Necuparanib, A Multitargeting Heparan Sulfate Mimetic, Targets Tumor and Stromal Compartments in Pancreatic Cancer

Pancreatic cancer has an abysmal 5-year survival rate of 8%, making it a deadly disease with a need for novel therapies. Here we describe a multitargeting heparin-based mimetic, necuparanib, and its antitumor activity in both and models of pancreatic cancer. Necuparanib reduced tumor cell proliferat...

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Veröffentlicht in:	Molecular cancer therapeutics 2019-02, Vol.18 (2), p.245-256
Hauptverfasser:	MacDonald, Amanda, Priess, Michelle, Curran, Jennifer, Guess, Jamey, Farutin, Victor, Oosterom, Ilse, Chu, Chia Lin, Cochran, Edward, Zhang, Lynn, Getchell, Kristen, Lolkema, Martijn, Schultes, Birgit C, Krause, Silva
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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