An Overview of 3D Printing Technologies for Soft Materials and Potential Opportunities for Lipid-based Drug Delivery Systems
Purpose Three-dimensional printing (3DP) is a rapidly growing additive manufacturing process and it is predicted that the technology will transform the production of goods across numerous fields. In the pharmaceutical sector, 3DP has been used to develop complex dosage forms of different sizes and s...
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| Veröffentlicht in: | Pharmaceutical research 2019-01, Vol.36 (1), p.4-20, Article 4 |
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| creator | Vithani, Kapilkumar Goyanes, Alvaro Jannin, Vincent Basit, Abdul W. Gaisford, Simon Boyd, Ben J. |
| description | Purpose
Three-dimensional printing (3DP) is a rapidly growing additive manufacturing process and it is predicted that the technology will transform the production of goods across numerous fields. In the pharmaceutical sector, 3DP has been used to develop complex dosage forms of different sizes and structures, dose variations, dose combinations and release characteristics, not possible to produce using traditional manufacturing methods. However, the technology has mainly been focused on polymer-based systems and currently, limited information is available about the potential opportunities for the 3DP of soft materials such as lipids.
Methods
This review paper emphasises the most commonly used 3DP technologies for soft materials such as inkjet printing, binder jetting, selective laser sintering (SLS), stereolithography (SLA), fused deposition modeling (FDM) and semi-solid extrusion, with the current status of these technologies for soft materials in biological, food and pharmaceutical applications.
Result
The advantages of 3DP, particularly in the pharmaceutical field, are highlighted and an insight is provided about the current studies for lipid-based drug delivery systems evaluating the potential of 3DP to fabricate innovative products. Additionally, the challenges of the 3DP technologies associated with technical processing, regulatory and material issues of lipids are discussed in detail.
Conclusion
The future utility of 3DP for printing soft materials, particularly for lipid-based drug delivery systems, offers great advantages and the technology will potentially support patient compliance and drug effectiveness via a personalised medicine approach. |
| doi_str_mv | 10.1007/s11095-018-2531-1 |
| format | Article |
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Three-dimensional printing (3DP) is a rapidly growing additive manufacturing process and it is predicted that the technology will transform the production of goods across numerous fields. In the pharmaceutical sector, 3DP has been used to develop complex dosage forms of different sizes and structures, dose variations, dose combinations and release characteristics, not possible to produce using traditional manufacturing methods. However, the technology has mainly been focused on polymer-based systems and currently, limited information is available about the potential opportunities for the 3DP of soft materials such as lipids.
Methods
This review paper emphasises the most commonly used 3DP technologies for soft materials such as inkjet printing, binder jetting, selective laser sintering (SLS), stereolithography (SLA), fused deposition modeling (FDM) and semi-solid extrusion, with the current status of these technologies for soft materials in biological, food and pharmaceutical applications.
Result
The advantages of 3DP, particularly in the pharmaceutical field, are highlighted and an insight is provided about the current studies for lipid-based drug delivery systems evaluating the potential of 3DP to fabricate innovative products. Additionally, the challenges of the 3DP technologies associated with technical processing, regulatory and material issues of lipids are discussed in detail.
