Survival Outcomes of Oversized Cardiac Allografts in Pediatric Patients—A Single-Center Experience in Taiwan
An oversized cardiac allograft may have a negative impact on survival outcomes according to previous studies; however, due to the shortage of pediatric donor hearts, the use of oversized cardiac allografts is sometimes inevitable. In this study, we reported the survival outcomes of pediatric patient...
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| Veröffentlicht in: | Transplantation proceedings 2018-11, Vol.50 (9), p.2747-2750 |
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| creator | Ting, M. Tsao, C.-I. Wang, C.-H. Chi, N.-H. Huang, S.-C. Chou, N.-K. Chen, Y.-S. Wang, S.-S. |
| description | An oversized cardiac allograft may have a negative impact on survival outcomes according to previous studies; however, due to the shortage of pediatric donor hearts, the use of oversized cardiac allografts is sometimes inevitable. In this study, we reported the survival outcomes of pediatric patients in relation with the donor-recipient weight ratio.
Twenty-eight children, aged 3 months to 17 years, with dilated cardiomyopathy underwent primary cardiac transplantation at the National Taiwan University Hospital between 1995 and 2012. We analyzed these patients according to the donor-recipient weight ratio: group 1 (n = 19) with donor-recipient weight ratio |
| doi_str_mv | 10.1016/j.transproceed.2018.02.195 |
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Twenty-eight children, aged 3 months to 17 years, with dilated cardiomyopathy underwent primary cardiac transplantation at the National Taiwan University Hospital between 1995 and 2012. We analyzed these patients according to the donor-recipient weight ratio: group 1 (n = 19) with donor-recipient weight ratio <2.5 (median 1.1, interquartile range 1.0–1.6), and group 2 (n = 9) with donor-recipient weight ratio ≥2.5 (median 3.0, inter-quartile range 2.87–3.5).
The 30-day survival rate was 100% for both group 1 and group 2 (P = 1). The survival rates for group 1 and group 2 were 95% vs 100% at 1 year, 84% vs 89% at 5 years, and 73% vs 61% at 10 years. The median survival was 14.4 years vs 12.9 years (P = .6313).
In this cohort, the use of oversized cardiac allograft in pediatric patients for dilated cardiomyopathy did not have a negative effect on short-term and long-term survival.
•Pediatric patients with dilated cardiomyopathy have enlarged pericardial cavity, so oversized cardiac allografts usually can fit the cavity.•“Big heart syndrome” occurred in about 20% of the pediatric patients receiving the oversized cardiac allograft.•The use of an oversized cardiac allograft (donor-recipient weight ratio ≥2.5) in pediatric patients for dilated cardiomyopathy did not have a negative effect on short-term and long-term survival in this cohort.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2018.02.195</identifier><identifier>PMID: 30401389</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Allografts - anatomy & histology ; Cardiomyopathy, Dilated - surgery ; Child ; Child, Preschool ; Cohort Studies ; Female ; Heart Transplantation - methods ; Heart Transplantation - mortality ; Humans ; Infant ; Male ; Reoperation ; Survival Rate ; Taiwan ; Tissue Donors</subject><ispartof>Transplantation proceedings, 2018-11, Vol.50 (9), p.2747-2750</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-9e162475a73ed5c1b3f8d87bdc3cfb11898ef3064c765aa9be7e17667945e3713</citedby><cites>FETCH-LOGICAL-c380t-9e162475a73ed5c1b3f8d87bdc3cfb11898ef3064c765aa9be7e17667945e3713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041134518304597$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30401389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ting, M.</creatorcontrib><creatorcontrib>Tsao, C.-I.</creatorcontrib><creatorcontrib>Wang, C.-H.</creatorcontrib><creatorcontrib>Chi, N.-H.</creatorcontrib><creatorcontrib>Huang, S.-C.</creatorcontrib><creatorcontrib>Chou, N.-K.</creatorcontrib><creatorcontrib>Chen, Y.-S.</creatorcontrib><creatorcontrib>Wang, S.-S.</creatorcontrib><title>Survival Outcomes of Oversized Cardiac Allografts in Pediatric Patients—A Single-Center Experience in Taiwan</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>An oversized cardiac allograft may have a negative impact on survival outcomes according to previous studies; however, due to the shortage of pediatric donor hearts, the use of oversized cardiac allografts is sometimes inevitable. In this study, we reported the survival outcomes of pediatric patients in relation with the donor-recipient weight ratio.
Twenty-eight children, aged 3 months to 17 years, with dilated cardiomyopathy underwent primary cardiac transplantation at the National Taiwan University Hospital between 1995 and 2012. We analyzed these patients according to the donor-recipient weight ratio: group 1 (n = 19) with donor-recipient weight ratio <2.5 (median 1.1, interquartile range 1.0–1.6), and group 2 (n = 9) with donor-recipient weight ratio ≥2.5 (median 3.0, inter-quartile range 2.87–3.5).
The 30-day survival rate was 100% for both group 1 and group 2 (P = 1). The survival rates for group 1 and group 2 were 95% vs 100% at 1 year, 84% vs 89% at 5 years, and 73% vs 61% at 10 years. The median survival was 14.4 years vs 12.9 years (P = .6313).
In this cohort, the use of oversized cardiac allograft in pediatric patients for dilated cardiomyopathy did not have a negative effect on short-term and long-term survival.
