A desymmetrization-based approach to morphinans: application in the total synthesis of oxycodone

Here we report a total synthesis of the pharmacologically significant morphinan alkaloid, oxycodone. The centerpiece of the developed strategy features the first application of the Rovis desymmetrization of peroxyquinol in target-oriented total synthesis to access an optically active phenanthrene fr...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2018-11, Vol.54 (92), p.1318-1321
Hauptverfasser:	Park, Kun Ho (Kenny), Chen, David Y.-K
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclization - radiation effects Light Molecular structure Optical activity Oxidation-Reduction Oxycodone - chemical synthesis Pharmacology Phenanthrene Piperidine Stereoisomerism Synthesis
Online-Zugang:	Volltext
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