Materials Science and Design Principles of Growth Factor Delivery Systems in Tissue Engineering and Regenerative Medicine
Growth factors (GFs) are signaling molecules that direct cell development by providing biochemical cues for stem cell proliferation, migration, and differentiation. GFs play a key role in tissue regeneration, but one major limitation of GF‐based therapies is dosage‐related adverse effects. Additiona...
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| Veröffentlicht in: | Advanced healthcare materials 2019-01, Vol.8 (1), p.e1801000-n/a |
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| description | Growth factors (GFs) are signaling molecules that direct cell development by providing biochemical cues for stem cell proliferation, migration, and differentiation. GFs play a key role in tissue regeneration, but one major limitation of GF‐based therapies is dosage‐related adverse effects. Additionally, the clinical applications and efficacy of GFs are significantly affected by the efficiency of delivery systems and other pharmacokinetic factors. Hence, it is crucial to design delivery systems that provide optimal activity, stability, and tunable delivery for GFs. Understanding the physicochemical properties of the GFs and the biomaterials utilized for the development of biomimetic GF delivery systems is critical for GF‐based regeneration. Many different delivery systems have been developed to achieve tunable delivery kinetics for single or multiple GFs. The identification of ideal biomaterials with tunable properties for spatiotemporal delivery of GFs is still challenging. This review characterizes the types, properties, and functions of GFs, the materials science of widely used biomaterials, and various GF loading strategies to comprehensively summarize the current delivery systems for tunable spatiotemporal delivery of GFs aimed for tissue regeneration applications. This review concludes by discussing fundamental design principles for GF delivery vehicles based on the interactive physicochemical properties of the proteins and biomaterials.
Growth factor delivery is emerging as a potential alternative for healing severely injured complex tissues. Engineering delivery system with increased payloads and tunable release kinetics remains challenging in the realm of translational research. This review discusses the complexities behind growth factors and biomaterials to advance the development of modern delivery systems to meet the current challenges for effective tissue repair. |
| doi_str_mv | 10.1002/adhm.201801000 |
| format | Article |
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Growth factor delivery is emerging as a potential alternative for healing severely injured complex tissues. Engineering delivery system with increased payloads and tunable release kinetics remains challenging in the realm of translational research. This review discusses the complexities behind growth factors and biomaterials to advance the development of modern delivery systems to meet the current challenges for effective tissue repair.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.201801000</identifier><identifier>PMID: 30398700</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Animals ; Biocompatible Materials - chemistry ; Biomaterials ; Biomedical materials ; Biomimetics ; Cell migration ; Cell proliferation ; delivery systems ; Design ; Design engineering ; Drug Delivery Systems ; Growth factors ; Humans ; Intercellular Signaling Peptides and Proteins - administration & dosage ; Intercellular Signaling Peptides and Proteins - therapeutic use ; Kinetics ; loading strategies ; Materials Science ; Pharmacology ; Physicochemical properties ; Properties (attributes) ; Proteins ; Regeneration ; Regeneration (physiology) ; Regenerative Medicine ; release kinetics ; Stem cells ; Therapeutic applications ; Tissue Engineering ; tissue engineering and regenerative medicine</subject><ispartof>Advanced healthcare materials, 2019-01, Vol.8 (1), p.e1801000-n/a</ispartof><rights>2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4500-62ddb5b6a05c29065252929def5b8816833f4b3e102d51feee80ed4bf9cbf6fe3</citedby><cites>FETCH-LOGICAL-c4500-62ddb5b6a05c29065252929def5b8816833f4b3e102d51feee80ed4bf9cbf6fe3</cites><orcidid>0000-0003-0044-9740</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.201801000$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.201801000$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30398700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Subbiah, Ramesh</creatorcontrib><creatorcontrib>Guldberg, Robert E.