Expression patterns common and unique to ulcerative colitis and celiac disease
Autoimmune diseases like celiac disease (CeD) and ulcerative colitis (UC) show a common genetic background defined by the existence of shared susceptibility loci. We aimed to go deeper into this common genetic background through performing a cross‐disease study based on gene expression. We measured...
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| Veröffentlicht in: | Annals of human genetics 2019-03, Vol.83 (2), p.86-94 |
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| creator | Medrano, Luz María Pascual, Virginia Bodas, Andrés López‐Palacios, Natalia Salazar, Isabel Espino‐Paisán, Laura González‐Pérez, Beatriz Urcelay, Elena Mendoza, Juan Luis Núñez, Concepción |
| description | Autoimmune diseases like celiac disease (CeD) and ulcerative colitis (UC) show a common genetic background defined by the existence of shared susceptibility loci. We aimed to go deeper into this common genetic background through performing a cross‐disease study based on gene expression. We measured the expression of 21 genes located in 13 CeD‐UC susceptibility regions, and 10 genes in five CeD risk regions. Determinations were carried out in colon/rectum samples from 13 UC patients (inflamed and uninflamed tissue) and four colon samples from controls. Duodenal samples from 19 CeD patients and 12 controls were used for comparisons. Differences were analyzed using the Bayesian method. The shared chromosomal regions containing TNFAIP3, PTPN2, ICOSLG, C1orf106, and IL21 showed similar results in both diseases. FASLG, PLEK, CCR4, and TAGAP, all located in CeD risk loci, were up‐regulated in both CeD and UC patients. Finally, ZFP36L1, ZMIZ1, PUS10, UBE2L3, and BACH2 showed opposite results in CeD and UC. A high complexity underlies autoimmune common susceptibility loci, as the expression pattern of the studied genes does not always correlate with the one expected attending to the apparent genetic background. Differentially expressed genes such as ZFP36L1, ZMIZ1, PUS10, and BACH2 deserve further research in autoimmune diseases. |
| doi_str_mv | 10.1111/ahg.12293 |
| format | Article |
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We aimed to go deeper into this common genetic background through performing a cross‐disease study based on gene expression. We measured the expression of 21 genes located in 13 CeD‐UC susceptibility regions, and 10 genes in five CeD risk regions. Determinations were carried out in colon/rectum samples from 13 UC patients (inflamed and uninflamed tissue) and four colon samples from controls. Duodenal samples from 19 CeD patients and 12 controls were used for comparisons. Differences were analyzed using the Bayesian method. The shared chromosomal regions containing TNFAIP3, PTPN2, ICOSLG, C1orf106, and IL21 showed similar results in both diseases. FASLG, PLEK, CCR4, and TAGAP, all located in CeD risk loci, were up‐regulated in both CeD and UC patients. Finally, ZFP36L1, ZMIZ1, PUS10, UBE2L3, and BACH2 showed opposite results in CeD and UC. A high complexity underlies autoimmune common susceptibility loci, as the expression pattern of the studied genes does not always correlate with the one expected attending to the apparent genetic background. Differentially expressed genes such as ZFP36L1, ZMIZ1, PUS10, and BACH2 deserve further research in autoimmune diseases.</description><identifier>ISSN: 0003-4800</identifier><identifier>EISSN: 1469-1809</identifier><identifier>DOI: 10.1111/ahg.12293</identifier><identifier>PMID: 30402962</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; association signals ; Autoimmune diseases ; Bayes Theorem ; Bayesian analysis ; candidate genes ; Case-Control Studies ; Celiac disease ; Celiac Disease - genetics ; Colitis, Ulcerative - genetics ; Colon ; Disease ; disease susceptibility ; Gene expression ; Genetic Predisposition to Disease ; Humans ; Inflammation ; Inflammatory bowel disease ; Interleukin 21 ; PTPN2 protein ; Rectum ; Ulcerative colitis</subject><ispartof>Annals of human genetics, 2019-03, Vol.83 (2), p.86-94</ispartof><rights>2018 John Wiley & Sons Ltd/University College London</rights><rights>2018 John Wiley & Sons Ltd/University College London.