PEGylated PAMAM Dendrimer-Doxorubicin Conjugates: In Vitro Evaluation and In Vivo Tumor Accumulation

Purpose To investigate the effects of PEGylation degree and drug conjugation style on the in vitro and in vivo behavior of PEGylated polyamidoamine (PAMAM) dendrimers-based drug delivery system. Methods Doxorubicin (DOX) was conjugated to differently PEGylated PAMAM dendrimers by acid-sensitive cis-...

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Veröffentlicht in:	Pharmaceutical research 2010, Vol.27 (1), p.161-174
Hauptverfasser:	Zhu, Saijie, Hong, Minghuang, Zhang, Lihong, Tang, Guotao, Jiang, Yanyan, Pei, Yuanying
Format:	Artikel
Sprache:	eng
Schlagworte:	acid-sensitive linkage Adenosine Triphosphate - metabolism Animals Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Cell Line, Tumor Cell Survival - drug effects cellular uptake Dendrimers - administration & dosage Dendrimers - pharmacokinetics Dendrimers - pharmacology doxorubicin Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Doxorubicin - pharmacology Drug Carriers - administration & dosage Drug Carriers - pharmacokinetics Drug Carriers - pharmacology Drug Compounding - methods Drug delivery systems Drug Delivery Systems - methods Endocytosis - drug effects Female General pharmacology Humans Medical Law Medical sciences Mice Neoplasm Transplantation Ovarian Neoplasms - metabolism Pharmaceutical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy poly(amidoamine) dendrimer poly(ethylene glycol) Polyethylene glycol Polyethylene Glycols - administration & dosage Polyethylene Glycols - pharmacokinetics Polyethylene Glycols - pharmacology Research Paper Temperature Toxicity Tumors
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