Downregulation of Dopamine D1-like Receptor Pathways of GABAergic Interneurons in the Anterior Cingulate Cortex of Spontaneously Hypertensive Rats

•Dopamine enhances GABAergic transmission onto layer V pyramidal cells in the anterior cingulate cortex.•The modulatory action is involved with activation of D1-like receptor at GABAergic interneurons.•GABAergic synapses in the anterior cingulate cortex of ADHD model rat exhibit diminution of the mo...

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Veröffentlicht in:	Neuroscience 2018-12, Vol.394, p.267-285
Hauptverfasser:	Satoh, Hiromasa, Suzuki, Hidenori, Saitow, Fumihito
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals anterior cingulate cortex (ACC) Attention Deficit Disorder with Hyperactivity - physiopathology attention-deficit/hyperactivity disorder (ADHD) Dopamine - physiology Dopamine Agonists - administration & dosage Dopamine Antagonists - administration & dosage dopamine D1-like receptors Down-Regulation fast-spiking interneurons GABAergic Neurons - physiology gamma-amino butyric acid (GABA) Gyrus Cinguli - physiology Inhibitory Postsynaptic Potentials Interneurons - physiology Male Pyramidal Cells - cytology Pyramidal Cells - physiology Rats, Inbred SHR Rats, Inbred WKY Receptors, Dopamine - physiology Receptors, Dopamine D1 - agonists Receptors, Dopamine D1 - antagonists & inhibitors Receptors, Dopamine D1 - physiology Receptors, Dopamine D2 - physiology spontaneously hypertensive rat (SHR)
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