</rights><rights>2019 John Wiley & Sons Ltd/University College London</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-bcaa8dfd0802e49be46db3dd54eab9aa2fbc46d704b0b8d6f370d175cf7acc153</citedby><cites>FETCH-LOGICAL-c3533-bcaa8dfd0802e49be46db3dd54eab9aa2fbc46d704b0b8d6f370d175cf7acc153</cites><orcidid>0000-0001-9136-4106</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fahg.12293$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fahg.12293$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30402962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Medrano, Luz María</creatorcontrib><creatorcontrib>Pascual, Virginia</creatorcontrib><creatorcontrib>Bodas, Andrés</creatorcontrib><creatorcontrib>López‐Palacios, Natalia</creatorcontrib><creatorcontrib>Salazar, Isabel</creatorcontrib><creatorcontrib>Espino‐Paisán, Laura</creatorcontrib><creatorcontrib>González‐Pérez, Beatriz</creatorcontrib><creatorcontrib>Urcelay, Elena</creatorcontrib><creatorcontrib>Mendoza, Juan Luis</creatorcontrib><creatorcontrib>Núñez, Concepción</creatorcontrib><title>Expression patterns common and unique to ulcerative colitis and celiac disease</title><title>Annals of human genetics</title><addtitle>Ann Hum Genet</addtitle><description>Autoimmune diseases like celiac disease (CeD) and ulcerative colitis (UC) show a common genetic background defined by the existence of shared susceptibility loci. We aimed to go deeper into this common genetic background through performing a cross‐disease study based on gene expression. We measured the expression of 21 genes located in 13 CeD‐UC susceptibility regions, and 10 genes in five CeD risk regions. Determinations were carried out in colon/rectum samples from 13 UC patients (inflamed and uninflamed tissue) and four colon samples from controls. Duodenal samples from 19 CeD patients and 12 controls were used for comparisons. Differences were analyzed using the Bayesian method. The shared chromosomal regions containing TNFAIP3, PTPN2, ICOSLG, C1orf106, and IL21 showed similar results in both diseases. FASLG, PLEK, CCR4, and TAGAP, all located in CeD risk loci, were up‐regulated in both CeD and UC patients. Finally, ZFP36L1, ZMIZ1, PUS10, UBE2L3, and BACH2 showed opposite results in CeD and UC. A high complexity underlies autoimmune common susceptibility loci, as the expression pattern of the studied genes does not always correlate with the one expected attending to the apparent genetic background. Differentially expressed genes such as ZFP36L1, ZMIZ1, PUS10, and BACH2 deserve further research in autoimmune diseases.</description><subject>Adult</subject><subject>association signals</subject><subject>Autoimmune diseases</subject><subject>Bayes Theorem</subject><subject>Bayesian analysis</subject><subject>candidate genes</subject><subject>Case-Control Studies</subject><subject>Celiac disease</subject><subject>Celiac Disease - genetics</subject><subject>Colitis, Ulcerative - genetics</subject><subject>Colon</subject><subject>Disease</subject><subject>disease susceptibility</subject><subject>Gene expression</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammatory bowel disease</subject><subject>Interleukin 21</subject><subject>PTPN2 protein</subject><subject>Rectum</subject><subject>Ulcerative colitis</subject><issn>0003-4800</issn><issn>1469-1809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKAzEUhoMotlYXvoAMuNHFtCeXuS1Lqa0gutF1yCQZTZmbyYzatzftVBeCZxPOycfHz4_QJYYp9jMTb69TTEhGj9AYszgLcQrZMRoDAA1ZCjBCZ85tADBJGT1FIwoMSBaTMXpcfrVWO2eaOmhF12lbu0A2VeV3Uaugr817r4OuCfpSais686H9f2k64_aA1KURMlDGaeH0OTopROn0xeGdoJe75fNiHT48re4X84dQ0ojSMJdCpKpQkALRLMs1i1VOlYqYFnkmBCly6U8JsBzyVMUFTUDhJJJFIqTEEZ2gm8Hb2sbncx2vjPNRSlHrpnecYOrdGMgOvf6Dbpre1j6dp5I4JjiLU0_dDpS0jXNWF7y1phJ2yzHwXcncl8z3JXv26mDs80qrX_KnVQ_MBuDTlHr7v4nP16tB-Q0zCYZ0</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Medrano, Luz María</creator><creator>Pascual, Virginia</creator><creator>Bodas, Andrés</creator><creator>López‐Palacios, Natalia</creator><creator>Salazar, Isabel</creator><creator>Espino‐Paisán, Laura</creator><creator>González‐Pérez, Beatriz</creator><creator>Urcelay, Elena</creator><creator>Mendoza, Juan Luis</creator><creator>Núñez, Concepción</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9136-4106</orcidid></search><sort><creationdate>201903</creationdate><title>Expression patterns common and unique to ulcerative colitis