GmbH.</rights><rights>2019 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3883-92c2881ec7de097e557579a07490972b1ff0def1ad51714f9da1e385e2905b033</citedby><cites>FETCH-LOGICAL-c3883-92c2881ec7de097e557579a07490972b1ff0def1ad51714f9da1e385e2905b033</cites><orcidid>0000-0003-0274-2211</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjpn.12993$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjpn.12993$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30407669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Jiajie</creatorcontrib><creatorcontrib>Xiong, Jiali</creatorcontrib><creatorcontrib>Yao, Liyuan</creatorcontrib><creatorcontrib>Chen, Ting</creatorcontrib><creatorcontrib>Luo, Junyi</creatorcontrib><creatorcontrib>Xi, Qianyun</creatorcontrib><creatorcontrib>Zhang, Yongliang</creatorcontrib><title>The effect of dietary ginseng polysaccharide supplementation on porcine milk‐derived esRNAs involved in the host immune responses</title><title>Journal of animal physiology and animal nutrition</title><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><description>Ginseng polysaccharides (GPS) have been well known as an immune modulator. This study was conducted to investigate the effects of dietary supplemental GPS on the immune responses involved in sow’s milk‐derived exosomal shuttle RNAs (esRNAs) using RNA‐Seq and miRNA‐Seq. Of the 213 identified miRNA types, a total of 26 conserved miRNAs were differently expressed in response to GPS supplementation, including 10 up‐regulated and 16 down‐regulated miRNAs in GPS feeding group. In addition, exosomal transcriptome analysis identified 14,696 protein‐coding genes in sow’s milk exosomes, and 283 genes with 204 and 79 candidates showing up and down‐regulation were significantly responded to GPS supplementation. Integrated analysis of each differently expressed miRNA with significantly expressed genes further revealed the presence of 51 highly conserved miRNA–gene interactions that were annotated to be related to immunoregulatory functions. This work provided an important advance in the functional identification of dietary GPS supplementation and more fundamental information about how GPS promoted the immune response and healthy growth of the infant from mothers at molecular levels.</description><subject>Animal Feed</subject><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Diet</subject><subject>Diet - veterinary</subject><subject>Dietary Supplements</subject><subject>esRNAs</subject><subject>exosome</subject><subject>Exosomes</subject><subject>Exosomes - chemistry</subject><subject>Functionals</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Genes</subject><subject>Ginseng</subject><subject>Ginseng polysaccharide</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunoregulation</subject><subject>Milk</subject><subject>Milk - chemistry</subject><subject>Milk - metabolism</subject><subject>miRNA</subject><subject>Panax - chemistry</subject><subject>Polysaccharides</subject><subject>Polysaccharides - chemistry</subject><subject>Polysaccharides - pharmacology</subject><subject>Proteins</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA - chemistry</subject><subject>RNA - metabolism</subject><subject>Saccharides</subject><subject>sow</subject><subject>Swine - immunology</subject><subject>Swine - metabolism</subject><subject>Transcriptome</subject><issn>0931-2439</issn><issn>1439-0396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1OGzEQxy3UCkLaAy-ALHGBwwZ_ZOP1ESE-WkWAKnpeOfaYOOzai70Lyg2JF-AZ-yQ1DeVQqdZI1ox-85_R_BHao2RC8ztedX5CmZR8C43olMuCcDn7hEZEclqwXNhBuymtCKGiJLNttMPJlIjZTI7Qy-0SMFgLusfBYuOgV3GN75xP4O9wF5p1UlovVXQGcBq6roEWfK96FzzO0YWonQfcuub-1_OrgegewWBIP65OEnb-MTRvufO4z5OWIfXYte2QOyKkLuQx6Qv6bFWT4Ov7P0Y_z89uTy-L-fXFt9OTeaF5VfFCMs2qioIWBogUUJaiFFIRMZU5ZQtqLTFgqTIlFXRqpVEUeFUCk6RcEM7H6HCj28XwMEDq69YlDU2jPIQh1YxyyniVmzN68A-6CkP0ebtMCSIpY_m4Y3S0oXQMKUWwdRddm-9XU1K_OVNnZ-o_zmR2_11xWLRgPsi_VmTgeAM8uQbW_1eqv99cbSR_A1Szmg0</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Sun, Jiajie</creator><creator>Xiong, Jiali</creator><creator>Yao, Liyuan</creator><creator>Chen, Ting</creator><creator>Luo, Junyi</creator><creator>Xi, Qianyun</creator><creator>Zhang, Yongliang</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0274-2211</orcidid></search><sort><creationdate>201901</creationdate><title>The effect of dietary ginseng polysaccharide supplementation on porcine milk‐derived esRNAs involved in the host immune