Is it Possible to Implant HeartMate 3 Less Invasively? New Pump, New Approach
HeartMate 3 (HM3) left ventricular assist device (LVAD) is a compact, intrapericardial, centrifugal flow pump with a fully magnetically levitated rotor and a wide range of operation (2–10 L/min) to accommodate a broad range of clinical needs. We analyzed our experience with Heartware VAD (HVAD) and...
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Veröffentlicht in: | Artificial organs 2018-12, Vol.42 (12), p.1132-1138 |
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creator | Kocabeyoglu, Sinan Sabit Kervan, Umit Sert, Dogan Emre Unal, Ertekin Utku Demirkan, Burcu Guray, Yesim Aygun, Emre Beyazal, Osman Fehmi Karahan, Mehmet Pac, Mustafa |
description | HeartMate 3 (HM3) left ventricular assist device (LVAD) is a compact, intrapericardial, centrifugal flow pump with a fully magnetically levitated rotor and a wide range of operation (2–10 L/min) to accommodate a broad range of clinical needs. We analyzed our experience with Heartware VAD (HVAD) and HM3 implantation through minimally invasive left thoracotomy (MILT) and upper minimal J sternotomy. Between March 2015 and October 2016, 31 patients who underwent LVAD implantation through MILT were included in this study. Twenty‐three patients had HVAD (Group A) implantation, whereas 8 patients had HM3 (Group B). To compare outcomes of these pumps, measures were; mortality, cardiopulmonary bypass (CPB) time, duration of mechanical ventilatory support, blood loss and transfusion, intensive care unit (ICU) stay, right ventricular failure (RVF) and requirement of support with temporary devices, stroke, pump thrombosis, gastrointestinal bleeding and driveline infection rates. Interagency Registry for Mechanically Assisted Circulatory Support profiles, Pennsylvania and Michigan Risk Scores, right ventricular stroke work index and central venous pressure/pulmonary capillary wedge pressure ratio did not differ between these two groups. There was no difference in the length of ICU stay (P = 0.056), post‐operative blood product administration (P = 0.701), total time on mechanical ventilation (P = 0.386), RVF (P = 1) or duration of CPB (P = 0.836). In‐hospital cerebrovascular event rate was 13% in Group A and 0% in Group B, respectively. The HM3 assist system can be successfully implanted with minimally invasive techniques. This technique has proved to be safe and reproducible, with good clinical outcomes. Further, large collaborative studies are needed to identify the advantages of this approach. |
doi_str_mv | 10.1111/aor.13289 |
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New Pump, New Approach</title><source>Wiley Journals</source><creator>Kocabeyoglu, Sinan Sabit ; Kervan, Umit ; Sert, Dogan Emre ; Unal, Ertekin Utku ; Demirkan, Burcu ; Guray, Yesim ; Aygun, Emre ; Beyazal, Osman Fehmi ; Karahan, Mehmet ; Pac, Mustafa</creator><creatorcontrib>Kocabeyoglu, Sinan Sabit ; Kervan, Umit ; Sert, Dogan Emre ; Unal, Ertekin Utku ; Demirkan, Burcu ; Guray, Yesim ; Aygun, Emre ; Beyazal, Osman Fehmi ; Karahan, Mehmet ; Pac, Mustafa</creatorcontrib><description>HeartMate 3 (HM3) left ventricular assist device (LVAD) is a compact, intrapericardial, centrifugal flow pump with a fully magnetically levitated rotor and a wide range of operation (2–10 L/min) to accommodate a broad range of clinical needs. We analyzed our experience with Heartware VAD (HVAD) and HM3 implantation through minimally invasive left thoracotomy (MILT) and upper minimal J sternotomy. Between March 2015 and October 2016, 31 patients who underwent LVAD implantation through MILT were included in this study. Twenty‐three patients had HVAD (Group A) implantation, whereas 8 patients had HM3 (Group B). To compare outcomes of these pumps, measures