</creatorcontrib><title>Materials Science and Design Principles of Growth Factor Delivery Systems in Tissue Engineering and Regenerative Medicine</title><title>Advanced healthcare materials</title><addtitle>Adv Healthc Mater</addtitle><description>Growth factors (GFs) are signaling molecules that direct cell development by providing biochemical cues for stem cell proliferation, migration, and differentiation. GFs play a key role in tissue regeneration, but one major limitation of GF‐based therapies is dosage‐related adverse effects. Additionally, the clinical applications and efficacy of GFs are significantly affected by the efficiency of delivery systems and other pharmacokinetic factors. Hence, it is crucial to design delivery systems that provide optimal activity, stability, and tunable delivery for GFs. Understanding the physicochemical properties of the GFs and the biomaterials utilized for the development of biomimetic GF delivery systems is critical for GF‐based regeneration. Many different delivery systems have been developed to achieve tunable delivery kinetics for single or multiple GFs. The identification of ideal biomaterials with tunable properties for spatiotemporal delivery of GFs is still challenging. This review characterizes the types, properties, and functions of GFs, the materials science of widely used biomaterials, and various GF loading strategies to comprehensively summarize the current delivery systems for tunable spatiotemporal delivery of GFs aimed for tissue regeneration applications. This review concludes by discussing fundamental design principles for GF delivery vehicles based on the interactive physicochemical properties of the proteins and biomaterials.
Growth factor delivery is emerging as a potential alternative for healing severely injured complex tissues. Engineering delivery system with increased payloads and tunable release kinetics remains challenging in the realm of translational research. This review discusses the complexities behind growth factors and biomaterials to advance the development of modern delivery systems to meet the current challenges for effective tissue repair.</description><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Biomimetics</subject><subject>Cell migration</subject><subject>Cell proliferation</subject><subject>delivery systems</subject><subject>Design</subject><subject>Design engineering</subject><subject>Drug Delivery Systems</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - administration & dosage</subject><subject>Intercellular Signaling Peptides and Proteins - therapeutic use</subject><subject>Kinetics</subject><subject>loading strategies</subject><subject>Materials Science</subject><subject>Pharmacology</subject><subject>Physicochemical properties</subject><subject>Properties (attributes)</subject><subject>Proteins</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Regenerative Medicine</subject><subject>release kinetics</subject><subject>Stem cells</subject><subject>Therapeutic applications</subject><subject>Tissue Engineering</subject><subject>tissue engineering and regenerative medicine</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtP3DAURq0KVNDAtsvKUjdsZrh24mAvEc9KjKgKXUeOfT0YJc5gJ6D8-xoGphKbbvyQzz329UfINwYLBsCPtX3oFhyYhLyFL2SfM8XnvBJqZ7suYY8cpvSYAagEqyT7SvYKKJQ8Adgn01IPGL1uE70zHoNBqoOl55j8KtBf0Qfj1y0m2jt6FfuX4YFeajP0MSOtf8Y40bspDdgl6gO99ymNSC_CygfM2rB6s_3GFQaMesgFdInWm3x8QHZdvhYP3-cZ-XN5cX92Pb-5vfp5dnozN6UAmFfc2kY0lQZhuMotcMEVVxadaKTM_RSFK5sCGXArmENECWjLxinTuMphMSNHG-869k8jpqHufDLYtjpgP6aas_wbUEp5ktEfn9DHfowhvy5TlZAFqDzMyGJDmdinFNHV6-g7HaeaQf2aS_2aS73NJRd8f9eOTYd2i3-kkAG1AV58i9N_dPXp-fXyn_wvLkmZ4A</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Subbiah, Ramesh</creator><creator>Guldberg, Robert E.