Granzyme K Expressed by Classically Activated Macrophages Contributes to Inflammation and Impaired Remodeling

Granzyme K (GzmK), traditionally described as a pro-apoptotic, granule-secreted serine protease, has been proposed to promote inflammation. Found at low levels in the plasma of healthy individuals, GzmK is markedly elevated in response to sepsis and infection. In this study we investigated the role...

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Veröffentlicht in:	Journal of investigative dermatology 2019-04, Vol.139 (4), p.930-939
Hauptverfasser:	Turner, Christopher T., Zeglinski, Matthew R., Richardson, Katlyn C., Zhao, Hongyan, Shen, Yue, Papp, Anthony, Bird, Phillip I., Granville, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Burns - genetics Burns - metabolism Burns - pathology Cytokines - biosynthesis Cytokines - genetics Disease Models, Animal Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Regulation Granzymes - biosynthesis Granzymes - genetics Humans Immunohistochemistry Inflammation - genetics Inflammation - metabolism Inflammation - pathology Keratinocytes - metabolism Keratinocytes - pathology Macrophages - metabolism Macrophages - pathology Mice Re-Epithelialization - physiology RNA - genetics
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