and celiac disease</title><author>Medrano, Luz María ; Pascual, Virginia ; Bodas, Andrés ; López‐Palacios, Natalia ; Salazar, Isabel ; Espino‐Paisán, Laura ; González‐Pérez, Beatriz ; Urcelay, Elena ; Mendoza, Juan Luis ; Núñez, Concepción</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-bcaa8dfd0802e49be46db3dd54eab9aa2fbc46d704b0b8d6f370d175cf7acc153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>association signals</topic><topic>Autoimmune diseases</topic><topic>Bayes Theorem</topic><topic>Bayesian analysis</topic><topic>candidate genes</topic><topic>Case-Control Studies</topic><topic>Celiac disease</topic><topic>Celiac Disease - genetics</topic><topic>Colitis, Ulcerative - genetics</topic><topic>Colon</topic><topic>Disease</topic><topic>disease susceptibility</topic><topic>Gene expression</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammatory bowel disease</topic><topic>Interleukin 21</topic><topic>PTPN2 protein</topic><topic>Rectum</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Medrano, Luz María</creatorcontrib><creatorcontrib>Pascual, Virginia</creatorcontrib><creatorcontrib>Bodas, Andrés</creatorcontrib><creatorcontrib>López‐Palacios, Natalia</creatorcontrib><creatorcontrib>Salazar, Isabel</creatorcontrib><creatorcontrib>Espino‐Paisán, Laura</creatorcontrib><creatorcontrib>González‐Pérez, Beatriz</creatorcontrib><creatorcontrib>Urcelay, Elena</creatorcontrib><creatorcontrib>Mendoza, Juan Luis</creatorcontrib><creatorcontrib>Núñez, Concepción</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Medrano, Luz María</au><au>Pascual, Virginia</au><au>Bodas, Andrés</au><au>López‐Palacios, Natalia</au><au>Salazar, Isabel</au><au>Espino‐Paisán, Laura</au><au>González‐Pérez, Beatriz</au><au>Urcelay, Elena</au><au>Mendoza, Juan Luis</au><au>Núñez, Concepción</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression patterns common and unique to ulcerative colitis and celiac disease</atitle><jtitle>Annals of human genetics</jtitle><addtitle>Ann Hum Genet</addtitle><date>2019-03</date><risdate>2019</risdate><volume>83</volume><issue>2</issue><spage>86</spage><epage>94</epage><pages>86-94</pages><issn>0003-4800</issn><eissn>1469-1809</eissn><abstract>Autoimmune diseases like celiac disease (CeD) and ulcerative colitis (UC) show a common genetic background defined by the existence of shared susceptibility loci. We aimed to go deeper into this common genetic background through performing a cross‐disease study based on gene expression. We measured the expression of 21 genes located in 13 CeD‐UC susceptibility regions, and 10 genes in five CeD risk regions. Determinations were carried out in colon/rectum samples from 13 UC patients (inflamed and uninflamed tissue) and four colon samples from controls. Duodenal samples from 19 CeD patients and 12 controls were used for comparisons. Differences were analyzed using the Bayesian method. The shared chromosomal regions containing TNFAIP3, PTPN2, ICOSLG, C1orf106, and IL21 showed similar results in both diseases. FASLG, PLEK, CCR4, and TAGAP, all located in CeD risk loci, were up‐regulated in both CeD and UC patients. Finally, ZFP36L1, ZMIZ1, PUS10, UBE2L3, and BACH2 showed opposite results in CeD and UC. A high complexity underlies autoimmune common susceptibility loci, as the expression pattern of the studied genes does not always correlate with the one expected attending to the apparent genetic background. Differentially expressed genes such as ZFP36L1, ZMIZ1, PUS10, and BACH2 deserve further research in autoimmune diseases.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30402962</pmid><doi>10.1111/ahg.12293</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9136-4106</orcidid></addata></record> |
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| subjects | Adult association signals Autoimmune diseases Bayes Theorem Bayesian analysis candidate genes Case-Control Studies Celiac disease Celiac Disease - genetics Colitis, Ulcerative - genetics Colon Disease disease susceptibility Gene expression Genetic Predisposition to Disease Humans Inflammation Inflammatory bowel disease Interleukin 21 PTPN2 protein Rectum Ulcerative colitis |
| title | Expression patterns common and unique to ulcerative colitis and celiac disease |
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