Conclusion
The future utility of 3DP for printing soft materials, particularly for lipid-based drug delivery systems, offers great advantages and the technology will potentially support patient compliance and drug effectiveness via a personalised medicine approach.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1007/s11095-018-2531-1</identifier><identifier>PMID: 30406349</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>3D printing ; 3D Printing of Pharmaceutical and Medical Applications: A New Era ; Analysis ; Biochemistry ; Biological materials ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Drug delivery ; Drug delivery systems ; Drug Delivery Systems - methods ; Drug dosages ; Drugs ; Expert Review ; Humans ; Inkjet printing ; Innovations ; Laser sintering ; Levetiracetam ; Lipids ; Lipids - chemistry ; Lithography ; Manufacturing ; Medical Law ; Nanoparticles - chemistry ; Pharmaceuticals ; Pharmacology/Toxicology ; Pharmacy ; Polymers - chemistry ; Precision medicine ; Precision Medicine - methods ; Printing ; Printing, Three-Dimensional ; Production methods ; Rapid prototyping ; Systems analysis ; Technology ; Technology application ; Vehicles</subject><ispartof>Pharmaceutical research, 2019-01, Vol.36 (1), p.4-20, Article 4</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Pharmaceutical Research is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-b6deb724a3d20d99404886482414a2fe8605f66d47317f299f62ac079ac2a3a13</citedby><cites>FETCH-LOGICAL-c508t-b6deb724a3d20d99404886482414a2fe8605f66d47317f299f62ac079ac2a3a13</cites><orcidid>0000-0001-5434-590X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11095-018-2531-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11095-018-2531-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30406349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vithani, Kapilkumar</creatorcontrib><creatorcontrib>Goyanes, Alvaro</creatorcontrib><creatorcontrib>Jannin, Vincent</creatorcontrib><creatorcontrib>Basit, Abdul W.</creatorcontrib><creatorcontrib>Gaisford, Simon</creatorcontrib><creatorcontrib>Boyd, Ben J.</creatorcontrib><title>An Overview of 3D Printing Technologies for Soft Materials and Potential Opportunities for Lipid-based Drug Delivery Systems</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><addtitle>Pharm Res</addtitle><description>Purpose
Three-dimensional printing (3DP) is a rapidly growing additive manufacturing process and it is predicted that the technology will transform the production of goods across numerous fields. In the pharmaceutical sector, 3DP has been used to develop complex dosage forms of different sizes and structures, dose variations, dose combinations and release characteristics, not possible to produce using traditional manufacturing methods. However, the technology has mainly been focused on polymer-based systems and currently, limited information is available about the potential opportunities for the 3DP of soft materials such as lipids.
Methods
This review paper emphasises the most commonly used 3DP technologies for soft materials such as inkjet printing, binder jetting, selective laser sintering (SLS), stereolithography (SLA), fused deposition modeling (FDM) and semi-solid extrusion, with the current status of these technologies for soft materials in biological, food and pharmaceutical applications.
Result
The advantages of 3DP, particularly in the pharmaceutical field, are highlighted and an insight is provided about the current studies for lipid-based drug delivery systems evaluating the potential of 3DP to fabricate innovative products. Additionally, the challenges of the 3DP technologies associated with technical processing, regulatory and material issues of lipids are discussed in detail.
Conclusion
The future utility of 3DP for printing soft materials, particularly for lipid-based drug delivery systems, offers great advantages and the technology will potentially support patient compliance and drug effectiveness via a personalised medicine approach.