were; mortality, cardiopulmonary bypass (CPB) time, duration of mechanical ventilatory support, blood loss and transfusion, intensive care unit (ICU) stay, right ventricular failure (RVF) and requirement of support with temporary devices, stroke, pump thrombosis, gastrointestinal bleeding and driveline infection rates. Interagency Registry for Mechanically Assisted Circulatory Support profiles, Pennsylvania and Michigan Risk Scores, right ventricular stroke work index and central venous pressure/pulmonary capillary wedge pressure ratio did not differ between these two groups. There was no difference in the length of ICU stay (P = 0.056), post‐operative blood product administration (P = 0.701), total time on mechanical ventilation (P = 0.386), RVF (P = 1) or duration of CPB (P = 0.836). In‐hospital cerebrovascular event rate was 13% in Group A and 0% in Group B, respectively. The HM3 assist system can be successfully implanted with minimally invasive techniques. This technique has proved to be safe and reproducible, with good clinical outcomes. Further, large collaborative studies are needed to identify the advantages of this approach.</description><identifier>ISSN: 0160-564X</identifier><identifier>EISSN: 1525-1594</identifier><identifier>DOI: 10.1111/aor.13289</identifier><identifier>PMID: 30393885</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Bleeding ; Blood transfusion ; Capillary pressure ; Centrifugal pumps ; Health risks ; Heart ; Heart surgery ; Implantation ; Left ventricular assist device ; Mechanical circulatory support ; Mechanical ventilation ; Minimally invasive ; Ostomy ; Patients ; Pressure ; Pressure ratio ; Right ventricular failure ; Thoracotomy ; Thromboembolism ; Thrombosis ; Transfusion ; Ventilation ; Ventricle</subject><ispartof>Artificial organs, 2018-12, Vol.42 (12), p.1132-1138</ispartof><rights>2018 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.</rights><rights>Copyright © 2018 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-2aaf4d81e0d504dc072ebc57996de2f0a2cd1f519c6f32674de0982c03c7b1c53</citedby><cites>FETCH-LOGICAL-c3539-2aaf4d81e0d504dc072ebc57996de2f0a2cd1f519c6f32674de0982c03c7b1c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faor.13289$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faor.13289$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30393885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kocabeyoglu, Sinan Sabit</creatorcontrib><creatorcontrib>Kervan, Umit</creatorcontrib><creatorcontrib>Sert, Dogan Emre</creatorcontrib><creatorcontrib>Unal, Ertekin Utku</creatorcontrib><creatorcontrib>Demirkan, Burcu</creatorcontrib><creatorcontrib>Guray, Yesim</creatorcontrib><creatorcontrib>Aygun, Emre</creatorcontrib><creatorcontrib>Beyazal, Osman Fehmi</creatorcontrib><creatorcontrib>Karahan, Mehmet</creatorcontrib><creatorcontrib>Pac, Mustafa</creatorcontrib><title>Is it Possible to Implant HeartMate 3 Less Invasively? New Pump, New Approach</title><title>Artificial organs</title><addtitle>Artif Organs</addtitle><description>HeartMate 3 (HM3) left ventricular assist device (LVAD) is a compact, intrapericardial, centrifugal flow pump with a fully magnetically levitated rotor and a wide range of operation (2–10 L/min) to accommodate a broad range of clinical needs. We analyzed our experience with Heartware VAD (HVAD) and HM3 implantation through minimally invasive left thoracotomy (MILT) and upper minimal J sternotomy. Between March 2015 and October 2016, 31 patients who underwent LVAD implantation through MILT were included in this study. Twenty‐three patients had HVAD (Group A) implantation, whereas 8 patients had HM3 (Group B). To compare outcomes of these pumps, measures were; mortality, cardiopulmonary bypass (CPB) time, duration of mechanical ventilatory