Adipose tissue-derived mesenchymal stem cells cultured at high density express IFN-β and TRAIL and suppress the growth of H460 human lung cancer cells

Although mesenchymal stem cells (MSCs) have been reported to inhibit tumor growth, the mechanism controlling this tumor suppression function is unclear. Here, we report that high-density (40,000 cells/cm2) cultured adipose tissue-derived MSCs (40K-ASCs) expressed interferon (IFN)-β and tumor necrosi...

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Veröffentlicht in:	Cancer letters 2019-01, Vol.440-441, p.202-210
Hauptverfasser:	Jung, Pil Young, Ryu, Hoon, Rhee, Ki-Jong, Hwang, Soonjae, Lee, Chang Gun, Gwon, Sun-Yeong, Kim, Jiye, Kim, Juwon, Yoo, Byung-Su, Baik, Soon Koo, Bae, Keum Seok, Eom, Young Woo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose tissue-derived mesenchymal stem cells Animal models Apoptosis Body fat Cell culture Cell cycle Cell death Density Fibroblasts Gene expression Glucose IFN-β Immunoglobulins Interferon Lung cancer Mesenchymal stem cells Mesenchyme Morphology Necrotic cell death Penicillin Protein expression Proteins R&D Research & development Stem cell transplantation Stem cells TRAIL TRAIL protein Transplantation Tumor suppression Tumors Weight reduction β-Interferon
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