Are naïve T cells and class-switched memory (IgD− CD27+) B cells not essential for establishment and maintenance of pregnancy? Insights from a case of common variable immunodeficiency with pregnancy
The disruption of adaptive immune response has adverse effects on the establishment and maintenance of pregnancy. The adaptive immune system is regulated by several types of immune cells. However, there is limited information about cell hierarchy in the adaptive immune response to the establishment...
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| Veröffentlicht in: | Medical hypotheses 2018-12, Vol.121, p.36-41 |
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| creator | Shigeta, Naoya Nakamura, Hitomi Kumasawa, Keiichi Imai, Kohsuke Saito, Shigeru Sakaguchi, Shimon Kimura, Tadashi |
| description | The disruption of adaptive immune response has adverse effects on the establishment and maintenance of pregnancy. The adaptive immune system is regulated by several types of immune cells. However, there is limited information about cell hierarchy in the adaptive immune response to the establishment and maintenance of pregnancy in women. The assessment of the outcome of pregnancy in primary immunodeficiency diseases could help in understanding the cell hierarchy in the adaptive immune system during pregnancy. Common variable immunodeficiency (CVID) is a heterogeneous adaptive immune system disorder characterized by primary hypogammaglobulinemia. A few studies have previously reported the assessment of the T and B cell subpopulations in CVID patients. However, an assessment of the subpopulations of T and B cells and the outcome of pregnancy in women with CVID has not been reported till date. Most CVID patients show a general decrease in the expression of CD27 in B cells. The assessment of pregnancy and the subpopulations of T and B cells in CVID women with severe reduction in the naïve T and switched B cells could help understand whether these cells are essential for the establishment and maintenance of pregnancy in women. |
| doi_str_mv | 10.1016/j.mehy.2018.09.014 |
| format | Article |
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Insights from a case of common variable immunodeficiency with pregnancy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Shigeta, Naoya ; Nakamura, Hitomi ; Kumasawa, Keiichi ; Imai, Kohsuke ; Saito, Shigeru ; Sakaguchi, Shimon ; Kimura, Tadashi</creator><creatorcontrib>Shigeta, Naoya ; Nakamura, Hitomi ; Kumasawa, Keiichi ; Imai, Kohsuke ; Saito, Shigeru ; Sakaguchi, Shimon ; Kimura, Tadashi</creatorcontrib><description>The disruption of adaptive immune response has adverse effects on the establishment and maintenance of pregnancy. The adaptive immune system is regulated by several types of immune cells. However, there is limited information about cell hierarchy in the adaptive immune response to the establishment and maintenance of pregnancy in women. The assessment of the outcome of pregnancy in primary immunodeficiency diseases could help in understanding the cell hierarchy in the adaptive immune system during pregnancy. Common variable immunodeficiency (CVID) is a heterogeneous adaptive immune system disorder characterized by primary hypogammaglobulinemia. A few studies have previously reported the assessment of the T and B cell subpopulations in CVID patients. However, an assessment of the subpopulations of T and B cells and the outcome of pregnancy in women with CVID has not been reported till date. Most CVID patients show a general decrease in the expression of CD27 in B cells. 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However, an assessment of the subpopulations of T and B cells and the outcome of pregnancy in women with CVID has not been reported till date. Most CVID patients show a general decrease in the expression of CD27 in B cells. The assessment of pregnancy and the subpopulations of T and B cells in CVID women with severe reduction in the naïve T and switched B cells could help understand whether these cells are essential for the establishment and maintenance of pregnancy in women.</description><subject>Adaptive immune system</subject><subject>Adult</subject><subject>Agammaglobulinemia - immunology</subject><subject>B-Lymphocytes - classification</subject><subject>B-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Common variable immunodeficiency (CVID)</subject><subject>Common Variable Immunodeficiency - immunology</subject><subject>Female</subject><subject>Fetal Blood - immunology</subject><subject>Humans</subject><subject>Immunoglobulin Class Switching</subject><subject>Immunoglobulin D - immunology</subject><subject>Immunologic Memory</subject><subject>Infertility</subject><subject>Infertility, Female - immunology</subject><subject>Naïve T cell</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><subject>Pregnancy Outcome</subject><subject>Switched memory B cell</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes, Regulatory - cytology</subject><subject>Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology</subject><issn>0306-9877</issn><issn>1532-2777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2O0zAUhS0EYsrAC7BAXg5CCXbcJrGEhIYOP5VGYjOsLf_cNK5iu9hpUd-ANS_CQ7DiNXgSnLbAjpV1rXOO7v0OQk8pKSmh9ctN6aA_lBWhbUl4Sej8HprRBauKqmma-2hGGKkL3jbNBXqU0oYQwuesfYguGGG8nrfzGfp5HQF7-eP7HvAd1jAMCUtvsB5kSkX6Ykfdg8EOXIgHfLVa3_z6-g0vb6rmxXP85mzwYcSQEvjRygF3IeZplGqwqXf58xjopPUjeOk14NDhbYT1NBxe45VPdt2PCXcxOCyxluko0cG54PFeRpuzAFvndj4Y6Ky2kJ04L9f_C3qMHnRySPDk_F6iT-_e3i0_FLcf36-W17eFrho6Fm3bkk7LRWUyAqmAUVZ3jVEqsyILUMbUShPFMzvOWNNqVfOFqlnHOZi2UuwSXZ1ytzF83uVDhbNp4iA9hF0SFWUT94bQLK1OUh1DShE6sY3WyXgQlIipQrERU4ViqlAQLnKF2fTsnL9TDsxfy5_OsuDVSQD5yr2FKNIRCBgbQY_CBPu__N-ANrH1</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Shigeta, Naoya</creator><creator>Nakamura, Hitomi</creator><creator>Kumasawa, Keiichi</creator><creator>Imai, Kohsuke</creator><creator>Saito, Shigeru</creator><creator>Sakaguchi, Shimon</creator><creator>Kimura, Tadashi</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2132-8403</orcidid></search><sort><creationdate>201812</creationdate><title>Are naïve T cells and class-switched memory (IgD− CD27+) B cells not essential for establishment and maintenance of pregnancy? Insights from a case of common variable immunodeficiency with pregnancy</title><author>Shigeta, Naoya ; Nakamura, Hitomi ; Kumasawa, Keiichi ; Imai, Kohsuke ; Saito, Shigeru ; Sakaguchi, Shimon ; Kimura, Tadashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c271t-8880fca52d396abe3136f7dbb30605ebdd6bc0b903093378cb695b63f99ed82b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adaptive immune system</topic><topic>Adult</topic><topic>Agammaglobulinemia - immunology</topic><topic>B-Lymphocytes - classification</topic><topic>B-Lymphocytes - immunology</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Common variable immunodeficiency (CVID)</topic><topic>Common Variable Immunodeficiency - immunology</topic><topic>Female</topic><topic>Fetal Blood - immunology</topic><topic>Humans</topic><topic>Immunoglobulin Class Switching</topic><topic>Immunoglobulin D - immunology</topic><topic>Immunologic Memory</topic><topic>Infertility</topic><topic>Infertility, Female - immunology</topic><topic>Naïve T cell</topic><topic>Pregnancy</topic><topic>Pregnancy Complications</topic><topic>Pregnancy Outcome</topic><topic>Switched memory B cell</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes, Regulatory - cytology</topic><topic>Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shigeta, Naoya</creatorcontrib><creatorcontrib>Nakamura, Hitomi</creatorcontrib><creatorcontrib>Kumasawa, Keiichi</creatorcontrib><creatorcontrib>Imai, Kohsuke</creatorcontrib><creatorcontrib>Saito, Shigeru</creatorcontrib><creatorcontrib>Sakaguchi, Shimon</creatorcontrib><creatorcontrib>Kimura, Tadashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical hypotheses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shigeta, Naoya</au><au>Nakamura, Hitomi</au><au>Kumasawa, Keiichi</au><au>Imai, Kohsuke</au><au>Saito, Shigeru</au><au>Sakaguchi, Shimon</au><au>Kimura, Tadashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are naïve T cells and class-switched memory (IgD− CD27+) B cells not essential for establishment and maintenance of pregnancy? 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A few studies have previously reported the assessment of the T and B cell subpopulations in CVID patients. However, an assessment of the subpopulations of T and B cells and the outcome of pregnancy in women with CVID has not been reported till date. Most CVID patients show a general decrease in the expression of CD27 in B cells. The assessment of pregnancy and the subpopulations of T and B cells in CVID women with severe reduction in the naïve T and switched B cells could help understand whether these cells are essential for the establishment and maintenance of pregnancy in women.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>30396484</pmid><doi>10.1016/j.mehy.2018.09.014</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-2132-8403</orcidid></addata></record> |
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| subjects | Adaptive immune system Adult Agammaglobulinemia - immunology B-Lymphocytes - classification B-Lymphocytes - immunology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Common variable immunodeficiency (CVID) Common Variable Immunodeficiency - immunology Female Fetal Blood - immunology Humans Immunoglobulin Class Switching Immunoglobulin D - immunology Immunologic Memory Infertility Infertility, Female - immunology Naïve T cell Pregnancy Pregnancy Complications Pregnancy Outcome Switched memory B cell T-Lymphocytes - immunology T-Lymphocytes, Regulatory - cytology Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology |
| title | Are naïve T cells and class-switched memory (IgD− CD27+) B cells not essential for establishment and maintenance of pregnancy? Insights from a case of common variable immunodeficiency with pregnancy |
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