Molecular determinants of Akt-induced keratinocyte transformation

The PI3K/PTEN/Akt signaling pathway has emerged in recent years as a main player in human cancers, increasing proliferation and decreasing apoptosis of transformed cells, and thus becoming a potential target for therapeutic intervention. Our previous data have demonstrated that Akt-mediated signalin...

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Veröffentlicht in:	Oncogene 2006-02, Vol.25 (8), p.1174-1185
Hauptverfasser:	Segrelles, C, Moral, M, Lara, M Fernanda, Ruiz, S, Santos, M, Leis, H, García-Escudero, R, Martínez-Cruz, A B, Martínez-Palacio, J, Hernández, P, Ballestín, C, Paramio, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Analysis Animals Apoptosis beta Catenin - metabolism Biological and medical sciences c-Myc protein Cancer Carcinogenesis Cell Biology Cell physiology Cell Proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic Cells, Cultured Cyclin D1 - metabolism Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin-dependent kinase inhibitor p27 Cyclin-Dependent Kinase Inhibitor p27 - metabolism Development and progression Female Forkhead Box Protein O3 Forkhead Transcription Factors - metabolism FOXO3 protein Fundamental and applied biological sciences. Psychology Head and neck carcinoma Health aspects Human Genetics Immunohistochemistry Injections, Subcutaneous Internal Medicine Keratinocytes Keratinocytes - metabolism Keratinocytes - pathology Kinases Localization Lymphoid Enhancer-Binding Factor 1 - metabolism MDM2 protein Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Nude Molecular and cellular biology Molecular biology Myc protein Oncology original-article Phosphoproteins - metabolism Phosphorylation Post-transcription Protein Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-mdm2 - metabolism Proto-Oncogene Proteins c-myc - metabolism PTEN protein Signal Transduction Skin Skin Neoplasms - metabolism Squamous cell carcinoma TOR protein TOR Serine-Threonine Kinases Trans-Activators - metabolism Transformed cells Tumorigenesis Tumors
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