•Pediatric patients with dilated cardiomyopathy have enlarged pericardial cavity, so oversized cardiac allografts usually can fit the cavity.•“Big heart syndrome” occurred in about 20% of the pediatric patients receiving the oversized cardiac allograft.•The use of an oversized cardiac allograft (donor-recipient weight ratio ≥2.5) in pediatric patients for dilated cardiomyopathy did not have a negative effect on short-term and long-term survival in this cohort.</description><subject>Adolescent</subject><subject>Allografts - anatomy & histology</subject><subject>Cardiomyopathy, Dilated - surgery</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Heart Transplantation - methods</subject><subject>Heart Transplantation - mortality</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Reoperation</subject><subject>Survival Rate</subject><subject>Taiwan</subject><subject>Tissue Donors</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1u2zAQhYmiQe2mvUJBdNWNFI4oiVR3hps_IIADxFkTFDUyaMiSS1Ju0lUPkRPmJKVjB8gyq8HMvDcP8xHyHVgKDMqzdRqc7v3WDQaxSTMGMmVZClXxgUxBCp5kZcY_kiljOSTA82JCPnu_ZrHPcv6JTDjLGXBZTUl_N7qd3emOLsZghg16OrR0sUPn7V9s6Fy7xmpDZ103rJxug6e2p7cYh8FZQ291sNgH__zvaUbvbL_qMJnHATp6_rBFF5cG95altn90_4WctLrz-PVYT8n9xflyfpXcLC6v57ObxHDJQlIhlFkuCi04NoWBmreykaJuDDdtDSAriS1nZW5EWWhd1SgQRFmKKi-QC-Cn5MfhboT0e0Qf1MZ6g12nexxGrzLgTDIOJYvSnwepcYP3Dlu1dXaj3aMCpva81Vq95a32vBXLVOQdzd-OOWO9ibtX6yvgKPh1EGD8dmfRKW9emDTWoQmqGex7cv4DVSaabw</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Ting, M.</creator><creator>Tsao, C.-I.</creator><creator>Wang, C.-H.</creator><creator>Chi, N.-H.</creator><creator>Huang, S.-C.</creator><creator>Chou, N.-K.</creator><creator>Chen, Y.-S.</creator><creator>Wang, S.-S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201811</creationdate><title>Survival Outcomes of Oversized Cardiac Allografts in Pediatric Patients—A Single-Center Experience in Taiwan</title><author>Ting, M. ; Tsao, C.-I. ; Wang, C.-H. ; Chi, N.-H. ; Huang, S.-C. ; Chou, N.-K. ; Chen, Y.-S. ; Wang, S.-S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-9e162475a73ed5c1b3f8d87bdc3cfb11898ef3064c765aa9be7e17667945e3713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Allografts - anatomy & histology</topic><topic>Cardiomyopathy, Dilated - surgery</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Heart Transplantation - methods</topic><topic>Heart Transplantation - mortality</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Reoperation</topic><topic>Survival Rate</topic><topic>Taiwan</topic><topic>Tissue Donors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ting, M.</creatorcontrib><creatorcontrib>Tsao, C.-I.</creatorcontrib><creatorcontrib>Wang, C.-H.</creatorcontrib><creatorcontrib>Chi, N.-H.</creatorcontrib><creatorcontrib>Huang, S.-C.</creatorcontrib><creatorcontrib>Chou, N.-K.</creatorcontrib><creatorcontrib>Chen, Y.-S.</creatorcontrib><creatorcontrib>Wang, S.-S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ting, M.</au><au>Tsao, C.-I.</au><au>Wang, C.-H.</au><au>Chi, N.-H.</au><au>Huang, S.-C.</au><au>Chou, N.-K.</au><au>Chen, Y.-S.</au><au>Wang, S.-S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival Outcomes of Oversized Cardiac Allografts in Pediatric Patients—A Single-Center Experience in Taiwan</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2018-11</date><risdate>2018</risdate><volume>50</volume><issue>9</issue><spage>2747</spage><epage>2750</epage><pages>2747-2750</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><abstract>An oversized cardiac allograft may have a negative impact on survival outcomes according to previous studies; however, due to the shortage of pediatric donor hearts, the use of oversized cardiac allografts is sometimes inevitable. In this study, we reported the survival outcomes of pediatric patients in relation with the donor-recipient weight ratio.
Twenty-eight children, aged 3 months to 17 years, with dilated cardiomyopathy underwent primary cardiac transplantation at the National Taiwan University Hospital between 1995 and 2012. We analyzed these patients according to the donor-recipient weight ratio: group 1 (n = 19) with donor-recipient weight ratio <2.5 (median 1.1, interquartile range 1.0–1.6), and group 2 (n = 9) with donor-recipient weight ratio ≥2.5 (median 3.0, inter-quartile range 2.87–3.5).
The 30-day survival rate was 100% for both group 1 and group 2 (P = 1). The survival rates for group 1 and group 2 were 95% vs 100% at 1 year, 84% vs 89% at 5 years, and 73% vs 61% at 10 years. The median survival was 14.4 years vs 12.9 years (P = .6313).
In this cohort, the use of oversized cardiac allograft in pediatric patients for dilated cardiomyopathy did not have a negative effect on short-term and long-term survival.
•Pediatric patients with dilated cardiomyopathy have enlarged pericardial cavity, so oversized cardiac allografts usually can fit the cavity.•“Big heart syndrome” occurred in about 20% of the pediatric patients receiving the oversized cardiac allograft.•The use of an oversized cardiac allograft (donor-recipient weight ratio ≥2.5) in pediatric patients for dilated cardiomyopathy did not have a negative effect on short-term and long-term survival in this cohort.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30401389</pmid><doi>10.1016/j.transproceed.2018.02.195</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Allografts - anatomy & histology Cardiomyopathy, Dilated - surgery Child Child, Preschool Cohort Studies Female Heart Transplantation - methods Heart Transplantation - mortality Humans Infant Male Reoperation Survival Rate Taiwan Tissue Donors |
| title | Survival Outcomes of Oversized Cardiac Allografts in Pediatric Patients—A Single-Center Experience in Taiwan |
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