NMR fragment-based screening for development of the CD44-binding small molecules

[Display omitted] •Eight new small molecules with affinity for CD44 were found by fragment-based screening.•Binding constants for new hit compounds are between 0.66 and 2.65 mM.•A detailed analysis of the binding suggests the existence of two distinct binding modes.•In one of these modes the binding...

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Veröffentlicht in:	Bioorganic chemistry 2019-02, Vol.82, p.284-289
Hauptverfasser:	Pustuła, Marcin, Czub, Mirosława, Łabuzek, Beata, Surmiak, Ewa, Tomala, Marcin, Twarda-Clapa, Aleksandra, Guzik, Katarzyna, Popowicz, Grzegorz M., Holak, Tad A.
Format:	Artikel
Sprache:	eng
Schlagworte:	CD44 Fragment-based screening Hyaluronic acid Small-molecular inhibitors
Online-Zugang:	Volltext
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