Antioxidant effect of haptoglobin phenotypes against DNA damage induced by hydrogen peroxide in human leukocytes

Human haptoglobin is classified into three major phenotypes: Hp1-1, Hp2-1 and Hp2-2; there are two autosomal alleles Hp*1 and Hp*2, and the Hp*1 allele has two subtypes, Hp*1F and Hp*1S. Haptoglobin acts as an antioxidant, preventing hemoglobin-driven oxidative damage. We used the comet assay to exa...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Genetics and molecular research 2009, Vol.8 (1), p.284-290
Hauptverfasser:	Moreira, L R S, Miranda-Vilela, A L, Silva, I C R, Akimoto, A K, Klautau-Guimarães, M N, Grisolia, C K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antioxidants DNA Damage Female Haptoglobins - genetics Humans Hydrogen Peroxide - toxicity Leukocytes - drug effects Male Phenotype
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!