responses</title><author>Sun, Jiajie ; Xiong, Jiali ; Yao, Liyuan ; Chen, Ting ; Luo, Junyi ; Xi, Qianyun ; Zhang, Yongliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3883-92c2881ec7de097e557579a07490972b1ff0def1ad51714f9da1e385e2905b033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal Feed</topic><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>Diet</topic><topic>Diet - veterinary</topic><topic>Dietary Supplements</topic><topic>esRNAs</topic><topic>exosome</topic><topic>Exosomes</topic><topic>Exosomes - chemistry</topic><topic>Functionals</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Genes</topic><topic>Ginseng</topic><topic>Ginseng polysaccharide</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunoregulation</topic><topic>Milk</topic><topic>Milk - chemistry</topic><topic>Milk - metabolism</topic><topic>miRNA</topic><topic>Panax - chemistry</topic><topic>Polysaccharides</topic><topic>Polysaccharides - chemistry</topic><topic>Polysaccharides - pharmacology</topic><topic>Proteins</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA - chemistry</topic><topic>RNA - metabolism</topic><topic>Saccharides</topic><topic>sow</topic><topic>Swine - immunology</topic><topic>Swine - metabolism</topic><topic>Transcriptome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Jiajie</creatorcontrib><creatorcontrib>Xiong, Jiali</creatorcontrib><creatorcontrib>Yao, Liyuan</creatorcontrib><creatorcontrib>Chen, Ting</creatorcontrib><creatorcontrib>Luo, Junyi</creatorcontrib><creatorcontrib>Xi, Qianyun</creatorcontrib><creatorcontrib>Zhang, Yongliang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal physiology and animal nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Jiajie</au><au>Xiong, Jiali</au><au>Yao, Liyuan</au><au>Chen, Ting</au><au>Luo, Junyi</au><au>Xi, Qianyun</au><au>Zhang, Yongliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of dietary ginseng polysaccharide supplementation on porcine milk‐derived esRNAs involved in the host immune responses</atitle><jtitle>Journal of animal physiology and animal nutrition</jtitle><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><date>2019-01</date><risdate>2019</risdate><volume>103</volume><issue>1</issue><spage>276</spage><epage>282</epage><pages>276-282</pages><issn>0931-2439</issn><eissn>1439-0396</eissn><abstract>Ginseng polysaccharides (GPS) have been well known as an immune modulator. This study was conducted to investigate the effects of dietary supplemental GPS on the immune responses involved in sow’s milk‐derived exosomal shuttle RNAs (esRNAs) using RNA‐Seq and miRNA‐Seq. Of the 213 identified miRNA types, a total of 26 conserved miRNAs were differently expressed in response to GPS supplementation, including 10 up‐regulated and 16 down‐regulated miRNAs in GPS feeding group. In addition, exosomal transcriptome analysis identified 14,696 protein‐coding genes in sow’s milk exosomes, and 283 genes with 204 and 79 candidates showing up and down‐regulation were significantly responded to GPS supplementation. Integrated analysis of each differently expressed miRNA with significantly expressed genes further revealed the presence of 51 highly conserved miRNA–gene interactions that were annotated to be related to immunoregulatory functions. This work provided an important advance in the functional identification of dietary GPS supplementation and more fundamental information about how GPS promoted the immune response and healthy growth of the infant from mothers at molecular levels.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30407669</pmid><doi>10.1111/jpn.12993</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0274-2211</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animal Feed Animal Nutritional Physiological Phenomena Animals Diet Diet - veterinary Dietary Supplements esRNAs exosome Exosomes Exosomes - chemistry Functionals Gene expression Gene Expression Profiling Genes Ginseng Ginseng polysaccharide Immune response Immune system Immunoregulation Milk Milk - chemistry Milk - metabolism miRNA Panax - chemistry Polysaccharides Polysaccharides - chemistry Polysaccharides - pharmacology Proteins Ribonucleic acid RNA RNA - chemistry RNA - metabolism Saccharides sow Swine - immunology Swine - metabolism Transcriptome |
| title | The effect of dietary ginseng polysaccharide supplementation on porcine milk‐derived esRNAs involved in the host immune responses |
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