Expression profile of skin papillomas with high cancer risk displays a unique genetic signature that clusters with squamous cell carcinomas and predicts risk for malignant conversion

Chemical induction of squamous tumors in the mouse skin induces multiple benign papillomas: high-frequency terminally benign low-risk papillomas and low-frequency high-risk papillomas, the putative precursor lesions to squamous cell carcinoma (SCC). We have compared the gene expression profile of tw...

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Veröffentlicht in:	Oncogene 2007-10, Vol.26 (48), p.6885-6895
Hauptverfasser:	Darwiche, N, Ryscavage, A, Perez-Lorenzo, R, Wright, L, Bae, D-S, Hennings, H, Yuspa, S H, Glick, A B
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene - toxicity Adaptive immunity Animals Apoptosis Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Cancer patients Carcinogens - toxicity Carcinoma, Squamous Cell - chemically induced Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Care and treatment Cell Biology Cell number Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic - chemically induced Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Development and progression DNA microarrays Female Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Genetic aspects Human Genetics Immune response Immunity, Cellular Immunohistochemistry Immunology Immunophenotyping Internal Medicine Keratin Lesions Lymphocytes T Medicine Medicine & Public Health Mice Mice, Inbred SENCAR Molecular and cellular biology Oligonucleotide Array Sequence Analysis Oncology original-article Papilloma Papilloma - chemically induced Papilloma - metabolism Papilloma - pathology Predictive Value of Tests Reverse Transcriptase Polymerase Chain Reaction Risk Factors RNA, Messenger - genetics RNA, Messenger - metabolism Skin Skin - metabolism Skin - pathology Skin cancer Skin Neoplasms - chemically induced Skin Neoplasms - metabolism Skin Neoplasms - pathology Squamous cell carcinoma Tetradecanoylphorbol Acetate - toxicity Tumors
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Zusammenfassung:	Chemical induction of squamous tumors in the mouse skin induces multiple benign papillomas: high-frequency terminally benign low-risk papillomas and low-frequency high-risk papillomas, the putative precursor lesions to squamous cell carcinoma (SCC). We have compared the gene expression profile of twenty different early low- and high-risk papillomas with normal skin and SCC. Unsupervised clustering of 514 differentially expressed genes ( P
ISSN:	0950-9232 1476-5594
DOI:	10.1038/sj.onc.1210491