support, blood loss and transfusion, intensive care unit (ICU) stay, right ventricular failure (RVF) and requirement of support with temporary devices, stroke, pump thrombosis, gastrointestinal bleeding and driveline infection rates. Interagency Registry for Mechanically Assisted Circulatory Support profiles, Pennsylvania and Michigan Risk Scores, right ventricular stroke work index and central venous pressure/pulmonary capillary wedge pressure ratio did not differ between these two groups. There was no difference in the length of ICU stay (P = 0.056), post‐operative blood product administration (P = 0.701), total time on mechanical ventilation (P = 0.386), RVF (P = 1) or duration of CPB (P = 0.836). In‐hospital cerebrovascular event rate was 13% in Group A and 0% in Group B, respectively. The HM3 assist system can be successfully implanted with minimally invasive techniques. This technique has proved to be safe and reproducible, with good clinical outcomes. Further, large collaborative studies are needed to identify the advantages of this approach.</description><subject>Bleeding</subject><subject>Blood transfusion</subject><subject>Capillary pressure</subject><subject>Centrifugal pumps</subject><subject>Health risks</subject><subject>Heart</subject><subject>Heart surgery</subject><subject>Implantation</subject><subject>Left ventricular assist device</subject><subject>Mechanical circulatory support</subject><subject>Mechanical ventilation</subject><subject>Minimally invasive</subject><subject>Ostomy</subject><subject>Patients</subject><subject>Pressure</subject><subject>Pressure ratio</subject><subject>Right ventricular failure</subject><subject>Thoracotomy</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Transfusion</subject><subject>Ventilation</subject><subject>Ventricle</subject><issn>0160-564X</issn><issn>1525-1594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kMFKw0AQhhdRbK0efAFZ8KJg6uxuNps9SRG1hWpFFLyF7WaCkaSJ2cTSt3fbqgfBucwcPv75-Qg5ZjBkfi5N1QyZ4LHeIX0muQyY1OEu6QOLIJBR-NojB869A4AKIdonPQFCiziWfXI_cTRv6WPlXD4vkLYVnZR1YRYtHaNp2nvTIhV0is7RyeLTuPwTi9UVfcAlfezK-mJzjeq6qYx9OyR7mSkcHn3vAXm5vXm-HgfT2d3kejQNrJBCB9yYLExjhpBKCFMLiuPcSqV1lCLPwHCbskwybaNM8EiFKYKOuQVh1ZxZKQbkbJvr33506NqkzJ3FwvfGqnMJZwJAqlgIj57-Qd-rrln4dp6SWiiu1Jo631K28SYazJK6yUvTrBIGydpx4h0nG8eePflO7OYlpr_kj1QPXG6BZV7g6v-kZDR72kZ-AcRCgzY</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Kocabeyoglu, Sinan Sabit</creator><creator>Kervan, Umit</creator><creator>Sert, Dogan Emre</creator><creator>Unal, Ertekin Utku</creator><creator>Demirkan, Burcu</creator><creator>Guray, Yesim</creator><creator>Aygun, Emre</creator><creator>Beyazal, Osman Fehmi</creator><creator>Karahan, Mehmet</creator><creator>Pac, Mustafa</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201812</creationdate><title>Is it Possible to Implant HeartMate 3 Less Invasively? New Pump, New Approach</title><author>Kocabeyoglu, Sinan Sabit ; Kervan, Umit ; Sert, Dogan Emre ; Unal, Ertekin Utku ; Demirkan, Burcu ; Guray, Yesim ; Aygun, Emre ; Beyazal, Osman Fehmi ; Karahan, Mehmet ; Pac, Mustafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-2aaf4d81e0d504dc072ebc57996de2f0a2cd1f519c6f32674de0982c03c7b1c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Bleeding</topic><topic>Blood transfusion</topic><topic>Capillary pressure</topic><topic>Centrifugal pumps</topic><topic>Health risks</topic><topic>Heart</topic><topic>Heart surgery</topic><topic>Implantation</topic><topic>Left ventricular assist device</topic><topic>Mechanical circulatory support</topic><topic>Mechanical ventilation</topic><topic>Minimally invasive</topic><topic>Ostomy</topic><topic>Patients</topic><topic>Pressure</topic><topic>Pressure ratio</topic><topic>Right ventricular