Developability Assessment of Engineered Monoclonal Antibody Variants with a Complex Self-Association Behavior Using Complementary Analytical and in Silico Tools

Monoclonal antibodies (mAbs) are complex molecular structures. They are often prone to development challenges particularly at high concentrations due to undesired solution properties such as reversible self-association, high viscosity, and liquid–liquid phase separation. In addition to formulation o...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular pharmaceutics 2018-12, Vol.15 (12), p.5697-5710
Hauptverfasser:	Shan, Lu, Mody, Neil, Sormani, Pietro, Rosenthal, Kim L., Damschroder, Melissa M., Esfandiary, Reza
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!