Targeting an Autocrine Regulatory Loop in Cancer Stem-like Cells Impairs the Progression and Chemotherapy Resistance of Bladder Cancer

Cancer stem-like cells (CSCs) contribute to bladder cancer chemotherapy resistance and progression, but the associated mechanisms have not been elucidated. This study determined whether blocking an autocrine signaling loop in CSCs improves the therapeutic effects of -platinum on bladder cancer. The...

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Veröffentlicht in:	Clinical cancer research 2019-02, Vol.25 (3), p.1070-1086
Hauptverfasser:	Wang, Kai-Jian, Wang, Chao, Dai, Li-He, Yang, Jun, Huang, Hai, Ma, Xiao-Jing, Zhou, Zhe, Yang, Ze-Yu, Xu, Wei-Dong, Hua, Mei-Mian, Lu, Xin, Zeng, Shu-Xiong, Wang, Hui-Qing, Zhang, Zhen-Sheng, Cheng, Yan-Qiong, Liu, Dan, Tian, Qin-Qin, Sun, Ying-Hao, Xu, Chuan-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - antagonists & inhibitors Adaptor Proteins, Signal Transducing - metabolism Animals Autocrine Communication - genetics Benzimidazoles - pharmacology Cell Line, Tumor Cisplatin - pharmacology Disease Progression Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic Humans Male Mice, Inbred NOD Mice, SCID Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Quinolines - pharmacology Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors Receptors, Platelet-Derived Growth Factor - metabolism Transcription Factors - antagonists & inhibitors Transcription Factors - metabolism Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology Verteporfin - pharmacology Xenograft Model Antitumor Assays - methods
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