Inhibition of Akt signaling by the lignan matairesinol sensitizes prostate cancer cells to TRAIL-induced apoptosis

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to be selectively pro-apoptotic in cancer cells, with minimal toxicity to normal tissues. Although this feature makes TRAIL a promising anticancer agent, not all cancer cell types are sensitive to TRAIL-induced apoptosis...

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Veröffentlicht in:	Oncogene 2010-02, Vol.29 (6), p.898-908
Hauptverfasser:	Peuhu, E, Rivero-Müller, A, Stykki, H, Torvaldson, E, Holmbom, T, Eklund, P, Unkila, M, Sjöholm, R, Eriksson, J E
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Androgens Androgens - metabolism Animals Antineoplastic Agents - pharmacology Antitumor agents Apoptosis Apoptosis - drug effects BH3 Interacting Domain Death Agonist Protein - metabolism Biological and medical sciences Cancer cells Cell Biology Cell Line, Tumor Cell physiology Cell Polarity - drug effects Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular signal transduction Ectopic expression Fundamental and applied biological sciences. Psychology Furans - pharmacology Gene Expression Regulation, Neoplastic - drug effects Genetics Gynecology. Andrology. Obstetrics Human Genetics Humans Internal Medicine Kinases Lignans - pharmacology Male Male genital diseases Matairesinol Medical sciences Medicine Medicine & Public Health Mitochondria - drug effects Mitochondria - metabolism Molecular and cellular biology Nephrology. Urinary tract diseases Oncology original-article Pharmacology Physiological aspects Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Signal transduction Signal Transduction - drug effects TNF-Related Apoptosis-Inducing Ligand - pharmacology Toxicity TRAIL protein Tumor cells Tumors Tumors of the urinary system Urinary tract. Prostate gland
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