Dual-Targeting Nanoparticles: Codelivery of Curcumin and 5-Fluorouracil for Synergistic Treatment of Hepatocarcinoma

Chemotherapy has been the standard for cancer therapy, but the nonspecific cytotoxicity of chemotherapeutic agents and drug resistance of tumor cells has limited its efficacy. However, multidrug combination therapy and targeting therapy have resulted in enhanced anticancer effects and have become in...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2019-03, Vol.108 (3), p.1284-1295
Hauptverfasser:	Ni, Wenfeng, Li, Zhengye, Liu, Zengquan, Ji, Yuting, Wu, Lijia, Sun, Sizhe, Jian, Xiqi, Gao, Xiujun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Biotin - chemistry cancer chemotherapy Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Curcumin - administration & dosage Curcumin - pharmacokinetics Disaccharides - chemistry Drug Carriers - chemistry Drug Liberation Drug Synergism Fluorouracil - administration & dosage Fluorouracil - pharmacokinetics Hep G2 Cells Humans Liver Neoplasms - drug therapy Liver Neoplasms - pathology Mice nanoparticles Nanoparticles - chemistry polyethylene glycol Polyethylene Glycols - chemistry Polyglactin 910 - chemistry polyglycolic acid targeted drug delivery Tissue Distribution Xenograft Model Antitumor Assays
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