</description><subject>3D printing</subject><subject>3D Printing of Pharmaceutical and Medical Applications: A New Era</subject><subject>Analysis</subject><subject>Biochemistry</subject><subject>Biological materials</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drug Delivery Systems - methods</subject><subject>Drug dosages</subject><subject>Drugs</subject><subject>Expert Review</subject><subject>Humans</subject><subject>Inkjet printing</subject><subject>Innovations</subject><subject>Laser sintering</subject><subject>Levetiracetam</subject><subject>Lipids</subject><subject>Lipids - chemistry</subject><subject>Lithography</subject><subject>Manufacturing</subject><subject>Medical Law</subject><subject>Nanoparticles - chemistry</subject><subject>Pharmaceuticals</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Polymers - chemistry</subject><subject>Precision medicine</subject><subject>Precision Medicine - methods</subject><subject>Printing</subject><subject>Printing, Three-Dimensional</subject><subject>Production methods</subject><subject>Rapid prototyping</subject><subject>Systems analysis</subject><subject>Technology</subject><subject>Technology application</subject><subject>Vehicles</subject><issn>0724-8741</issn><issn>1573-904X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUtr3DAUhU1paaZpf0A3RdBNN06vHn5oOWT6gikTSArdCY195SrYkivZKQP58ZGZpKGlRQuB9N1zz-Fk2WsKZxSgeh8pBVnkQOucFZzm9Em2okXFcwni-9NsBRUTeV0JepK9iPEaAGoqxfPshIOAkgu5ym7XjuxuMNxY_EW8IXxDLoJ1k3UducLmh_O97yxGYnwgl95M5KueMFjdR6JdSy78hInWPdmNow_T7Oz0gG_taNt8ryO2ZBPmjmywt2nXgVwe4oRDfJk9M0kIX93fp9m3jx-uzj_n292nL-frbd4UUE_5vmxxn6Jo3jJopRQg6roUNRNUaGawLqEwZdmKitPKMClNyXQDldQN01xTfpq9O-qOwf-cMU5qsLHBvtcO_RwVo5wyzlghE_r2L_Taz8EldwsFZZ2Wi0eq0z0q64yfgm4WUbVORhkFCkWizv5BpdPiYBvv0Nj0_scAPQ40wccY0Kgx2EGHg6KglsbVsXGVGldL42rJ9ube8LwfsP098VBxAtgRiOnLdRgeE_1f9Q7pWbO5</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Vithani, Kapilkumar</creator><creator>Goyanes, Alvaro</creator><creator>Jannin, Vincent</creator><creator>Basit, Abdul W.</creator><creator>Gaisford, Simon</creator><creator>Boyd, Ben J.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5434-590X</orcidid></search><sort><creationdate>20190101</creationdate><title>An Overview of 3D Printing Technologies for Soft Materials and Potential Opportunities for Lipid-based Drug Delivery Systems</title><author>Vithani, Kapilkumar ; 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Three-dimensional printing (3DP) is a rapidly growing additive manufacturing process and it is predicted that the technology will transform the production of goods across numerous fields. In the pharmaceutical sector, 3DP has been used to develop complex dosage forms of different sizes and structures, dose variations, dose combinations and release characteristics, not possible to produce using traditional manufacturing methods. However, the technology has mainly been focused on polymer-based systems and currently, limited information is available about the potential opportunities for the 3DP of soft materials such as lipids.
Methods
This review paper emphasises the most commonly used 3DP technologies for soft materials such as inkjet printing, binder jetting, selective laser sintering (SLS), stereolithography (SLA), fused deposition modeling (FDM) and semi-solid extrusion, with the current status of these technologies for soft materials in biological, food and pharmaceutical applications.
Result
The advantages of 3DP, particularly in the pharmaceutical field, are highlighted and an insight is provided about the current studies for lipid-based drug delivery systems evaluating the potential of 3DP to fabricate innovative products. Additionally, the challenges of the 3DP technologies associated with technical processing, regulatory and material issues of lipids are discussed in detail.
Conclusion
The future utility of 3DP for printing soft materials, particularly for lipid-based drug delivery systems, offers great advantages and the technology will potentially support patient compliance and drug effectiveness via a personalised medicine approach.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30406349</pmid><doi>10.1007/s11095-018-2531-1</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0001-5434-590X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals |
| subjects | 3D printing 3D Printing of Pharmaceutical and Medical Applications: A New Era Analysis Biochemistry Biological materials Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Drug delivery Drug delivery systems Drug Delivery Systems - methods Drug dosages Drugs Expert Review Humans Inkjet printing Innovations Laser sintering Levetiracetam Lipids Lipids - chemistry Lithography Manufacturing Medical Law Nanoparticles - chemistry Pharmaceuticals Pharmacology/Toxicology Pharmacy Polymers - chemistry Precision medicine Precision Medicine - methods Printing Printing, Three-Dimensional Production methods Rapid prototyping Systems analysis Technology Technology application Vehicles |
| title | An Overview of 3D Printing Technologies for Soft Materials and Potential Opportunities for Lipid-based Drug Delivery Systems |
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