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0044-9740</orcidid></search><sort><creationdate>201901</creationdate><title>Materials Science and Design Principles of Growth Factor Delivery Systems in Tissue Engineering and Regenerative Medicine</title><author>Subbiah, Ramesh ; Guldberg, Robert E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4500-62ddb5b6a05c29065252929def5b8816833f4b3e102d51feee80ed4bf9cbf6fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biomaterials</topic><topic>Biomedical materials</topic><topic>Biomimetics</topic><topic>Cell migration</topic><topic>Cell proliferation</topic><topic>delivery systems</topic><topic>Design</topic><topic>Design engineering</topic><topic>Drug Delivery Systems</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - administration & dosage</topic><topic>Intercellular Signaling Peptides and Proteins - therapeutic use</topic><topic>Kinetics</topic><topic>loading strategies</topic><topic>Materials Science</topic><topic>Pharmacology</topic><topic>Physicochemical properties</topic><topic>Properties (attributes)</topic><topic>Proteins</topic><topic>Regeneration</topic><topic>Regeneration (physiology)</topic><topic>Regenerative Medicine</topic><topic>release kinetics</topic><topic>Stem cells</topic><topic>Therapeutic applications</topic><topic>Tissue Engineering</topic><topic>tissue engineering and regenerative medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Subbiah, Ramesh</creatorcontrib><creatorcontrib>Guldberg, Robert E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Immunology Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced healthcare materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Subbiah, Ramesh</au><au>Guldberg, Robert E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Materials Science and Design Principles of Growth Factor Delivery Systems in Tissue Engineering and Regenerative Medicine</atitle><jtitle>Advanced healthcare materials</jtitle><addtitle>Adv Healthc Mater</addtitle><date>2019-01</date><risdate>2019</risdate><volume>8</volume><issue>1</issue><spage>e1801000</spage><epage>n/a</epage><pages>e1801000-n/a</pages><issn>2192-2640</issn><eissn>2192-2659</eissn><abstract>Growth factors (GFs) are signaling molecules that direct cell development by providing biochemical cues for stem cell proliferation, migration, and differentiation. GFs play a key role in tissue regeneration, but one major limitation of GF‐based therapies is dosage‐related adverse effects. Additionally, the clinical applications and efficacy of GFs are significantly affected by the efficiency of delivery systems and other pharmacokinetic factors. Hence, it is crucial to design delivery systems that provide optimal activity, stability, and tunable delivery for GFs. Understanding the physicochemical properties of the GFs and the biomaterials utilized for the development of biomimetic GF delivery systems is critical for GF‐based regeneration. Many different delivery systems have been developed to achieve tunable delivery kinetics for single or multiple GFs. The identification of ideal biomaterials with tunable properties for spatiotemporal delivery of GFs is still challenging. This review characterizes the types, properties, and functions of GFs, the materials science of widely used biomaterials, and various GF loading strategies to comprehensively summarize the current delivery systems for tunable spatiotemporal delivery of GFs aimed for tissue regeneration applications. This review concludes by discussing fundamental design principles for GF delivery vehicles based on the interactive physicochemical properties of the proteins and biomaterials.
Growth factor delivery is emerging as a potential alternative for healing severely injured complex tissues. Engineering delivery system with increased payloads and tunable release kinetics remains challenging in the realm of translational research. This review discusses the complexities behind growth factors and biomaterials to advance the development of modern delivery systems to meet the current challenges for effective tissue repair.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30398700</pmid><doi>10.1002/adhm.201801000</doi><tpages>24</tpages><orcidid>https://orcid.org/0000-0003-0044-9740</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biocompatible Materials - chemistry Biomaterials Biomedical materials Biomimetics Cell migration Cell proliferation delivery systems Design Design engineering Drug Delivery Systems Growth factors Humans Intercellular Signaling Peptides and Proteins - administration & dosage Intercellular Signaling Peptides and Proteins - therapeutic use Kinetics loading strategies Materials Science Pharmacology Physicochemical properties Properties (attributes) Proteins Regeneration Regeneration (physiology) Regenerative Medicine release kinetics Stem cells Therapeutic applications Tissue Engineering tissue engineering and regenerative medicine |
| title | Materials Science and Design Principles of Growth Factor Delivery Systems in Tissue Engineering and Regenerative Medicine |
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