Pan-senescence transcriptome analysis identified RRAD as a marker and negative regulator of cellular senescence

Cellular senescence, an irreversible proliferative arrest, functions in tissue remodeling during development and is implicated in multiple aging-associated diseases. While senescent cells often manifest an array of senescence-associated phenotypes, such as cell cycle arrest, altered heterochromatin...

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Veröffentlicht in:	Free radical biology & medicine 2019-01, Vol.130, p.267-277
Hauptverfasser:	Wei, Zhao, Guo, Haiyang, Qin, Junchao, Lu, Shihua, Liu, Qiao, Zhang, Xiyu, Zou, Yongxin, Gong, Yaoqin, Shao, Changshun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Biomarkers - metabolism Cellular Senescence - genetics Fibroblasts - drug effects Humans Hydrogen Peroxide - metabolism NF-kappa B - genetics Oxidative Stress - drug effects Oxidative Stress - genetics Oxidative Stress - radiation effects Protein Binding Radiation, Ionizing ras Proteins - genetics Reactive Oxygen Species - metabolism Skin - cytology Skin - drug effects Skin - metabolism Transcription Factor RelA - genetics Transcriptome - genetics Tumor Suppressor Protein p53 - genetics
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