failure</topic><topic>Thoracotomy</topic><topic>Thromboembolism</topic><topic>Thrombosis</topic><topic>Transfusion</topic><topic>Ventilation</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kocabeyoglu, Sinan Sabit</creatorcontrib><creatorcontrib>Kervan, Umit</creatorcontrib><creatorcontrib>Sert, Dogan Emre</creatorcontrib><creatorcontrib>Unal, Ertekin Utku</creatorcontrib><creatorcontrib>Demirkan, Burcu</creatorcontrib><creatorcontrib>Guray, Yesim</creatorcontrib><creatorcontrib>Aygun, Emre</creatorcontrib><creatorcontrib>Beyazal, Osman Fehmi</creatorcontrib><creatorcontrib>Karahan, Mehmet</creatorcontrib><creatorcontrib>Pac, Mustafa</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kocabeyoglu, Sinan Sabit</au><au>Kervan, Umit</au><au>Sert, Dogan Emre</au><au>Unal, Ertekin Utku</au><au>Demirkan, Burcu</au><au>Guray, Yesim</au><au>Aygun, Emre</au><au>Beyazal, Osman Fehmi</au><au>Karahan, Mehmet</au><au>Pac, Mustafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is it Possible to Implant HeartMate 3 Less Invasively? New Pump, New Approach</atitle><jtitle>Artificial organs</jtitle><addtitle>Artif Organs</addtitle><date>2018-12</date><risdate>2018</risdate><volume>42</volume><issue>12</issue><spage>1132</spage><epage>1138</epage><pages>1132-1138</pages><issn>0160-564X</issn><eissn>1525-1594</eissn><abstract>HeartMate 3 (HM3) left ventricular assist device (LVAD) is a compact, intrapericardial, centrifugal flow pump with a fully magnetically levitated rotor and a wide range of operation (2–10 L/min) to accommodate a broad range of clinical needs. We analyzed our experience with Heartware VAD (HVAD) and HM3 implantation through minimally invasive left thoracotomy (MILT) and upper minimal J sternotomy. Between March 2015 and October 2016, 31 patients who underwent LVAD implantation through MILT were included in this study. Twenty‐three patients had HVAD (Group A) implantation, whereas 8 patients had HM3 (Group B). To compare outcomes of these pumps, measures were; mortality, cardiopulmonary bypass (CPB) time, duration of mechanical ventilatory support, blood loss and transfusion, intensive care unit (ICU) stay, right ventricular failure (RVF) and requirement of support with temporary devices, stroke, pump thrombosis, gastrointestinal bleeding and driveline infection rates. Interagency Registry for Mechanically Assisted Circulatory Support profiles, Pennsylvania and Michigan Risk Scores, right ventricular stroke work index and central venous pressure/pulmonary capillary wedge pressure ratio did not differ between these two groups. There was no difference in the length of ICU stay (P = 0.056), post‐operative blood product administration (P = 0.701), total time on mechanical ventilation (P = 0.386), RVF (P = 1) or duration of CPB (P = 0.836). In‐hospital cerebrovascular event rate was 13% in Group A and 0% in Group B, respectively. The HM3 assist system can be successfully implanted with minimally invasive techniques. This technique has proved to be safe and reproducible, with good clinical outcomes. Further, large collaborative studies are needed to identify the advantages of this approach.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30393885</pmid><doi>10.1111/aor.13289</doi><tpages>0</tpages></addata></record> |
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subjects | Bleeding Blood transfusion Capillary pressure Centrifugal pumps Health risks Heart Heart surgery Implantation Left ventricular assist device Mechanical circulatory support Mechanical ventilation Minimally invasive Ostomy Patients Pressure Pressure ratio Right ventricular failure Thoracotomy Thromboembolism Thrombosis Transfusion Ventilation Ventricle |
title | Is it Possible to Implant HeartMate 3 Less Invasively? New Pump, New Approach |
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