How to safeguard an appropriate “all trans retinoic acid” concentration to keep cell division on track: Exploring therapeutic hotspots from metabolomics

In this letter to editor, I hypothesize a potential affinity of retinol saturase (RetSat) enzyme towards a conjugated trienoic fatty acid; alpha-eleostearic acid (α-ESA) and subsequent hindrance of the action on its usual substrate; all trans retinol. Hence, RetSat is speculated to be involved in a...

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Veröffentlicht in:	Medical hypotheses 2018-12, Vol.121, p.56-56
1. Verfasser:	Jayasooriya, Anura P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - drug effects Cell Division Humans Linoleic Acid - chemistry Linoleic Acids, Conjugated - chemistry Linolenic Acids - chemistry Lipid Metabolism Metabolomics Neoplasms - therapy Tretinoin - metabolism Tretinoin - pharmacology Vitamin A - metabolism
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